Search Results - "Schuurman, HJ"

Incidence of hyperacute rejection in pig-to-primate transplantation using organs from hDAF-transgenic donors by SCHUURMAN, Henk-Jan, PINO-CHAVEZ, Gilda, PHILLIPS, M. James, THOMAS, Lucy, WHITE, David J. G, COZZI, Emanuele

“…Cynomolgus monkeys or baboons received under immunosuppression kidney or heart grafts from pigs transgenic for human decay-accelerating factor (hDAF) or from…”
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The origin of cynomolgus monkey affects the outcome of kidney allografts under neoral immunosuppression by Menninger, K, Wieczorek, G, Riesen, S, Kunkler, A, Audet, M, Blancher, A, Schuurman, H.-J, Quesniaux, V, Bigaud, M

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Histopathology of the immune system as a tool to assess immunotoxicity by Schuurman, H J, Kuper, C F, Vos, J G

“…Immunotoxicology studies the undesired effects of interactions between xenobiotics and the immune system, mainly in toxicity experiments in rodents. The…”
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Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha 1,3- galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue by Yamada, Kazuhiko, Yazawa, Koji, Shimizu, Akira, Iwanaga, Takehiro, Hisashi, Yosuke, Nuhn, M, O'Malley, P, Nobori, Shuji, Vagefi, P A, Patience, C, Fishman, J, Cooper, DKC, Hawley, R J, Sachs, D H

“…The use of animal organs could potentially alleviate the critical worldwide shortage of donor organs for clinical transplantation. Because of the strong immune…”
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Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates by Hering, Bernhard J, Wijkstrom, Martin, Graham, Melanie L, Hårdstedt, Maria, Aasheim, Tor C, Jie, Tun, Ansite, Jeffrey D, Nakano, Masahiko, Cheng, Jane, Li, Wei, Moran, Kathleen, Christians, Uwe, Finnegan, Colleen, Mills, Charles D, Sutherland, David E, Bansal-Pakala, Pratima, Murtaugh, Michael P, Kirchhof, Nicole, Schuurman, Henk-Jan

“…Cell-based diabetes therapy requires an abundant cell source. Here, we report reversal of diabetes for more than 100 d in cynomolgus macaques after intraportal…”
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Current status of hepatocyte xenotransplantation by Meier, Raphael P.H, Navarro-Alvarez, Nalu, Morel, Philippe, Schuurman, Henk-Jan, Strom, Stephen, Bühler, Leo H

“…Abstract The treatment of acute liver failure, a condition with high mortality, comprises optimal clinical care, and in severe cases liver transplantation…”
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Porcine Endogenous Retrovirus Transmission Characteristics of an Inbred Herd of Miniature Swine by Oldmixon, Beth A, Wood, James C, Ericsson, Thomas A, Wilson, Carolyn A, White-Scharf, Mary E, Andersson, Goran, Greenstein, Julia L, Schuurman, Henk-Jan, Patience, Clive

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SDZ RAD, a new rapamycin derivative : Pharmacological properties in vitro and in vivo by SCHULER, W, SEDRANI, R, COTTENS, S, HÄBERLIN, B, SCHULZ, M, SCHUURMAN, H.-J, ZENKE, G, ZERWES, H.-G, SCHREIER, M. H

“…This report describes the preclinical pharmacological profile of the new rapamycin analog, SDZ RAD, i.e., 40-O-(2-hydroxyethyl)-rapamycin. The pharmacological…”
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Suppression of Natural and Elicited Antibodies in Pig‐to‐Baboon Heart Transplantation Using a Human Anti‐Human CD154 mAb‐Based Regimen by Kuwaki, Kenji, Knosalla, Christoph, Dor, Frank J. M. F., Gollackner, Bernd, Tseng, Yau‐Lin, Houser, Stuart, Mueller, Nicolas, Prabharasuth, Derek, Alt, Amy, Moran, Kathy, Cheng, Jane, Behdad, Amir, Sachs, David H., Fishman, Jay A., Schuurman, Henk‐Jan, Awwad, Michel, Cooper, David K. C.

