Search Results - "Schuurkes, Jan A"

Origin and propagation of the slow wave in the canine stomach: the outlines of a gastric conduction system by Lammers, Wim J E P, Ver Donck, Luc, Stephen, Betty, Smets, Dirk, Schuurkes, Jan A J

“…Slow waves are known to originate orally in the stomach and to propagate toward the antrum, but the exact location of the pacemaker and the precise pattern of…”
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The effects of cholinergic stimulation and of nucleoside transport inhibition on spikes and spike patches in the canine small intestine in vivo by Lammers, Wim J.E.P., Donck, L. Ver, Schuurkes, Jan A.J., Smets, Dirk, Stephen, Betty

“…Muscarinic agonists are known to enhance small intestinal contractions. A similar effect was also seen in pilot experiments with a nucleoside transport…”
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Inhibition of Heat-Stable Toxin-Induced Intestinal Salt and Water Secretion by a Novel Class of Guanylyl Cyclase C Inhibitors by Bijvelds, Marcel J. C., Loos, Michaela, Bronsveld, Inez, Hellemans, Ann, Bongartz, Jean-Pierre, Donck, Luc Ver, Cox, Eric, de Jonge, Hugo R., Schuurkes, Jan A. J., De Maeyer, Joris H.

“…Background. Many enterotoxigenic Escherichia coli strains produce the heat-stable toxin, STa, which, by activation of the intestinal receptor-enzyme guanylyl…”
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Selective inhibition of intestinal guanosine 3′,5′-cyclic monophosphate signaling by small-molecule protein kinase inhibitors by Bijvelds, Marcel J.C., Tresadern, Gary, Hellemans, Ann, Smans, Karine, Nieuwenhuijze, Natascha D.A., Meijsen, Kelly F., Bongartz, Jean-Pierre, Ver Donck, Luc, de Jonge, Hugo R., