Search Results - "Schwacha, Anthony"

The Mcm Complex: Unwinding the Mechanism of a Replicative Helicase by Bochman, Matthew L, Schwacha, Anthony

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The Mcm2-7 Complex Has In Vitro Helicase Activity by Bochman, Matthew L., Schwacha, Anthony

“…Helicases unwind duplex DNA ahead of the polymerases at the replication fork. However, the identity of the eukaryotic replicative helicase has been…”
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The Mcm2-7 Replicative Helicase: A Promising Chemotherapeutic Target by Simon, Nicholas E., Schwacha, Anthony

“…Numerous eukaryotic replication factors have served as chemotherapeutic targets. One replication factor that has largely escaped drug development is the Mcm2-7…”
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A Checkpoint-Related Function of the MCM Replicative Helicase Is Required to Avert Accumulation of RNA:DNA Hybrids during S-phase and Ensuing DSBs during G2/M by Vijayraghavan, Sriram, Tsai, Feng-Ling, Schwacha, Anthony

“…The Mcm2-7 complex is the catalytic core of the eukaryotic replicative helicase. Here, we identify a new role for this complex in maintaining genome integrity…”
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Subunit Organization of Mcm2-7 and the Unequal Role of Active Sites in ATP Hydrolysis and Viability by Bochman, Matthew L., Bell, Stephen P., Schwacha, Anthony

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Interhomolog Bias during Meiotic Recombination: Meiotic Functions Promote a Highly Differentiated Interhomolog-Only Pathway by Schwacha, Anthony, Kleckner, Nancy

“…Meiotic recombination occurs preferentially between homologous nonsister chromatids rather than between sisters, opposite to the bias of mitotic…”
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Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate by Tsai, Feng-Ling, Vijayraghavan, Sriram, Prinz, Joseph, MacAlpine, Heather K., MacAlpine, David M., Schwacha, Anthony

“…The DNA replication checkpoint (DRC) monitors and responds to stalled replication forks to prevent genomic instability. How core replication factors integrate…”
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Validation of a high throughput screening assay to identify small molecules that target the eukaryotic replicative helicase by Sanders, Jordan, Castiglione, Michael, Shun, Tongying, Vollmer, Laura L., Schurdak, Mark E., Vogt, Andreas, Schwacha, Anthony

“…Mcm2-7 is the catalytic core of the eukaryotic replicative helicase, which together with CDC45 and the GINS complex unwind parental DNA to generate templates…”
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Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase by Simon, Nicholas, Bochman, Matthew L, Seguin, Sandlin, Brodsky, Jeffrey L, Seibel, William L, Schwacha, Anthony

“…Most currently available small molecule inhibitors of DNA replication lack enzymatic specificity, resulting in deleterious side effects during use in cancer…”
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Identification of double holliday junctions as intermediates in meiotic recombination by Schwacha, Anthony, Kleckner, Nancy

“…During meiosis, branched DNA molecules containing information from both parental chromosomes occur in vivo at loci where meiosis-specific double-stranded…”
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Interactions between Two Catalytically Distinct MCM Subgroups Are Essential for Coordinated ATP Hydrolysis and DNA Replication by Schwacha, Anthony, Bell, Stephen P

“…The six MCM (minichromosome maintenance) proteins are essential DNA replication factors that each contain a putative ATP binding motif and together form a…”
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Differences in the Single-stranded DNA Binding Activities of MCM2-7 and MCM467 by Bochman, Matthew L., Schwacha, Anthony

“…The MCM2-7 complex, a hexamer containing six distinct and essential subunits, is postulated to be the eukaryotic replicative DNA helicase. Although all six…”
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The eukaryotic Mcm2-7 replicative helicase by Vijayraghavan, Sriram, Schwacha, Anthony

“…In eukaryotes, the Mcm2-7 complex forms the core of the replicative helicase - the molecular motor that uses ATP binding and hydrolysis to fuel the unwinding…”
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Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 'gate' by Bochman, Matthew L, Schwacha, Anthony

“…The Mcm2-7 complex is the eukaryotic replicative helicase, a toroidal AAA⁺ molecular motor that uses adenosine triphosphate (ATP) binding and hydrolysis to…”
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DNA replication: Strand separation unravelled by Bochman, Matthew L, Schwacha, Anthony

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Differences in the Single-stranded DNA Binding Activities of MCM2-7 and MCM467: MCM2 AND MCM5 DEFINE A SLOW ATP-DEPENDENT STEP by Bochman, Matthew L, Schwacha, Anthony

“…The MCM2-7 complex, a hexamer containing six distinct and essential subunits, is postulated to be the eukaryotic replicative DNA helicase. Although all six…”
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Strand separation unravelled by Bochman, Matthew L., Schwacha, Anthony

“…The DNA double helix must be separated into single strands to be duplicated. A structure of the Mcm2–7 helicase enzyme responsible for this activity yields…”
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A High-Throughput Assay for DNA Replication Inhibitors Based upon Multivariate Analysis of Yeast Growth Kinetics by Ngo, Marilyn, Wechter, Nick, Tsai, Emily, Shun, Tong Ying, Gough, Albert, Schurdak, Mark E, Schwacha, Anthony, Vogt, Andreas

“…Mcm2-7 is the molecular motor of eukaryotic replicative helicase, and the regulation of this complex is a major focus of cellular S-phase regulation. Despite…”
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Identification of joint molecules that form frequently between homologs but rarely between sister chromatids during yeast meiosis by Schwacha, A, Kleckner, N

“…We have investigated DNA interactions between homologs and between sister chromatids during meiosis in S. cerevisiae. We have detected a DNA species containing…”
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Synaptonemal complex (SC) component Zip1 plays a role in meiotic recombination independent of SC polymerization along the chromosomes by Storlazzi, A. (Harvard University, Cambridge, MA.), Xu, L, Schwacha, A, Kleckner, N

“…Zip1 is a yeast synaptonemal complex (SC) central region component and is required for normal meiotic recombination and crossover interference. Physical…”
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