Search Results - "Schwam, H."

A comparison of L-671,152 and MK-927, two topically effective ocular hypotensive carbonic anhydrase inhibitors, in experimental animals by Sugrue, M F, Mallorga, P, Schwam, H, Baldwin, J J, Ponticello, G S

“…L-671,152 is a water-soluble, carbonic anhydrase inhibitor structurally similar to MK-927, a carbonic anhydrase inhibitor that, on topical administration,…”
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Topically active carbonic anhydrase inhibitors. 1. O-Acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide by Woltersdorf, O. W., Schwam, H., Bicking, J. B., Brown, S. L., DeSolms, S. J., Fishman, D. R., Graham, S. L., Gautheron, P. D., Hoffman, J. M.

“…A series of O-acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide (4, L-643,799) was prepared and the potential utility of each series member as a…”
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The nonenzymatic displacement of the sulfamoyl group from different classes of aromatic compounds by glutathione and cysteine by Conroy, C W, Schwam, H, Maren, T H

“…The rates of reaction for the nonenzymatic conjugation of reduced glutathione and L-cysteine to a series of 5-substituted 1,3,4-thiadiazole- and…”
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L‐662,583 is a topically effective ocular hypotensive carbonic anhydrase inhibitor in experimental animals by Sugrue, M.F., Gautheron, P., Mallorga, P., Nolan, T.E., Graham, S.L., Schwam, H., Shepard, K.L., Smith, R.L.

“…1 L‐662,583 was a potent inhibitor in vitro of purified, human erythrocyte carbonic anhydrase II, possessing an IC50 of 0.7 nm. The IC50 values for MK‐927,…”
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Preclinical studies on L-671,152, a topically effective ocular hypotensive carbonic anhydrase inhibitor by Sugrue, M F, Mallorga, P, Schwam, H, Baldwin, J J, Ponticello, G S

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MK-927: a topically active ocular hypotensive carbonic anhydrase inhibitor by Sugrue, M F, Gautheron, P, Grove, J, Mallorga, P, Viader, M P, Schwam, H, Baldwin, J J, Christy, M E, Ponticello, G S

“…MK-927 (dl-5,6-dihydro-4-(2-methylpropylamino)-4H-thieno(2,3b)thiopyra n-2-sulfonamide-7,7-dioxide hydrochloride) is a water soluble, carbonic anhydrase…”
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Inhibitors of glycolic acid oxidase. 4-Substituted 3-hydroxy-1H-pyrrole-2,5-dione derivatives by Rooney, C. S, Randall, W. C, Streeter, K. B, Ziegler, C, Cragoe, E. J, Schwam, H, Michelson, S. R, Williams, H. W. R, Eichler, E

“…An extensive series of novel 4-substituted 3-hydroxy-1H-pyrrole-2,5-dione derivatives has been prepared and studied as inhibitors of glycolic acid oxidase…”
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Inhibitors of glycolic acid oxidase. 4-Substituted-2,4-dioxobutanoic acid derivatives by Williams, H. W. R., Eichler, E., Randall, W. C., Rooney, C. S., Cragoe, E. J., Streeter, K. B., Schwam, H., Michelson, S. R., Patchett, A. A., Taub, D.

“…Fourteen new 4-substituted 2,4-dioxobutanoic acids have been synthesized. These compounds, all of which contain lipophilic 4-substituents, are potent…”
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Transfer RNA. 3. Reconstitution of alanine acceptor activity from fragments produced by specific cleavage of tRNA Ala-II at its anticodon by Imura, N, Schwam, H, Chambers, R W

“…This report describes experiments showing that tRNA(Ala) (II) can be cleaved specifically at the G residue of its anticodon to give "half" molecules in high…”
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Failure of thymopoietin, ubiquitin and synthetic serum thymic factor to restore immunocompetence in T-cell deficient mice by Martinez, D, Field, A K, Schwam, H, Tytell, A A, Hilleman, M R

