Search Results - "Schwartz, Daniella M"

JAK–STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects by Banerjee, Shubhasree, Biehl, Ann, Gadina, Massimo, Hasni, Sarfaraz, Schwartz, Daniella M.

“…The Janus kinase/signal transduction and activator of transcription (JAK–STAT) signaling pathway is implicated in the pathogenesis of inflammatory and…”
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JAK inhibition as a therapeutic strategy for immune and inflammatory diseases by Schwartz, Daniella M., Kanno, Yuka, Villarino, Alejandro, Ward, Michael, Gadina, Massimo, O'Shea, John J.

“…Key Points Despite their success, conventional and biologic disease-modifying antirheumatic drugs are not effective in all patients. First-generation Janus…”
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The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention by O'Shea, John J, Schwartz, Daniella M, Villarino, Alejandro V, Gadina, Massimo, McInnes, Iain B, Laurence, Arian

“…The Janus kinase (JAK)-signal transducer of activators of transcription (STAT) pathway is now recognized as an evolutionarily conserved signaling pathway…”
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Janus kinases to jakinibs: from basic insights to clinical practice by Gadina, Massimo, Le, Mimi T, Schwartz, Daniella M, Silvennoinen, Olli, Nakayamada, Shingo, Yamaoka, Kunihiro, O'Shea, John J

“…Abstract Cytokines are critical mediators of diverse immune and inflammatory diseases. Targeting cytokines and cytokine receptors with biologics has…”
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Locus of (IL-9) control: IL9 epigenetic regulation in cellular function and human disease by Son, Aran, Baral, Ishita, Falduto, Guido H., Schwartz, Daniella M.

“…Interleukin-9 (IL-9) is a multifunctional cytokine with roles in a broad cross-section of human diseases. Like many cytokines, IL-9 is transcriptionally…”
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The Interactions Between Autoinflammation and Type 2 Immunity: From Mechanistic Studies to Epidemiologic Associations by Sylvester, McKella, Son, Aran, Schwartz, Daniella M

“…Autoinflammatory diseases are a group of clinical syndromes characterized by constitutive overactivation of innate immune pathways. This results in increased…”
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Retinoic Acid Receptor Alpha Represses a Th9 Transcriptional and Epigenomic Program to Reduce Allergic Pathology by Schwartz, Daniella M., Farley, Taylor K., Richoz, Nathan, Yao, Chen, Shih, Han-Yu, Petermann, Franziska, Zhang, Yuan, Sun, Hong-Wei, Hayes, Erika, Mikami, Yohei, Jiang, Kan, Davis, Fred P., Kanno, Yuka, Milner, Joshua D., Siegel, Richard, Laurence, Arian, Meylan, Françoise, O’Shea, John J.

“…CD4+ T helper (Th) differentiation is regulated by diverse inputs, including the vitamin A metabolite retinoic acid (RA). RA acts through its receptor RARα to…”
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Brief Report: Drugs Implicated in Systemic Autoimmunity Modulate Neutrophil Extracellular Trap Formation by Irizarry‐Caro, Jorge A., Carmona‐Rivera, Carmelo, Schwartz, Daniella M., Khaznadar, Sami S., Kaplan, Mariana J., Grayson, Peter C.

“…Objective Aberrant neutrophil extracellular trap (NET) formation has been implicated as a mechanism to induce autoreactivity in individuals at risk of…”
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PET/CT-Based Characterization of 18F-FDG Uptake in Various Tissues Reveals Novel Potential Contributions to Coronary Artery Disease in Psoriatic Arthritis by Schwartz, Daniella M., Parel, Philip, Li, Haiou, Sorokin, Alexander V., Berg, Alexander R., Chen, Marcus, Dey, Amit, Hong, Christin G., Playford, Martin, Sylvester, McKella, Teague, Heather, Siegel, Evan, Mehta, Nehal N.

“…Background and Objectives Psoriasis is a heterogeneous inflammatory disease that involves the skin, joints, liver, heart, and other organs. Psoriatic arthritis…”
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CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies by SHUANG CHEN, YUN DAI, RICHEY, Justin D, LARSEN, Dustin G, DENT, Paul, ORLOWSKI, Robert Z, GRANT, Steven, PEI, Xin-Yan, MYERS, Jennifer, LI WANG, KRAMER, Lora B, GARNETT, Mandy, SCHWARTZ, Daniella M, SU, Florence, SIMMONS, Gary L

“…BH3 mimetic drugs induce cell death by antagonizing the activity of antiapoptotic Bcl-2 family proteins. Cyclin-dependent kinase (CDK) inhibitors that function…”
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Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases by Schwartz, Daniella M., Bonelli, Michael, Gadina, Massimo, O'Shea, John J.

