Search Results - "Schwartz, D R"

CYP1A1 and CYP1B1 polymorphisms and risk of lung cancer among never smokers: a population-based study by Wenzlaff, A.S., Cote, M.L., Bock, C.H., Land, S.J., Santer, S.K., Schwartz, D.R., Schwartz, A.G.

“…The cytochrome P450 (CYP) superfamily of enzymes catalyse one of the first steps in the metabolism of carcinogens such as polycyclic aromatic hydrocarbons,…”
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Combinations of cytochrome P-450 genotypes and risk of early-onset lung cancer in Caucasians and African Americans: A population-based study by Cote, M.L, Wenzlaff, A.S, Bock, C.H, Land, S.J, Santer, S.K, Schwartz, D.R, Schwartz, A.G

“…Summary Polymorphisms in CYP1A1 and CYP1B1 genes in humans are associated with reduction of enzymatic activity towards several substrates, including those…”
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Negative pressure pulmonary hemorrhage by Schwartz, D R, Maroo, A, Malhotra, A, Kesselman, H

“…Negative pressure pulmonary edema, a well-recognized phenomenon, is the formation of pulmonary edema following an acute upper airway obstruction (UAO). To our…”
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Benzodiazepines protect hippocampal neurons from degeneration after transient cerebral ischemia: an ultrastructural study by Schwartz-Bloom, R.D., Miller, K.A., Evenson, D.A., Crain, B.J., Nadler, J.V.

“…The ability of full and partial benzodiazepine receptor agonists to prevent DNA fragmentation and neuronal death after transient cerebral ischemia was…”
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Ethanol Stimulates γ -aminobutyric Acid Receptor-Mediated Chloride Transport in Rat Brain Synaptoneurosomes by Suzdak, Peter D., Schwartz, Rochelle D., Skolnick, Phil, Paul, Steven M.

“…The effects of ethanol on Cl- uptake were studied using a cell-free subcellular preparation from brain that contains a γ -aminobutyric acid (GABA)/barbiturate…”
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Steroid Hormone Metabolites are Barbiturate-Like Modulators of the GABA Receptor by Majewska, Maria Dorota, Harrison, Neil L., Schwartz, Rochelle D., Barker, Jeffery L., Paul, Steven M.

“…Two metabolites of the steroid hormones progesterone and deoxycorticosterone, 3α-hydroxy-5α-dihydroprogesterone and 3α,5α-tetrahydrodeoxycorticosterone, are…”
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Protective efficacy of a recombinant herpesvirus of turkeys as an in ovo vaccine against Newcastle and Marek's diseases in specific-pathogen-free chickens by Reddy, S.K., Sharma, J.M., Ahmad, J., Reddy, D.N., McMillen, J.K., Cook, S.M., Wild, M.A., Schwartz, R.D.

“…We investigated the potential of a herpesvirus of turkey (HVT)-based recombinant virus (rHVT) as an in in ovo vaccine to protect specific-pathogen-free…”
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cAMP and Forskolin Decrease γ -aminobutyric Acid-Gated Chloride Flux in Rat Brain Synaptoneurosomes by Heuschneider, Gunter, Schwartz, Rochelle D.

“…The effects of the cyclic nucleotide cAMP on γ -aminobutyric acid-gated chloride channel function were investigated. The membrane-permeant cAMP analog N6, O2′…”
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Pregnenolone-sulfate: an endogenous antagonist of the gamma-aminobutyric acid receptor complex in brain? by Majewska, M D, Schwartz, R D

“…The interaction of the 'neurosteroid', pregnenolone-sulfate (PS), with the GABA/benzodiazepine/chloride ionophore receptor complex was investigated in rat…”
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Nicotinic binding in rat brain: autoradiographic comparison of [3H]acetylcholine, [3H]nicotine, and [125I]-alpha-bungarotoxin by Clarke, PB, Schwartz, RD, Paul, SM, Pert, CB, Pert, A

“…Three radioligands have been commonly used to label putative nicotinic cholinoceptors in the mammalian central nervous system: the agonists [3H]nicotine and…”
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The GABAA receptor-gated ion channel: biochemical and pharmacological studies of structure and function by Schwartz, R D

“…In the past few years, substantial advances have been made in analyzing the structure and function of the GABA receptor-gated Cl- channel. A major goal is to…”
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Coordinately up-regulated genes in ovarian cancer by HOUGH, Colleen D, CHO, Kathleen R, ZONDERMAN, Alan B, SCHWARTZ, Donald R, MORIN, Patrice J

“…A better understanding of the molecular circuitry in normal ovarian tissues and in ovarian cancer will likely provide new targets for diagnosis and therapy…”
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A Selective Imidazobenzodiazepine Antagonist of Ethanol in the Rat by Suzdak, Peter D., Glowa, John R., Crawley, Jacqueline N., Schwartz, Rochelle D., Skolnick, Phil, Paul, Steven M.

“…Ethanol, at pharmacologically relevant concentrations of 20 to 100 mM, stimulates $\gamma $-aminobutyric (GABA) receptor-mediated uptake of $^{36}$Cl-labeled…”
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Prenatal exposure to nicotine impairs nervous system development at a dose which does not affect viability or growth by Navarro, H A, Seidler, F J, Schwartz, R D, Baker, F E, Dobbins, S S, Slotkin, T A

“…Prenatal exposure to high doses of nicotine (greater than 6 mg/kg/day) via maternal infusions has been shown to impair nervous system development and to…”
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Neoplasia and Granulomas Surrounding Microchip Transponders in Damaraland Mole Rats (Cryptomys damarensis) by Sura, R., French, R. A., Goldman, B. D., Schwartz, D. R.

“…Damaraland mole rats (Cryptomys damarensis) are among the longest-living rodents, with a maximum longevity of approximately 16 years. As one of the few mammals…”
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Microcirculatory weak units--an alternative explanation by Schwartz, D R, Malhotra, A, Fink, M P

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Diazepam Promotes ATP Recovery and Prevents Cytochrome c Release in Hippocampal Slices After In Vitro Ischemia by Galeffi, Francesca, Sinnar, Shamim, Schwartz‐Bloom, Rochelle D.

“…: Benzodiazepines protect hippocampal neurons when administered within the first few hours after transient cerebral ischemia. Here, we examined the ability of…”
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Human cytotoxic T-cell lines with restricted specificity for squamous cell carcinoma of the head and neck by YASUMURA, S, HIRABAYASHI, H, SCHWARTZ, D. R, TOSO, J. F, JOHNSON, J. T, HERBERMAN, R. B, WHITESIDE, T. L

“…Human cytotoxic T-lymphocyte (CTL) lines with specificity restricted for autologous squamous cell carcinoma of the head and neck (SCCHN) were established from…”
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The use of locomotor activity as a behavioral screen for neuronal damage following transient forebrain ischemia in gerbils by Mileson, B E, Schwartz, R D

“…Five min bilateral carotid artery occlusion (BCO) in gerbils results in selective degeneration of neurons in the hippocampus, striatum and cortex, and an…”
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Functionally relevant gamma-aminobutyric acidA receptors: equivalence between receptor affinity (Kd) and potency (EC50)? by Edgar, P P, Schwartz, R D

“…Many neurotransmitter receptors bind agonists with high affinity (Kd in the nanomolar range), whereas micromolar concentrations of the same agonists are…”
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