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The Controlled Synthesis of Peptides in Aqueous Medium. I. The Use of α-Amino Acid N-Carboxyanhydrides by Denkewalter, Robert G, Schwam, H, Strachan, R. G, Beesley, Thomas E, Veber, Daniel F, Schoenewaldt, Erwin F, Barkemeyer, H, Paleveda, William J, Jacob, Theodore A, Hirschmann, Ralph

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Synthesis of peptides in aqueous medium. VII. Preparation and use of 2,5-thiazolidinediones in peptide synthesis by Hirschmann, Ralph, Dewey, R. S, Schoenewaldt, E. F, Joshua, H, Paleveda, William J, Schwam, H, Barkemeyer, H, Arison, Byron H, Veber, Daniel F

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Transfer RNA, I. Isolation and Characterization of a New Yeast Alanine Transfer RNA by Reeves, Robert H., Imura, Nobumasa, Schwam, Harvey, Weiss, Gary B., Schulman, LaDonne H., Chambers, Robert Warner

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Synthesis of peptides in aqueous medium. V. Preparation and use of 2,5-thiazolidinediones (NTA's). Use of the 13C-H nuclear magnetic resonance signal as internal standard for quantitative studies by Dewey, R. S, Schoenewaldt, E. F, Joshua, H, Paleveda, William J, Schwam, H, Barkemeyer, H, Arison, Byron H, Veber, Daniel F, Denkewalter, Robert G, Hirschmann, Ralph

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Thienothiopyran-2-sulfonamides: novel topically active carbonic anhydrase inhibitors for the treatment of glaucoma by Baldwin, John J, Ponticello, Gerald S, Anderson, Paul S, Christy, Marcia E, Murcko, Mark A, Randall, William C, Schwam, Harvey, Sugrue, Michael F, Gautheron, Pierre

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(Acyloxy)alkyl carbamates as novel bioreversible prodrugs for amines: increased permeation through biological membranes by Alexander, J, Cargill, R, Michelson, S R, Schwam, H

“…(Acyloxy)alkyl carbamates of the type R1R2N-CO-O-CHR3-OCO-R4 are described as novel bioreversible prodrugs for primary and secondary amines. These were…”
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New isomeric classes of topically active ocular hypotensive carbonic anhydrase inhibitors: 5-substituted thieno[2,3-b]thiophene-2-sulfonamides and 5-substituted thieno[3,2-b]thiophene-2-sulfonamides by Prugh, John D, Hartman, George D, Mallorga, Pierre J, McKeever, Brian M, Michelson, Stuart R, Murcko, Mark A, Schwam, Harvey, Smith, Robert L, Sondey, John M

“…A series of 5-substituted thieno[2,3-b]- and thieno[3,2-b)- and thieno[3,2-b)thiophene-2-sulfonamides was prepared and evaluated for topical ocular hypotensive…”
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Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity by Graham, Samuel L, Shepard, Kenneth L, Anderson, Paul S, Baldwin, John J, Best, Darryl B, Christy, Marcia E, Freedman, Mark B, Gautheron, Pierre, Habecker, Charles N

“…Derivatives of benzo[b]thiophene-2-sulfonamide were prepared to investigate their potential utility as topically active inhibitors of ocular carbonic…”
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Thienothiopyran-2-sulfonamides: a novel class of water-soluble carbonic anhydrase inhibitors by Ponticello, Gerald S, Freedman, Mark B, Habecker, Charles N, Lyle, Paulette A, Schwam, Harvey, Varga, Sandor L, Christy, Marcia E, Randall, William C, Baldwin, John J

“…An attempt to develop a water-soluble carbonic anhydrase inhibitor focused on exploring structure-activity relationships in the thienothiopyransulfonamide…”
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Sulfonylmethanesulfonamide inhibitors of carbonic anhydrase by Scholz, Thomas H, Sondey, John M, Randall, William C, Schwam, Harvey, Thompson, Wayne J, Mallorga, Pierre J, Sugrue, Michael F, Graham, Samuel L

“…A series of sulfonylmethanesulfonamide derivatives is described, which are inhibitors of carbonic anhydrase (CA). The most potent of these is the racemic…”
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