Search Results - "Schwab, Sibylle"

Genetic variation and susceptibility to schizophrenia: Work in progress by Schwab, Sibylle G

“…After finishing my pharmacy studies, I became interested in undertaking a PhD in the genetics of psychiatric disorders, specifically, the genetics of…”
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How stress physically re-shapes the brain: Impact on brain cell shapes, numbers and connections in psychiatric disorders by Kaul, Dominic, Schwab, Sibylle G., Mechawar, Naguib, Matosin, Natalie

“…•Severe stress exposure is a strong risk factor for psychopathology.•We consolidate evidence of how stress exposure can physically reshape the…”
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Alterations in Astrocytic Regulation of Excitation and Inhibition by Stress Exposure and in Severe Psychopathology by Kaul, Dominic, Schwab, Sibylle G, Mechawar, Naguib, Ooi, Lezanne, Matosin, Natalie

“…Dysregulation of excitatory and inhibitory signaling is commonly observed in major psychiatric disorders, including schizophrenia, depression, and bipolar…”
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Dissecting the molecular biology of schizophrenia: A call for emphasising genetic and phenotypic heterogeneity: commentary on Torrey and Yolken (this issue) by Schwab, Sibylle G.

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Understanding the pathology of psychiatric disorders in refugees by Bartlett, Rachael, Sarnyai, Zoltan, Momartin, Shakeh, Ooi, Lezanne, Schwab, Sibylle G., Matosin, Natalie

“…•Displaced people are stress-exposed and at increased risk for psychopathology.•We summarise studies into the pathology of psychiatric disorders in…”
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Cis-Expression Quantitative Trait Loci Mapping Reveals Replicable Associations with Heroin Addiction in OPRM1 by Hancock, Dana B, Levy, Joshua L, Gaddis, Nathan C, Glasheen, Cristie, Saccone, Nancy L, Page, Grier P, Hulse, Gary K, Wildenauer, Dieter, Kelty, Erin A, Schwab, Sibylle G, Degenhardt, Louisa, Martin, Nicholas G, Montgomery, Grant W, Attia, John, Holliday, Elizabeth G, McEvoy, Mark, Scott, Rodney J, Bierut, Laura J, Nelson, Elliot C, Kral, Alex H, Johnson, Eric O

“…Abstract Background No opioid receptor, mu 1 ( OPRM1 ) gene polymorphisms, including the functional single nucleotide polymorphism (SNP) rs1799971, have been…”
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Genetics of psychiatric disorders in the GWAS era: an update on schizophrenia by Schwab, Sibylle G., Wildenauer, Dieter B.

“…The influence of genetic factors in the development of schizophrenia has been convincingly demonstrated by family, twin, and adoption studies. The statistical…”
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Gut Microbiome Profiling of the Endangered Southern Greater Glider (Petauroides volans) after the 2019–2020 Australian Megafire by Clough, Jordyn, Schwab, Sibylle, Mikac, Katarina

“…Studying the gut microbiome can provide valuable insights into animal health and inform the conservation management of threatened wildlife. Gut microbiota play…”
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Severe childhood and adulthood stress associates with neocortical layer-specific reductions of mature spines in psychiatric disorders by Kaul, Dominic, Smith, Caine C., Stevens, Julia, Fröhlich, Anna S., Binder, Elisabeth B., Mechawar, Naguib, Schwab, Sibylle G., Matosin, Natalie

“…Severe stress exposure causes the loss of dendritic spines on cortical pyramidal neurons and induces psychiatric-like symptoms in rodent models. These effects…”
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Population Genetics of the Invasive Red Fox, Vulpes vulpes, in South-Eastern Australia by Watson, Kalynda M.-A., Mikac, Katarina M., Schwab, Sibylle G.

“…The use of genetic information in conservation biology has become more widespread with genetic information more readily available for non-model organisms. It…”
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DNA sequence variants of the FKBP5 gene are associated with unipolar depression by Zobel, Astrid, Schuhmacher, Anna, Jessen, Frank, Höfels, Susanne, von Widdern, Olrik, Metten, Martin, Pfeiffer, Ute, Hanses, Claudia, Becker, Tim, Rietschel, Marcella, Scheef, Lukas, Block, Wolfgang, Schild, Hans H., Maier, Wolfgang, Schwab, Sibylle G.

“…FKBP5 is a glucocorticoid receptor-regulating co-chaperone of hsp-90 and, therefore, is suggested to play a role in the regulation of the…”
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Support for Association of Schizophrenia with Genetic Variation in the 6p22.3 Gene, Dysbindin, in Sib-Pair Families with Linkage and in an Additional Sample of Triad Families by Schwab, Sibylle G., Knapp, Michael, Mondabon, Stephanie, Hallmayer, Joachim, Borrmann-Hassenbach, Margitta, Albus, Margot, Lerer, Bernard, Rietschel, Marcella, Trixler, Matyas, Maier, Wolfgang, Wildenauer, Dieter B.

