Search Results - "Schwartz, J I"

Comparison of rofecoxib, celecoxib, and naproxen on renal function in elderly subjects receiving a normal-salt diet by Schwartz, J. I., Vandormael, K., Malice, M. P., Kalyani, R. N., Lasseter, K. C., Holmes, G. B., Gertz, B. J., Gottesdiener, K. M., Laurenzi, M., Redfern, K.‐J., Brune, K.

“…Background This study compared directly the renal effects of two selective cyclooxygenase (COX)‐2 inhibitors (rofecoxib and celecoxib) with naproxen (dual…”
Get full text

Effect of cyclooxygenase-2 inhibition on renal function in elderly persons receiving a low-salt diet : A randomized, controlled trial by SWAN, S. K, RUDY, D. W, GUMBS, C. P, EBEL, D. L, HUI QUAN, LARSON, P. J, SCHWARTZ, J. I, MUSLINER, T. A, GERTZ, B. J, BRATER, D. C, YAO, S.-L, LASSETER, K. C, RYAN, C. F, BUECHEL, K. L, LAMBRECHT, L. J, PINTO, M. B, DILZER, S. C, OBRDA, O, SUNDBLAD, K. J

“…Most nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both cyclooxygenase-1 (COX-1), whose inhibition is associated with gastrointestinal ulceration, and…”
Get full text

Comparative Inhibitory Activity of Rofecoxib, Meloxicam, Diclofenac, Ibuprofen, and Naproxen on COX-2 versus COX-1 in Healthy Volunteers by van Hecken, Anne, Schwartz, Jules I., Depré, Marleen, de Lepeleire, Inge, Dallob, Aimee, Tanaka, Wesley, Wynants, Kathleen, Buntinx, Agnes, Arnout, Jef, Wong, Peggy H., Ebel, David L., Gertz, Barry J., de Schepper, Paul J.

“…Steady‐state inhibitory activity of rofecoxib (Vioxx™) on COX‐2 versus COX‐1 was compared with that of commonly used nonsteroidal anti‐inflammatory drugs…”
Get full text

Metabolic Profiles of Montelukast Sodium (Singulair), a Potent Cysteinyl Leukotriene1 Receptor Antagonist, in Human Plasma and Bile by BALANI, S. K, XU, X, FREEMAN, A, HOLLAND, S. D, SCHWARTZ, J. I, LASSETER, K. C, GERTZ, B. J, ISENBERG, J. I, ROGERS, J. D, LIN, J. H, BAILLIE, T. A, PRATHA, V, KOSS, M. A, AMIN, R. D, DUFRESNE, C, MILLER, R. R, ARISON, B. H, DOSS, G. A, CHIBA, M

“…Montelukast sodium [1-{[(1( R )-(3-(2-(7-chloro-2-quinolinyl)-( E )- ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio]methyl}cyclopropylacetic…”
Get full text

Cyclooxygenase-2 inhibition by rofecoxib reverses naturally occurring fever in humans by Schwartz, Jules I., Chan, Chi‐Chung, Mukhopadhyay, Saurabh, McBride, Kathleen J., Jones, Terry M., Adcock, Sherilyn, Moritz, Carl, Hedges, Jerris, Grasing, Kenneth, Dobratz, David, Cohen, Robert A., Davidson, Michael H., Bachmann, Kenneth A., Gertz, Barry J.

“…Cyclooxygenase (COX) exists as constitutive (COX‐1) and inducible (COX‐2) isoforms. Nonsteroidal anti‐inflammatory drugs (NSAIDs) such as ibuprofen and…”
Get full text

Comparative pharmacokinetics of lovastatin, simvastatin and pravastatin in humans by Pentikainen, P J, Saraheimo, M, Schwartz, J I, Amin, R D, Schwartz, M S, Brunner-Ferber, F, Rogers, J D

“…Twelve healthy male volunteers received single market-image 40-mg oral doses of lovastatin and simvastatin (both lactone prodrugs), or pravastatin (a…”
Get more information

Lack of Pharmacokinetic Interaction between Rofecoxib and Methotrexate in Rheumatoid Arthritis Patients by Schwartz, Jules I., Agrawal, Nancy G. B., Wong, Peggy H., Bachmann, Kenneth A., Porras, Arturo G., Miller, Jutta L., Ebel, David L., Sack, Marshall R., Holmes, Gregory B., Redfern, Jan S., Gertz, Barry J.

“…Rofecoxib is a highly selective and potent inhibitor of cyclooxgenase‐2 (COX‐2). Methotrexate is a disease‐modifying agent with a narrow therapeutic index…”
Get full text

Effect of MK-386, a novel inhibitor of type 1 5α- reductase, alone and in combination with finasteride, on serum dihydrotestosterone concentrations in men by SCHWARTZ, J. I, VAN HECKEN, A, EBEL, D. L, JUSTICE, S. J, GERTZ, B. J, DE SCHEPPER, P. J, DE LEPELEIRE, I, LASSETER, K. C, SHAMBLEN, E. C, WINCHELL, G. A, CONSTANZER, M. L, CHAVEZ, C. M, WANG, D. Z

“…Two isozymes (types 1 and 2) of 5 alpha-reductase (5 alpha R; EC 1.3.99.5), with differential tissue distribution, have been identified in humans. These…”
Get full text

Effect of Multiple Doses of Rifampin on the [14C N-methyl] Erythromycin Breath Test in Healthy Male Volunteers by Gharaibeh, Munir N., Gillen, Lisa P., Osborne, Barbara, Schwartz, Jules I., Waldman, Scott A.

