Search Results - "Schwartz, Jae"

A Dual Pressure Linear Ion Trap Orbitrap Instrument with Very High Sequencing Speed by Olsen, Jesper V., Schwartz, Jae C., Griep-Raming, Jens, Nielsen, Michael L., Damoc, Eugen, Denisov, Eduard, Lange, Oliver, Remes, Philip, Taylor, Dennis, Splendore, Maurizio, Wouters, Eloy R., Senko, Michael, Makarov, Alexander, Mann, Matthias, Horning, Stevan

“…Since its introduction a few years ago, the linear ion trap Orbitrap (LTQ Orbitrap) instrument has become a powerful tool in proteomics research. For high…”
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Ultra High Resolution Linear Ion Trap Orbitrap Mass Spectrometer (Orbitrap Elite) Facilitates Top Down LC MS/MS and Versatile Peptide Fragmentation Modes by Michalski, Annette, Damoc, Eugen, Lange, Oliver, Denisov, Eduard, Nolting, Dirk, Müller, Mathias, Viner, Rosa, Schwartz, Jae, Remes, Philip, Belford, Michael, Dunyach, Jean-Jacques, Cox, Juergen, Horning, Stevan, Mann, Matthias, Makarov, Alexander

“…Although only a few years old, the combination of a linear ion trap with an Orbitrap analyzer has become one of the standard mass spectrometers to characterize…”
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Enhanced Sequence Coverage of Large Proteins by Combining Ultraviolet Photodissociation with Proton Transfer Reactions by Sanders, James D, Mullen, Christopher, Watts, Eleanor, Holden, Dustin D, Syka, John E. P, Schwartz, Jae C, Brodbelt, Jennifer S

“…Ultraviolet photodissociation (UVPD) produces rich and informative fragmentation of intact protein ions, but in the case of high mass proteins (>30 kDa) the…”
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Supplemental Activation Method for High-Efficiency Electron-Transfer Dissociation of Doubly Protonated Peptide Precursors by Swaney, Danielle L, McAlister, Graeme C, Wirtala, Matthew, Schwartz, Jae C, Syka, John E. P, Coon, Joshua J

“…Electron-transfer dissociation (ETD) delivers the unique attributes of electron capture dissociation to mass spectrometers that utilize radio frequency…”
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Nested-channel for on-demand alternation between electrospray ionization regimes by Li, Mengtian, Li, Huishan, Allen, Nicholas R, Wang, Taoqing, Li, Linfan, Schwartz, Jae, Li, Anyin

“…On-demand electrospray ionization from different liquid channels in the same emitter was realized using filamented capillary and gas phase charge supply. The…”
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Dual-Pressure Linear Ion Trap Mass Spectrometer Improving the Analysis of Complex Protein Mixtures by Pekar Second, Tonya, Blethrow, Justin D, Schwartz, Jae C, Merrihew, Gennifer E, MacCoss, Michael J, Swaney, Danielle L, Russell, Jason D, Coon, Joshua J, Zabrouskov, Vlad

“…The considerable progress in high-throughput proteomics analysis via liquid chromatography−electrospray ionization-tandem mass spectrometry over the past…”
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Implementation of Fragment Ion Protection (FIP) during Ultraviolet Photodissociation (UVPD) Mass Spectrometry by Holden, Dustin D, Sanders, James D, Weisbrod, Chad R, Mullen, Christopher, Schwartz, Jae C, Brodbelt, Jennifer S

“…Ultraviolet photodissociation (UVPD) is a nonselective activation method in which both precursor and fragment ions may absorb photons and dissociate…”
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A Neutral Loss Activation Method for Improved Phosphopeptide Sequence Analysis by Quadrupole Ion Trap Mass Spectrometry by Schroeder, Melanie J, Shabanowitz, Jeffrey, Schwartz, Jae C, Hunt, Donald F, Coon, Joshua J

“…Recent advances in phosphopeptide enrichment prior to mass spectrometric analysis show genuine promise for characterization of phosphoproteomes. Tandem mass…”
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Unraveling Molecular Complexity of Phosphorylated Human Cardiac Troponin I by Top Down Electron Capture Dissociation/Electron Transfer Dissociation Mass Spectrometry by Zabrouskov, Vlad, Ge, Ying, Schwartz, Jae, Walker, Jeffery W.

“…Cardiac troponin I (cTnI), the inhibitory subunit of the thin filament troponin-tropomyosin regulatory complex, is required for heart muscle relaxation during…”
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Infrared Photoactivation Reduces Peptide Folding and Hydrogen-Atom Migration following ETD Tandem Mass Spectrometry by Ledvina, Aaron R, McAlister, Graeme C, Gardner, Myles W, Smith, Suncerae I, Madsen, James A, Schwartz, Jae C, Stafford, George C. Jr, Syka, John E.P, Brodbelt, Jennifer S, Coon, Joshua J

“…Peptides see the light: The photoactivation of peptide precursor cations during electron transfer dissociation (ETD) led to the generation of isotopic cluster…”
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Ultraviolet Photodissociation Induced by Light-Emitting Diodes in a Planar Ion Trap by Holden, Dustin D., Makarov, Alexander, Schwartz, Jae C., Sanders, James D., Zhuk, Eugene, Brodbelt, Jennifer S.

