Search Results - "Schwartz, Edward"

Antivascular Actions of Microtubule-Binding Drugs by SCHWARTZ, Edward L

“…Microtubule-binding drugs (MBD) are widely used in cancer chemotherapy and also have clinically relevant antiangiogenic and vascular-disrupting properties…”
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The Art, Science, and Engineering of Fuzzing: A Survey by Manes, Valentin J.M., Han, HyungSeok, Han, Choongwoo, Cha, Sang Kil, Egele, Manuel, Schwartz, Edward J., Woo, Maverick

“…Among the many software testing techniques available today, fuzzing has remained highly popular due to its conceptual simplicity, its low barrier to…”
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Targeting the untargetable: RB1-deficient tumours are vulnerable to Skp2 ubiquitin ligase inhibition by Gupta, Pranav, Zhao, Hongling, Hoang, Bang, Schwartz, Edward L.

“…Proteins that regulate the cell cycle are accumulated and degraded in a coordinated manner during the transition from one cell cycle phase to the next. The…”
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All You Ever Wanted to Know about Dynamic Taint Analysis and Forward Symbolic Execution (but Might Have Been Afraid to Ask) by Schwartz, Edward J, Avgerinos, Thanassis, Brumley, David

“…Dynamic taint analysis and forward symbolic execution are quickly becoming staple techniques in security analyses. Example applications of dynamic taint…”
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Lysosome Membrane Permeabilization and Disruption of the Molecular Target of Rapamycin (mTOR)-Lysosome Interaction Are Associated with the Inhibition of Lung Cancer Cell Proliferation by a Chloroquinoline Analog by Sironi, Juan, Aranda, Evelyn, Nordstrøm, Lars Ulrik, Schwartz, Edward L

“…Lysosomes degrade cellular proteins and organelles and regulate cell signaling by providing a surface for the formation of critical protein complexes, notably…”
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Targeted Inhibition of the E3 Ligase SCFSkp2/Cks1 Has Antitumor Activity in RB1 -Deficient Human and Mouse Small-Cell Lung Cancer by Zhao, Hongling, Iqbal, Niloy J., Sukrithan, Vineeth, Nicholas, Cari, Xue, Yingjiao, Yu, Cindy, Locker, Joseph, Zou, Juntao, Schwartz, Edward L., Zhu, Liang

“…Abstract The RB1 tumor suppressor gene is mutated in highly aggressive tumors including small-cell lung cancer (SCLC), where its loss, along with TP53, is…”
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DIRE: A Neural Approach to Decompiled Identifier Naming by Lacomis, Jeremy, Yin, Pengcheng, Schwartz, Edward, Allamanis, Miltiadis, Le Goues, Claire, Neubig, Graham, Vasilescu, Bogdan

“…The decompiler is one of the most common tools for examining binaries without corresponding source code. It transforms binaries into high-level code, reversing…”
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The autophagy inhibitor chloroquine overcomes the innate resistance of wild-type EGFR non-small-cell lung cancer cells to erlotinib by Zou, Yiyu, Ling, Yi-He, Sironi, Juan, Schwartz, Edward L, Perez-Soler, Roman, Piperdi, Bilal

“…The epidermal growth factor receptor (EGFR) inhibitor erlotinib is much less effective in non-small-cell lung cancer (NSCLC) tumors with wild-type EGFR, than…”
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Targeted inhibition of SCFSKP2 confers anti-tumor activities resulting in a survival benefit in osteosarcoma by Wang, Jichuan, Ferrena, Alexander, Zhang, Ranxin, Singh, Swapnil, Viscarret, Valentina, Al-Harden, Waleed, Aldahamsheh, Osama, Borjihan, Hasibagan, Singla, Amit, Yaguare, Simon, Tingling, Janet, Zi, Xiaolin, Lo, Yungtai, Gorlick, Richard, Schwartz, Edward L., Zhao, Hongling, Yang, Rui, Geller, David S., Zheng, Deyou, Hoang, Bang H.

“…Osteosarcoma(OS) is a highly aggressive bone cancer for which treatment has remained essentially unchanged for decades. Although OS is characterized by…”
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SKP2 Knockout in Rb1/p53-Deficient Mouse Models of Osteosarcoma Induces Immune Infiltration and Drives a Transcriptional Program with a Favorable Prognosis by Ferrena, Alexander, Wang, Jichuan, Zhang, Ranxin, Karadal-Ferrena, Burcu, Al-Hardan, Waleed, Singh, Swapnil, Borjihan, Hasibagan, Schwartz, Edward L, Zhao, Hongling, Oktay, Maja H, Yang, Rui, Geller, David S, Hoang, Bang H, Zheng, Deyou

“…Osteosarcoma is an aggressive bone malignancy with a poor prognosis. One putative proto-oncogene in osteosarcoma is SKP2, encoding a substrate recognition…”
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The interaction of SKP2 with p27 enhances the progression and stemness of osteosarcoma by Wang, Jichuan, Aldahamsheh, Osama, Ferrena, Alexander, Borjihan, Hasibagan, Singla, Amit, Yaguare, Simon, Singh, Swapnil, Viscarret, Valentina, Tingling, Janet, Zi, Xiaolin, Lo, Yungtai, Gorlick, Richard, Zheng, Deyou, Schwartz, Edward L., Zhao, Hongling, Yang, Rui, Geller, David S., Hoang, Bang H.

