Search Results - "Schwab, Lara S. U."

Induction and antiviral activity of ferret myxovirus resistance (Mx) protein 1 against influenza A viruses by Farrukee, Rubaiyea, Schwab, Lara S. U., Barnes, James B., Brooks, Andrew G., Londrigan, Sarah L., Hartmann, Gunther, Zillinger, Thomas, Reading, Patrick C.

“…Myxovirus resistance (Mx) proteins are products of interferon stimulated genes (ISGs) and Mx proteins of different species have been reported to mediate…”
Get full text

Expression of a Functional Mx1 Protein Is Essential for the Ability of RIG-I Agonist Prophylaxis to Provide Potent and Long-Lasting Protection in a Mouse Model of Influenza A Virus Infection by Schwab, Lara S. U, Villalón-Letelier, Fernando, Tessema, Melkamu B, Londrigan, Sarah L, Brooks, Andrew G, Hurt, Aeron, Coch, Christoph, Zillinger, Thomas, Hartmann, Gunther, Reading, Patrick C

“…RIG-I is an innate sensor of RNA virus infection and its activation induces interferon-stimulated genes (ISGs). In vitro studies using human cells have…”
Get full text

Delayed and limited administration of the JAKinib tofacitinib mitigates chronic DSS-induced colitis by Seal, Rishav, Schwab, Lara S U, Chiarolla, Cristina M, Hundhausen, Nadine, Klose, Georg Heinrich, Reu-Hofer, Simone, Rosenwald, Andreas, Wiest, Johannes, Berberich-Siebelt, Friederike

“…In inflammatory bowel disease, dysregulated T cells express pro-inflammatory cytokines. Using a chronic azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced…”
Get full text

Immune imprinting in early life shapes cross-reactivity to influenza B virus haemagglutinin by Edler, Peta, Schwab, Lara S. U., Aban, Malet, Wille, Michelle, Spirason, Natalie, Deng, Yi-Mo, Carlock, Michael A., Ross, Ted M., Juno, Jennifer A., Rockman, Steve, Wheatley, Adam K., Kent, Stephen J., Barr, Ian G., Price, David J., Koutsakos, Marios

“…Influenza exposures early in life are believed to shape future susceptibility to influenza infections by imprinting immunological biases that affect…”
Get full text

Dissemination of influenza B virus to the lower respiratory tract of mice is restricted by the interferon response by Schwab, Lara S U, Do, Thi H T, Pilapitiya, Devaki, Koutsakos, Marios

“…The global burden of disease caused by influenza B virus (IBV) is substantial; however, IBVs remain overlooked. Understanding host-pathogen interactions and…”
Get more information

Induction of Interferon-Stimulated Genes Correlates with Reduced Growth of Influenza A Virus in Lungs after RIG-I Agonist Treatment of Ferrets by Schwab, Lara S U, Londrigan, Sarah L, Brooks, Andrew G, Hurt, Aeron C, Sahu, Anshupa, Deng, Yi-Mo, Moselen, Jean, Coch, Christoph, Zillinger, Thomas, Hartmann, Gunther, Reading, Patrick C

“…Intracellular RIG-I receptors represent key innate sensors of RNA virus infection, and RIG-I activation results in the induction of hundreds of host effector…”
Get full text

Retinoic Acid-Inducible Gene I Activation Inhibits Human Respiratory Syncytial Virus Replication in Mammalian Cells and in Mouse and Ferret Models of Infection by Schwab, Lara S U, Farrukee, Rubaiyea, Eléouët, Jean-François, Rameix-Welti, Marie-Anne, Londrigan, Sarah L, Brooks, Andrew G, Hurt, Aeron C, Coch, Christoph, Zillinger, Thomas, Hartmann, Gunther, Reading, Patrick C

“…Infections caused by human respiratory syncytial virus (RSV) are associated with substantial rates of morbidity and mortality. Treatment options are limited,…”
Get full text