“…The erythromycin breath test (EBT), which measures 14CO2 produced from [14C N‐methyl] erythromycin, is one of the most frequently employed measures to examine…”
Get full text

Novel oral medication delivery system for famotidine by Schwartz, J I, Yeh, K C, Berger, M L, Tomasko, L, Hoover, M E, Ebel, D L, Stauffer, L A, Han, R, Bjornsson, T D

“…A famotidine wafer that rapidly disperses on the tongue without water is a novel alternative to other histamine2 (H2)-antagonist dosage forms. Benefits…”
Get more information

Multiple-dose pharmacokinetics of intravenously administered cefoperazone and sulbactam when given in combination to infected, seriously ill, elderly patients by SCHWARTZ, J. I, JAUREGUI, L. E, BACHMANN, K. A, MARTIN, M. E, REITBERG, D. P

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Plasma concentrations and effect on testosterone metabolism after single doses of MK-0434, a steroid 5 alpha-reductase inhibitor, in healthy subjects by VAN HECKEN, A, DEPRE, M, SCHWARTZ, J. I, TJANDRAMAGA, T. B, WINCHELL, G. A, DE LEPELEIRE, I, NG, J, DE SCHEPPER, P. J

“…A four-period, two-panel, single-rising-dose study (0.1-100 mg) was conducted in healthy males to investigate the pharmacodynamics, tolerability and…”
Get full text

Evaluation of sustained/controlled-release dosage forms of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors in dogs and humans by HAIYUNG CHENG, SUTTON, S. C, LIU, L, EBEL, D. L, COULTER, A, ENGLE, K, MCCLELLAND, G. A, LUI, C. Y, RORK, G. S, PIPKIN, J. D, ZENTNER, G. M, ROGERS, J. D, SCHWARTZ, J. I, MITCHEL, Y. B, GRASING, K, SCHWARTZ, M. S, AMIN, R. D

“…Seven sustained/controlled-release dosage forms were designed for gastrointestinal delivery of lovastatin or simvastatin, two potent HMG-CoA reductase…”
Get full text

Inhibition of Exercise-Induced Bronchoconstriction by MK-571, a Potent Leukotriene D4–Receptor Antagonist by Manning, Patrick J, Watson, Richard M, Margolskee, Dorothy J, Williams, Vanessa C, Schwartz, Jules I, O'Byrne, Paul M

“…EXERCISE is a common stimulus of bronchoconstriction in subjects with asthma. 1 Exercise-induced bronchoconstriction may be caused by alterations in the…”
Get full text

The suitability of carbamazepine as a single-sample probe of human mixed function oxidase activity by Bachmann, K A, Schwartz, J I, Jauregui, L

“…1. Carbamazepine concentrations measured in plasma and plasma ultrafiltrates by fluorescence polarization immunoassay (f.p.i.a.) from 0 to 48 h post-dose were…”
Get more information

Pharmacodynamics of MK-0963, a new 5 alpha-reductase inhibitor: effects on serum androgen concentrations by Schwartz, J I, Laskin, O L, Meeter, C A, Patterson, P M, Schneider, S H, Lasseter, K C, Seibold, J R

“…The hormonal effects after a 10-day administration of a 4-azasteroid inhibitor of 5 alpha-reductase, MK-0963 (previously L-654,066), were evaluated in 35…”
Get more information

Predicting the ciprofloxacin‐theophylline interaction from single plasma theophylline measurements by Bachmann, KA, Schwartz, JI, Jauregui, L

“…The effect of ciprofloxacin treatment on theophylline clearance was evaluated with a theophylline multiple dose, multiple sample protocol and with a single…”
Get full text

A unique complication of a lumbar epidural catheter by Saberski, L R, Schwartz, J I, Greenhouse, B B, Kennedy, T M, Ullman, D A

Get full text

The bioavailability and nonlinear pharmacokinetics of MK-679 in humans by Cheng, H, Schwartz, J I, Lin, C, Amin, R D, Seibold, J R, Lasseter, K C, Ebel, D L, Tocco, D J, Rogers, J D

“…MK-679 (R(-)-3-((3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)(3- (dimethylamino)-3-oxo-propyl)thio)methyl)thio)propanoic acid) is a potent and specific…”
Get more information

P-434: Effect of rofecoxib, celecoxib, and naproxen on blood pressure (BP) in elderly volunteers by Schwartz, J. I., Malice, M. P., Kalyani, R., Lasseter, K., Holmes, G. B., Gertz, B. J., Gottesdiener, K., Laurenzi, M., Brune, K.

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) can affect sodium reabsorption by decreasing the synthesis of renal prostaglandins. This and other effects may…”
Get full text