Search Results - "Schwab, Luciana P"

O-GlcNAcylation Regulates Cancer Metabolism and Survival Stress Signaling via Regulation of the HIF-1 Pathway by Ferrer, Christina M., Lynch, Thomas P., Sodi, Valerie L., Falcone, John N., Schwab, Luciana P., Peacock, Danielle L., Vocadlo, David J., Seagroves, Tiffany N., Reginato, Mauricio J.

“…The hexosamine biosynthetic pathway elevates posttranslational addition of O-linked β-N-acetylglucosamine (O-GlcNAc) on intracellular proteins. Cancer cells…”
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ITGA6 is directly regulated by hypoxia-inducible factors and enriches for cancer stem cell activity and invasion in metastatic breast cancer models by Brooks, Danielle L Peacock, Schwab, Luciana P, Krutilina, Raisa, Parke, Deanna N, Sethuraman, Aarti, Hoogewijs, David, Schörg, Alexandra, Gotwald, Lauren, Fan, Meiyun, Wenger, Roland H, Seagroves, Tiffany N

“…Hypoxia-inducible factors (HIFs) are well-established mediators of tumor growth, the epithelial to mesenchymal transition (EMT) and metastasis. In several…”
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mTOR/MYC Axis Regulates O-GlcNAc Transferase Expression and O-GlcNAcylation in Breast Cancer by Sodi, Valerie L, Khaku, Sakina, Krutilina, Raisa, Schwab, Luciana P, Vocadlo, David J, Seagroves, Tiffany N, Reginato, Mauricio J

“…Cancers exhibit altered metabolism characterized by increased glucose and glutamine uptake. The hexosamine biosynthetic pathway (HBP) uses glucose and…”
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Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer by Schwab, Luciana P, Peacock, Danielle L, Majumdar, Debeshi, Ingels, Jesse F, Jensen, Laura C, Smith, Keisha D, Cushing, Richard C, Seagroves, Tiffany N

“…Overexpression of the oxygen-responsive transcription factor hypoxia-inducible factor 1α (HIF-1α) correlates with poor prognosis in breast cancer patients. The…”
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The Oncogene HER2/neu (ERBB2) Requires the Hypoxia-inducible Factor HIF-1 for Mammary Tumor Growth and Anoikis Resistance by Whelan, Kelly A., Schwab, Luciana P., Karakashev, Sergey V., Franchetti, Lisa, Johannes, Gregg J., Seagroves, Tiffany N., Reginato, Mauricio J.

“…ERBB2, a receptor tyrosine kinase amplified in breast cancer, is a well established regulator of tumor growth in vivo and anoikis resistance leading to…”
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HIF-Dependent CKB Expression Promotes Breast Cancer Metastasis, Whereas Cyclocreatine Therapy Impairs Cellular Invasion and Improves Chemotherapy Efficacy by Krutilina, Raisa I, Playa, Hilaire, Brooks, Danielle L, Schwab, Luciana P, Parke, Deanna N, Oluwalana, Damilola, Layman, Douglas R, Fan, Meiyun, Johnson, Daniel L, Yue, Junming, Smallwood, Heather, Seagroves, Tiffany N

“…The oxygen-responsive hypoxia inducible factor (HIF)-1 promotes several steps of the metastatic cascade. A hypoxic gene signature is enriched in…”
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Anti-matrix metalloproteinase-9 DNAzyme decreases tumor growth in the MMTV-PyMT mouse model of breast cancer by Hallett, Miranda A, Teng, Bin, Hasegawa, Hisashi, Schwab, Luciana P, Seagroves, Tiffany N, Pourmotabbed, Tayebeh

“…Despite continued improvements in diagnosis, surgical techniques, and chemotherapy, breast cancer patients are still overcome by cancer metastasis. Tumor cell…”
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Chemoprevention Activity of Dipyridamole in the MMTV-PyMT Transgenic Mouse Model of Breast Cancer by CHUNMEI WANG, SCHWAB, Luciana P, MEIYUN FAN, SEAGROVES, Tiffany N, BUOLAMWINI, John K