“…Key Points Cytokines are major drivers of autoimmunity, and targeting cytokines has revolutionized the treatment of rheumatologic diseases Despite their…”
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JAK inhibition as a therapeutic strategy for immune and inflammatory diseases by Schwartz, Daniella M, Kanno, Yuka, Villarino, Alejandro, Ward, Michael, Gadina, Massimo, O'Shea, John J

“…This corrects the article DOI: 10.1038/nrd.2017.201…”
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Transcriptomic analysis reveals optimal cytokine combinations for SARS-CoV-2-specific T cell therapy products by Durkee-Shock, Jessica, Lazarski, Christopher A., Jensen-Wachspress, Mariah A., Zhang, Anqing, Son, Aran, Kankate, Vaishnavi V., Field, Naomi E., Webber, Kathleen, Lang, Haili, Conway, Susan R., Hanley, Patrick J., Bollard, Catherine M., Keller, Michael D., Schwartz, Daniella M.

“…Adoptive T cell immunotherapy has been used to restore immunity against multiple viral targets in immunocompromised patients after bone-marrow transplantation…”
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JAK-STAT signaling in human disease: From genetic syndromes to clinical inhibition by Luo, Yiming, Alexander, Madison, Gadina, Massimo, O’Shea, John J., Meylan, Francoise, Schwartz, Daniella M.

“…Since its discovery, the Janus kinase-signal transduction and activation of transcription (JAK-STAT) pathway has become recognized as a central mediator of…”
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From thymus to tissues and tumors: A review of T-cell biology by Chopp, Laura, Redmond, Christopher, O’Shea, John J., Schwartz, Daniella M.

“…T cells are critical orchestrators of the adaptive immune response that optimally eliminate a specific pathogen. Aberrant T-cell development and function are…”
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Palmoplantar pustules and osteoarticular pain in a 42-year-old woman by Zuo, Rena C., BA, Schwartz, Daniella M., MD, Lee, Chyi-Chia Richard, MD, PhD, Anadkat, Milan J., MD, Cowen, Edward W., MD, MHSc, Naik, Haley B., MD

“…Key teaching points • Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is characterized by distinctive osteoarticular manifestations and a…”
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The Complexity of Being A20: From Biological Functions to Genetic Associations by Karri, Urekha, Harasimowicz, Magdalena, Carpio Tumba, Manuel, Schwartz, Daniella M.

“…A20, encoded by TNFAIP3 , is a critical negative regulator of immune activation. A20 is a ubiquitin editing enzyme with multiple domains, each of which…”
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Stepping off the beaten path: A multiomic atlas uncovers novel trajectories of T-cell exhaustion by Falduto, Guido H, Schwartz, Daniella M

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A20 haploinsufficiency (HA20): clinical phenotypes and disease course of patients with a newly recognised NF-kB-mediated autoinflammatory disease by Aeschlimann, Florence A, Batu, Ezgi D, Canna, Scott W, Go, Ellen, Gül, Ahmet, Hoffmann, Patrycja, Leavis, Helen L, Ozen, Seza, Schwartz, Daniella M, Stone, Deborah L, van Royen-Kerkof, Annet, Kastner, Daniel L, Aksentijevich, Ivona, Laxer, Ronald M

“…The association between mutations in , encoding the NF-kB regulatory protein A20, and a new autoinflammatory disease has recently been recognised. This study…”
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Orai1-Mediated Antimicrobial Secretion from Pancreatic Acini Shapes the Gut Microbiome and Regulates Gut Innate Immunity by Ahuja, Malini, Schwartz, Daniella M., Tandon, Mayank, Son, Aran, Zeng, Mei, Swaim, William, Eckhaus, Michael, Hoffman, Victoria, Cui, Yiyuan, Xiao, Bo, Worley, Paul F., Muallem, Shmuel

“…The gut microbiome participates in numerous physiologic functions and communicates intimately with the host immune system. Antimicrobial peptides are critical…”
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