Search Results - "Schwark, Manuela"
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Ultrastructural Imaging of Activity-Dependent Synaptic Membrane-Trafficking Events in Cultured Brain Slices
Published in Neuron (Cambridge, Mass.) (09-12-2020)“…Electron microscopy can resolve synapse ultrastructure with nanometer precision, but the capture of time-resolved, activity-dependent synaptic…”
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The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc
Published in Molecular psychiatry (01-06-2021)“…Kaufman oculocerebrofacial syndrome (KOS) is a severe autosomal recessive disorder characterized by intellectual disability, developmental delays,…”
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Satb2 Is a Postmitotic Determinant for Upper-Layer Neuron Specification in the Neocortex
Published in Neuron (Cambridge, Mass.) (07-02-2008)“…Pyramidal neurons of the neocortex can be subdivided into two major groups: deep- (DL) and upper-layer (UL) neurons. Here we report that the expression of the…”
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Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140
Published in Neuron (Cambridge, Mass.) (05-12-2018)“…The establishment of axon-dendrite polarity is fundamental for radial migration of neurons during cortex development of mammals. We demonstrate that the E3…”
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FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons
Published in The EMBO journal (20-07-2011)“…Netrin‐1 induces repulsive axon guidance by binding to the mammalian Unc5 receptor family (Unc5A–Unc5D). Mouse genetic analysis of selected members of the Unc5…”
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Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis
Published in Proceedings of the National Academy of Sciences - PNAS (05-04-2011)“…Neural stem cells (NSCs) generate new granule cells throughout life in the mammalian hippocampus. Canonical Wnt signaling regulates the differentiation of NSCs…”
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Pax6 regulates craniofacial form through its control of an essential cephalic ectodermal patterning center
Published in Genesis (New York, N.Y. : 2000) (01-04-2011)“…Normal patterning and morphogenesis of the complex skeletal structures of the skull requires an exquisite, reciprocal cross‐talk between the embryonic cephalic…”
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Super-resolved 3D-STED microscopy identifies a layer-specific increase in excitatory synapses in the hippocampal CA1 region of Neuroligin-3 KO mice
Published in Biochemical and biophysical research communications (10-12-2021)“…The chemical synapse is one type of cell-adhesion system that transmits information from a neuron to another neuron in the complex neuronal network in the…”
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Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity
Published in The Journal of cell biology (01-01-2024)“…Nedd4-2 is an E3 ubiquitin ligase in which missense mutation is related to familial epilepsy, indicating its critical role in regulating neuronal network…”
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Satb2 Haploinsufficiency Phenocopies 2q32-q33 Deletions, whereas Loss Suggests a Fundamental Role in the Coordination of Jaw Development
Published in American journal of human genetics (01-10-2006)“…The recent identification of SATB2 as a candidate gene responsible for the craniofacial dysmorphologies associated with deletions and translocations at…”
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FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons: FLRT2/3 as repulsive guidance cues for Unc5s
Published in The EMBO journal (20-07-2011)Get full text
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FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons
Published in Neuroscience research (01-09-2011)Get full text
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Article: Satb2 Is a Postmitotic Determinant for Upper-Layer Neuron Specification in the Neocortex
Published in Neuron (Cambridge, Mass.) (01-02-2008)“…Pyramidal neurons of the neocortex can be subdivided into two major groups: deep- (DL) and upper-layer (UL) neurons. Here we report that the expression of the…”
Get full text
Journal Article -
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