“…Natural and elicited antipig antibodies (Abs) lead to acute humoral xenograft rejection (AHXR). Ten baboons underwent heterotopic heart transplantation (Tx)…”
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Identification of Exogenous Forms of Human-Tropic Porcine Endogenous Retrovirus in Miniature Swine by WOOD, James C, QUINN, Gary, SACHS, David H, SCHUURMAN, Henk-Jan, FISHMAN, Jay A, PATIENCE, Clive, SULING, Kristen M, OLDMIXON, Beth A, VAN TINE, Brian A, CINA, Robert, ARN, Scott, HUANG, Christine A, SCOBIE, Linda, ONIONS, David E

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Combined immersion and oral vaccination of Vietnamese catfish ( Pangasianodon hypophthalmus) confers protection against mortality caused by Edwardsiella ictaluri by Thinh, N.H., Kuo, T.Y., Hung, L.T., Loc, T.H., Chen, S.C., Evensen, Ø., Schuurman, H.J.

“…Edwardsiella ictaluri septicemia occurs worldwide and causes high mortality and considerable economic damage to the catfish industry especially in Vietnam and…”
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Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboons by Houser, Stuart L., Kuwaki, Kenji, Knosalla, Christoph, Dor, Frank J.M.F., Gollackner, Bernd, Cheng, Jane, Shimizu, Akira, Schuurman, Henk-Jan, Cooper, David K.C.

“…:  Background:  Acute humoral xenograft rejection (AHXR) is an immunologic barrier in pig‐to‐baboon organ transplantation (Tx). We report microvascular…”
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SDZ RAD, a new rapamycin derivative : Synergism with cyclosporine by SCHUURMAN, H.-J, COTTENS, S, FUCHS, S, JOERGENSEN, J, MEERLOO, T, SEDRANI, R, TANNER, M, ZENKE, G, SCHULER, W

“…SDZ RAD is a new rapamycin analog with potent immunosuppressive activity. Compounds of the rapamycin class differ in their mode of action from cyclosporine,…”
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Acute and Chronic Vascular Rejection in Nonhuman Primate Kidney Transplantation by Wieczorek, G., Bigaud, M., Menninger, K., Riesen, S., Quesniaux, V., Schuurman, H.‐J., Audet, M., Blancher, A., Mihatsch, M. J., Nickeleit, V.

“…A nonhuman primate (NHP) study was designed to evaluate in nonlife‐supporting kidney allografts the progression from acute rejection with transplant…”
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Pathology of xenograft rejection: a commentary by Schuurman, Henk-Jan, Cheng, Jane, Lam, Tuan

“…: Trends in solid organ xenograft pathology are presented, with the focus on pig‐to‐nonhuman primate models. A simplified classification of rejection is…”
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Absence of Replication-Competent Human-Tropic Porcine Endogenous Retroviruses in the Germ Line DNA of Inbred Miniature Swine by SCOBIE, Linda, TAYLOR, Samantha, WOOD, James C, SULING, Kristen M, QUINN, Gary, MEIKLE, Sharon, PATIENCE, Clive, SCHUURMAN, Henk-Jan, ONIONS, David E

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Gal alpha 1,3Gal expression on porcine pancreatic islets, testis, spleen, and thymus by Dor, F J M F, Cheng, J, Alt, A, Cooper, D K C, Schuurman, H-J

“…Gal alpha 1,3Gal (Gal) is the first target in antibody-mediated rejection of pig-to-non-human primate xenograft. Its expression may vary between organs and…”
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Reference values for clinical chemistry and clinical hematology parameters in cynomolgus monkeys by Schuurman, Henk-Jan, Smith, Harold T

“…:  Background:  In vivo xenotransplantation modeling in large animal species is often performed in nonhuman primates, including baboons. For proper data…”
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Oral efficacy of the new immunomodulator FTY720 in cynomolgus monkey kidney allotransplantation, given alone or in combination with cyclosporine or RAD by SCHUURMAN, Henk-Jan, MENNINGER, Klaus, AUDET, Maxime, KUNKLER, Adrien, MAURER, Claudine, VEDRINE, Corinne, BERNHARD, Mario, GASCHEN, Lorrie, BRINKMANN, Volker, QUESNIAUX, Valerie

“…FTY720 is a novel immunomodulator with a unique mechanism of action, i.e. chemokine-dependent lymphocyte homing into secondary lymphoid organs associated with…”
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Tolerability of cyclosphosphamide and methotrexate induction immunosuppression in nonhuman primates by Schuurman, Henk-Jan, Smith, Harold T., Cozzi, Emanuele

“…Transplantation in nonhuman primates, in particular using solid organs from porcine donors, requires an efficacious induction immunosuppression. Besides…”
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