Search Results - "Schwanekamp, Jennifer A."

The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart by Kwong, Jennifer Q., Lu, Xiyuan, Correll, Robert N., Schwanekamp, Jennifer A., Vagnozzi, Ronald J., Sargent, Michelle A., York, Allen J., Zhang, Jianyi, Bers, Donald M., Molkentin, Jeffery D.

“…In the heart, augmented Ca2+ fluxing drives contractility and ATP generation through mitochondrial Ca2+ loading. Pathologic mitochondrial Ca2+ overload with…”
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A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy by Davis, Jennifer, Davis, L. Craig, Correll, Robert N., Makarewich, Catherine A., Schwanekamp, Jennifer A., Moussavi-Harami, Farid, Wang, Dan, York, Allen J., Wu, Haodi, Houser, Steven R., Seidman, Christine E., Seidman, Jonathan G., Regnier, Michael, Metzger, Joseph M., Wu, Joseph C., Molkentin, Jeffery D.

“…The heart either hypertrophies or dilates in response to familial mutations in genes encoding sarcomeric proteins, which are responsible for contraction and…”
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Deletion of Periostin Protects Against Atherosclerosis in Mice by Altering Inflammation and Extracellular Matrix Remodeling by Schwanekamp, Jennifer A, Lorts, Angela, Vagnozzi, Ronald J, Vanhoutte, Davy, Molkentin, Jeffery D

“…OBJECTIVE—Periostin is a secreted protein that can alter extracellular matrix remodeling in response to tissue injury. However, the functional role of…”
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Deletion of periostin reduces muscular dystrophy and fibrosis in mice by modulating the transforming growth factor-β pathway by Lorts, Angela, Schwanekamp, Jennifer A, Baudino, Troy A, McNally, Elizabeth M, Molkentin, Jeffery D

“…The muscular dystrophies are broadly classified as muscle wasting diseases with myofiber dropout due to cellular necrosis, inflammation, alterations in…”
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TGFBI functions similar to periostin but is uniquely dispensable during cardiac injury by Schwanekamp, Jennifer A, Lorts, Angela, Sargent, Michelle A, York, Allen J, Grimes, Kelly M, Fischesser, Demetria M, Gokey, Jason J, Whitsett, Jeffrey A, Conway, Simon J, Molkentin, Jeffery D

“…Extracellular matrix production and accumulation stabilize the heart under normal conditions as well as form a protective scar after myocardial infarction…”
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Exposure to lead-free frangible firing emissions containing copper and ultrafine particulates leads to increased oxidative stress in firing range instructors by McNeilly, Ryan J, Schwanekamp, Jennifer A, Hyder, Logan S, Hatch, John P, Edwards, Brett T, Kirsh, Jacob A, Jackson, Jerimiah M, Jaworek, Thomas, Methner, Mark M, Duran, Christin M

“…Since the introduction of copper based, lead-free frangible (LFF) ammunition to Air Force small arms firing ranges, instructors have reported symptoms…”
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An acute immune response underlies the benefit of cardiac stem cell therapy by Vagnozzi, Ronald J., Maillet, Marjorie, Sargent, Michelle A., Khalil, Hadi, Johansen, Anne Katrine Z., Schwanekamp, Jennifer A., York, Allen J., Huang, Vincent, Nahrendorf, Matthias, Sadayappan, Sakthivel, Molkentin, Jeffery D.

“…Clinical trials using adult stem cells to regenerate damaged heart tissue continue to this day 1 , 2 , despite ongoing questions of efficacy and a lack of…”
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The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle by Kwong, Jennifer Q., Huo, Jiuzhou, Bround, Michael J., Boyer, Justin G., Schwanekamp, Jennifer A., Ghazal, Nasab, Maxwell, Joshua T., Jang, Young C., Khuchua, Zaza, Shi, Kevin, Bers, Donald M., Davis, Jennifer, Molkentin, Jeffery D.

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Genetic Manipulation of Periostin Expression in the Heart Does Not Affect Myocyte Content, Cell Cycle Activity, or Cardiac Repair by Lorts, Angela, Schwanekamp, Jennifer A, Elrod, John W, Sargent, Michelle A, Molkentin, Jeffery D

“…Following a pathological insult, the adult mammalian heart undergoes hypertrophic growth and remodeling of the extracellular matrix. Although a small…”
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The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle by Kwong, Jennifer Q, Huo, Jiuzhou, Bround, Michael J, Boyer, Justin G, Schwanekamp, Jennifer A, Ghazal, Nasab, Maxwell, Joshua T, Jang, Young C, Khuchua, Zaza, Shi, Kevin, Bers, Donald M, Davis, Jennifer, Molkentin, Jeffery D

“…The mitochondrial Ca2+ uniporter (MCU) complex mediates acute mitochondrial Ca2+ influx. In skeletal muscle, MCU links Ca2+ signaling to energy production by…”
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A new method to remove hybridization bias for interspecies comparison of global gene expression profiles uncovers an association between mRNA sequence divergence and differential gene expression in Xenopus by Sartor, Maureen A., Zorn, Aaron M., Schwanekamp, Jennifer A., Halbleib, Danielle, Karyala, Saikumar, Howell, Michael L., Dean, Gary E., Medvedovic, Mario, Tomlinson, Craig R.