“…Genetic variants in a gene on 6p22.3, dysbindin, have been shown recently to be associated with schizophrenia (Straub et al. 2002 a ). There is no doubt that…”
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Apoptotic engulfment pathway and schizophrenia by Chen, Xiangning, Sun, Cuie, Chen, Qi, O'Neill, F Anthony, Walsh, Dermot, Fanous, Ayman H, Chowdari, Kodavali V, Nimgaonkar, Vishwajit L, Scott, Adrian, Schwab, Sibylle G, Wildenauer, Dieter B, Che, Ronglin, Tang, Wei, Shi, Yongyong, He, Lin, Luo, Xiong-Jian, Su, Bing, Edwards, Todd L, Zhao, Zhongming, Kendler, Kenneth S

“…Apoptosis has been speculated to be involved in schizophrenia. In a previously study, we reported the association of the MEGF10 gene with the disease. In this…”
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Association of CamK2A genetic variants with transition time from occasional to regular heroin use in a sample of heroin-dependent individuals by Eirich, Antonia, Biermann, Teresa, Müller, Christian P, Kornhuber, Johannes, Benyamin, Beben, Hulse, Gary K, Wildenauer, Dieter B, Schwab, Sibylle G

“…OBJECTIVESSusceptibility to heroin dependence is strongly influenced by genetic factors with heritability estimates as high as 0.7. A number of genes, as well…”
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Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression by Hranilovic, Dubravka, Stefulj, Jasminka, Schwab, Sibylle, Borrmann-Hassenbach, Margitta, Albus, Margot, Jernej, Branimir, Wildenauer, Dieter

“…Two polymorphic regions of serotonin transporter (5-HTT) gene: a 44 base pair (bp) insertion/deletion in the promoter region (5-HTTLPR) and a 17 bp variable…”
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Secretion of Acid Sphingomyelinase is Affected by its Polymorphic Signal Peptide by Rhein, Cosima, Reichel, Martin, Mühle, Christiane, Rotter, Andrea, Schwab, Sibylle G., Kornhuber, Johannes

“…Background: Acid sphingomyelinase (ASM) catalyses the hydrolysis of sphingomyelin into ceramide, which acts as a lipid messenger that regulates important…”
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Neuregulin-1 haplotype HAPICE is associated with lower hippocampal volumes in schizophrenic patients and in non-affected family members by Gruber, Oliver, Falkai, Peter, Schneider-Axmann, Thomas, Schwab, Sibylle G, Wagner, Michael, Maier, Wolfgang

“…Abstract The neuregulin-1 (NRG1) gene on chromosome 8p has been suggested as a potential susceptibility gene for schizophrenia. The exact way in which genetic…”
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Further Evidence for Association of Variants in the AKT1 Gene with Schizophrenia in a Sample of European Sib-Pair Families by Schwab, Sibylle G., Hoefgen, Barbara, Hanses, Claudia, Hassenbach, Margitta Borrmann, Albus, Margot, Lerer, Bernard, Trixler, Matyas, Maier, Wolfgang, Wildenauer, Dieter B.

“…Involvement of AKT signaling pathways in schizophrenia has been recently suggested, on the basis of several lines of evidence. In addition to impairment of…”
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Sensorimotor Gating of Schizophrenia Patients Is Influenced by 5-HT2A Receptor Polymorphisms by Quednow, Boris B, Kühn, Kai-Uwe, Mössner, Rainald, Schwab, Sibylle G, Schuhmacher, Anna, Maier, Wolfgang, Wagner, Michael

“…Background Schizophrenia patients exhibit impairment in prepulse inhibition (PPI) of the acoustic startle response (ASR), suggesting a sensorimotor gating…”
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Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond by Gaddis, Nathan, Mathur, Ravi, Marks, Jesse, Zhou, Linran, Quach, Bryan, Waldrop, Alex, Levran, Orna, Agrawal, Arpana, Randesi, Matthew, Adelson, Miriam, Jeffries, Paul W., Martin, Nicholas G., Degenhardt, Louisa, Montgomery, Grant W., Wetherill, Leah, Lai, Dongbing, Bucholz, Kathleen, Foroud, Tatiana, Porjesz, Bernice, Runarsdottir, Valgerdur, Tyrfingsson, Thorarinn, Einarsson, Gudmundur, Gudbjartsson, Daniel F., Webb, Bradley Todd, Crist, Richard C., Kranzler, Henry R., Sherva, Richard, Zhou, Hang, Hulse, Gary, Wildenauer, Dieter, Kelty, Erin, Attia, John, Holliday, Elizabeth G., McEvoy, Mark, Scott, Rodney J., Schwab, Sibylle G., Maher, Brion S., Gruza, Richard, Kreek, Mary Jeanne, Nelson, Elliot C., Thorgeirsson, Thorgeir, Stefansson, Kari, Berrettini, Wade H., Gelernter, Joel, Edenberg, Howard J., Bierut, Laura, Hancock, Dana B., Johnson, Eric Otto

“…Opioid addiction (OA) is moderately heritable, yet only rs1799971, the A118G variant in OPRM1 , has been identified as a genome-wide significant association…”
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