“…Osteosarcoma is a highly aggressive malignancy for which treatment has remained essentially unchanged for years. Our previous studies found that the F‐box…”
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VarCLR: Variable Semantic Representation Pre-training via Contrastive Learning by Chen, Qibin, Lacomis, Jeremy, Schwartz, Edward J., Neubig, Graham, Vasilescu, Bogdan, Goues, Claire Le

“…Variable names are critical for conveying intended program behavior. Machine learning-based program analysis methods use variable name representations for a…”
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RICTOR Amplification Defines a Novel Subset of Patients with Lung Cancer Who May Benefit from Treatment with mTORC1/2 Inhibitors by Cheng, Haiying, Zou, Yiyu, Ross, Jeffrey S, Wang, Kai, Liu, Xuewen, Halmos, Balazs, Ali, Siraj M, Liu, Huijie, Verma, Amit, Montagna, Cristina, Chachoua, Abraham, Goel, Sanjay, Schwartz, Edward L, Zhu, Changcheng, Shan, Jidong, Yu, Yiting, Gritsman, Kira, Yelensky, Roman, Lipson, Doron, Otto, Geoff, Hawryluk, Matthew, Stephens, Philip J, Miller, Vincent A, Piperdi, Bilal, Perez-Soler, Roman

“…We identified amplification of RICTOR, a key component of the mTOR complex 2 (mTORC2), as the sole actionable genomic alteration in an 18-year-old never-smoker…”
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Genome sequence of the bioplastic-producing "Knallgas" bacterium Ralstonia eutropha H16 by Friedrich, Bärbel, Pohlmann, Anne, Fricke, Wolfgang Florian, Reinecke, Frank, Kusian, Bernhard, Liesegang, Heiko, Cramm, Rainer, Eitinger, Thomas, Ewering, Christian, Pötter, Markus, Schwartz, Edward, Strittmatter, Axel, Voß, Ingo, Gottschalk, Gerhard, Steinbüchel, Alexander, Bowien, Botho

“…The H(2)-oxidizing lithoautotrophic bacterium Ralstonia eutropha H16 is a metabolically versatile organism capable of subsisting, in the absence of organic…”
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Superfluid spin transistor by Schwartz, Edward, Li, Bo, Kovalev, Alexey A.

“…We propose to use the Hall response of topological defects, such as merons and antimerons, to spin currents in two-dimensional magnetic insulator with in-plane…”
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Skp2 depletion reduces tumor-initiating properties and promotes apoptosis in synovial sarcoma by Wang, Jichuan, Sato, Kenji, O'Donnell, Ed, Singla, Amit, Yaguare, Simon, Aldahamsheh, Osama, Batko, Brian, Borjihan, Hasibagan, Tingling, Janet, Zhang, Jinghang, Weiser, Daniel A., Loeb, David M., Gorlick, Richard, Schwartz, Edward L., Yang, Rui, Zi, Xiaolin, Zhao, Hongling, Geller, David S., Hoang, Bang H.

“…Synovial sarcoma (SS) is an aggressive soft-tissue cancer with a poor prognosis and a propensity for local recurrence and distant metastasis. In this study, we…”
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Taxotere-induced inhibition of human endothelial cell migration is a result of heat shock protein 90 degradation by Murtagh, Janice, Lu, Haiyan, Schwartz, Edward L

“…In addition to effects on tumor cell proliferation and apoptosis, microtubule-binding agents are potent inhibitors of angiogenesis. The cancer chemotherapeutic…”
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A randomized clinical trial of regional cerebral perfusion versus deep hypothermic circulatory arrest: Outcomes for infants with functional single ventricle by Goldberg, Caren S., MD, Bove, Edward L., MD, Devaney, Eric J., MD, Mollen, Eileen, PhD, Schwartz, Edward, PhD, Tindall, Shauna, PhD, Nowak, Cheryl, RN, Charpie, John, MD, Brown, Morton B., PhD, Kulik, Tom J., MD, Ohye, Richard G., MD

“…Objective Regional cerebral perfusion has been adopted as a means to improve neuroprotection during aortic arch reconstruction. The purpose of this study was…”
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Autotrophic Production of Stable-Isotope-Labeled Arginine in Ralstonia eutropha Strain H16 by Lütte, Steffen, Pohlmann, Anne, Zaychikov, Evgeny, Schwartz, Edward, Becher, Johannes R, Heumann, Hermann, Friedrich, Bärbel

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Discovery of Autophagy Inhibitors with Antiproliferative Activity in Lung and Pancreatic Cancer Cells by Nordstrøm, Lars Ulrik, Sironi, Juan, Aranda, Evelyn, Maisonet, Jorge, Perez-Soler, Roman, Wu, Peng, Schwartz, Edward L

“…The autophagy inhibitors chloroquine (CQ) and hydroxychloroquine (HCQ) have single agent antiproliferative activity against human cancer cell lines; however,…”
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