“…The recent sequencing of a large number of Xenopus tropicalis expressed sequences has allowed development of a high-throughput approach to study Xenopus global…”
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Association of Cardiomyopathy With MYBPC3 D389V and MYBPC3Δ25bpIntronic Deletion in South Asian Descendants by Viswanathan, Shiv Kumar, Puckelwartz, Megan J, Mehta, Ashish, Ramachandra, Chrishan J A, Jagadeesan, Aravindakshan, Fritsche-Danielson, Regina, Bhat, Ratan V, Wong, Philip, Kandoi, Sangeetha, Schwanekamp, Jennifer A, Kuffel, Gina, Pesce, Lorenzo L, Zilliox, Michael J, Durai, U Nalla B, Verma, Rama Shanker, Molokie, Robert E, Suresh, Domodhar P, Khoury, Philip R, Thomas, Annie, Sanagala, Thriveni, Tang, Hak Chiaw, Becker, Richard C, Knöll, Ralph, Shim, Winston, McNally, Elizabeth M, Sadayappan, Sakthivel

“…The genetic variant MYBPC3Δ25bp occurs in 4% of South Asian descendants, with an estimated 100 million carriers worldwide. MYBPC3 Δ25bp has been linked to…”
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A role for Saccharomyces cerevisiae Chk1p in the response to replication blocks by Schollaert, Kaila L, Poisson, Julie M, Searle, Jennifer S, Schwanekamp, Jennifer A, Tomlinson, Craig R, Sanchez, Yolanda

“…Replication blocks and DNA damage incurred during S phase activate the S-phase and intra-S-phase checkpoint responses, respectively, regulated by the Atrp and…”
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Genome-wide analyses show that nuclear and cytoplasmic RNA levels are differentially affected by dioxin by Schwanekamp, Jennifer A., Sartor, Maureen A., Karyala, Saikumar, Halbleib, Danielle, Medvedovic, Mario, Tomlinson, Craig R.

“…The aryl hydrocarbon receptor (AHR) mounts the body's main molecular defense against environmental toxicants by inducing a battery of genes encoding xenobiotic…”
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Abstract 772: The Highly Prevalent 25bp Intronic Deletion in MYBPC3 is Benign Under Baseline Conditions by McNamara, James W, Schwanekamp, Jennifer A, Patel, Parth N, Viswanathan, Shiv K, Bohlooly, Mohammad, Madeyski-Bengtson, Katja, Knöll, Ralph, Seidman, Jonathan G, Seidman, Christine E, Sadayappan, Sakthivel

“…Abstract only Background: Hypertrophic cardiomyopathy (HCM) affects at least 1 in 500 people worldwide, and results in the thickening of the ventricular walls…”
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Abstract 373: The Molecular Consequence of a Polymorphic 25bp Deletion in Intron 32 of MYBPC3, Specific to South Asians by Schwanekamp, Jennifer A, Viswanathan, Shiv K, Patel, Parth N, Kandoi, Sangeetha, Bhat, Ratan, Verma, Rama S, Seidman, Christine E, Seidman, Jonathan G, Shim, Winston, Knöll, Ralph, Sadayappan, Sakthivel

“…Abstract only Background: MYBPC3 encodes cardiac myosin binding protein-C, which regulates sarcomeric stability and contractility. Previous work described a…”
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Deletion of periostin reduces muscular dystrophy and fibrosis in mice by modulating the transforming growth factor-[Beta] pathway by Lorts, Angela, Schwanekamp, Jennifer A, Baudino, Troy A, McNally, Elizabeth M, Molkentin, Jeffery D

“…The muscular dystrophies are broadly classified as muscle wasting diseases with myofiber dropout due to cellular necrosis, inflammation, alterations in…”
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Dissecting the Roles of Periostin and TGFBI in Cardiovascular Disease by Schwanekamp, Jennifer A

“…Deposition, maturation, and regulation of the extracellular matrix (ECM) are key components of the overall fibrotic response, which plays a major pathological…”
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