“…Dipyridamole (DPM) is widely used to prevent strokes and vascular thrombosis. Combination therapy of DPM and antimetabolites has shown synergistic anticancer…”
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Benzimidazole analogs as potent hypoxia inducible factor inhibitors: synthesis, biological evaluation, and profiling drug-like properties by Chen, Jianjun, Wang, Jin, Schwab, Luciana P, Park, Kyung-Tae, Seagroves, Tiffany N, Jennings, Lisa K, Miller, Duane D, Li, Wei

“…To develop potent HIF-1α inhibitors for potential treatment of cancer. Chemical synthesis, HIF-luciferase assay, cytotoxic assay, platelet aggregation assay,…”
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Macrophage response to high number of titanium particles is cytotoxic and COX-2 mediated and it is not affected by the particle's endotoxin content or the cleaning treatment by Schwab, Luciana P., Marlar, Justin, Hasty, Karen A., Smith, Richard A.

“…Periprosthetic osteolysis is a progressive deterioration of bone around prostheses resulting primarily from the presence of wear debris. Particulate material,…”
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VHL Deletion Impairs Mammary Alveologenesis but Is Not Sufficient for Mammary Tumorigenesis by Seagroves, Tiffany N, Peacock, Danielle L, Liao, Debbie, Schwab, Luciana P, Krueger, Robin, Handorf, Charles R, Haase, Volker H, Johnson, Randall S

“…Overexpression of hypoxia inducible factor-1 (HIF-1)α, which is common in most solid tumors, correlates with poor prognosis and high metastatic risk in breast…”
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Titanium particles and surface-bound LPS activate different pathways in IC-21 macrophages by Schwab, Luciana P., Xing, Zhiqing, Hasty, Karen A., Smith, Richard A.

“…It is still unknown if wear‐debris particles themselves induce osteolysis or if they serve a functional role as receptors for ligands that incite an…”
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Titanium particles that have undergone phagocytosis by macrophages lose the ability to activate other macrophages by Xing, Zhiqing, Schwab, Luciana P., Alley, Carie F., Hasty, Karen A., Smith, Richard A.

“…Titanium particles derived from the wear of the orthopaedic implant surfaces can activate macrophages to secrete cytokines and stimulate osteoclastic bone…”
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Abstract 4511: HIF-1-dependent regulation of creatine kinase metabolism promotes breast cancer invasion and metastasis by Barch, Hilaire, Brooks, Danielle L., Krutilina, Raya, Schwab, Luciana P., Parke, Deanna, Seagroves, Tiffany N.

“…Abstract Dysregulated tumor cell metabolism is a hallmark of cancer progression and therapeutic resistance. In a screen for Hypoxia-Inducible Factor…”
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Abstract 3885: ITGA6 (CD49F) is directly regulated by hypoxia-inducible factors by Peacock, Danielle L., Schwab, Luciana P., Seagroves, Tiffany N.

“…Abstract Introduction: In response to hypoxic stress, tumors must adapt to the hostile microenvironment by regulating angiogenesis, cellular metabolism, cell…”
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Abstract 5312: Identification of novel HIF-1-dependent target genes in a murine model of breast cancer by Peacock, Danielle L., Schwab, Luciana P., Smith, Keisha D., Cushing, Richard C., Seagroves, Tiffany N.

“…Abstract Introduction: Hypoxia is a hallmark of most solid tumors. Under hypoxic stress tumor cells adapt by regulating survival, metabolism and angiogenesis…”
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Hypoxia-inducible factor 1[alpha] promotes primary tumor growth and tumor-initiating cell activity in breast cancer by Schwab, Luciana P, Peacock, Danielle L, Majumdar, Debeshi, Ingels, Jesse F, Jensen, Laura C, Smith, Keisha D, Cushing, Richard C, Seagroves, Tiffany N

“…Introduction Overexpression of the oxygen-responsive transcription factor hypoxia-inducible factor 1[alpha] (HIF-1[alpha]) correlates with poor prognosis in…”
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