“…The first application of light‐emitting diodes (LEDs) for ultraviolet photodissociation (UVPD) mass spectrometry is reported. LEDs provide a compact, low cost…”
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Novel Linear Quadrupole Ion Trap/FT Mass Spectrometer:  Performance Characterization and Use in the Comparative Analysis of Histone H3 Post-translational Modifications by Syka, John E. P, Marto, Jarrod A, Bai, Dina L, Horning, Stevan, Senko, Michael W, Schwartz, Jae C, Ueberheide, Beatrix, Garcia, Benjamin, Busby, Scott, Muratore, Tara, Shabanowitz, Jeffrey, Hunt, Donald F

“…We describe the design and performance of a prototype high performance hybrid mass spectrometer. This instrument consists of a linear quadrupole ion trap (QLT)…”
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Activated-Ion Electron Transfer Dissociation Improves the Ability of Electron Transfer Dissociation to Identify Peptides in a Complex Mixture by Ledvina, Aaron R, Beauchene, Nicole A, McAlister, Graeme C, Syka, John E. P, Schwartz, Jae C, Griep-Raming, Jens, Westphall, Michael S, Coon, Joshua J

“…Using a modified electron transfer dissociation (ETD)-enabled quadrupole linear ion trap (QLT) mass spectrometer, we demonstrate the utility of IR activation…”
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A two-dimensional quadrupole ion trap mass spectrometer by Schwartz, Jae C, Senko, Michael W, Syka, John E.P

“…The use of a linear or two-dimensional (2-D) quadrupole ion trap as a high performance mass spectrometer is demonstrated. Mass analysis is performed by…”
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MS(M), an efficient workflow for metabolite identification using hybrid linear ion trap Orbitrap mass spectrometer by Cho, Robert, Huang, Yingying, Schwartz, Jae C, Chen, Yan, Carlson, Timothy J, Ma, Ji

“…Identification of drug metabolites can often yield important information regarding clearance mechanism, pharmacologic activity, or toxicity for drug candidate…”
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A Differentially Pumped Dual Linear Quadrupole Ion Trap (DLQIT) Mass Spectrometer: A Mass Spectrometer Capable of MSn Experiments Free From Interfering Reactions by Owen, Benjamin C, Jarrell, Tiffany M, Schwartz, Jae C, Oglesbee, Rob, Carlsen, Mark, Archibold, Enada F, Kenttämaa, Hilkka I

“…A novel differentially pumped dual linear quadrupole ion trap (DLQIT) mass spectrometer was designed and built to facilitate tandem MS experiments free from…”
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Activated Ion ETD Performed in a Modified Collision Cell on a Hybrid QLT-Oribtrap Mass Spectrometer by Ledvina, Aaron R., Rose, Christopher M., McAlister, Graeme C., Syka, John E. P., Westphall, Michael S., Griep-Raming, Jens, Schwartz, Jae C., Coon, Joshua J.

“…We describe the implementation and characterization of activated ion electron transfer dissociation (AI-ETD) on a hybrid QLT-Orbitrap mass spectrometer. AI-ETD…”
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A differentially pumped dual linear quadrupole ion trap (DLQIT) mass spectrometer: a mass spectrometer capable of MS(n) experiments free from interfering reactions by Owen, Benjamin C, Jarrell, Tiffany M, Schwartz, Jae C, Oglesbee, Rob, Carlsen, Mark, Archibold, Enada F, Kenttämaa, Hilkka I

“…A novel differentially pumped dual linear quadrupole ion trap (DLQIT) mass spectrometer was designed and built to facilitate tandem MS experiments free from…”
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Multipurpose Dissociation Cell for Enhanced ETD of Intact Protein Species by Rose, Christopher M., Russell, Jason D., Ledvina, Aaron R., McAlister, Graeme C., Westphall, Michael S., Griep-Raming, Jens, Schwartz, Jae C., Coon, Joshua J., Syka, John E. P.

“…We describe and characterize an improved implementation of ETD on a modified hybrid linear ion trap-Orbitrap instrument. Instead of performing ETD in the…”
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MSM, an Efficient Workflow for Metabolite Identification Using Hybrid Linear Ion Trap Orbitrap Mass Spectrometer by Cho, Robert, Huang, Yingying, Schwartz, Jae C., Chen, Yan, Carlson, Timothy J., Ma, Ji

“…Identification of drug metabolites can often yield important information regarding clearance mechanism, pharmacologic activity, or toxicity for drug candidate…”
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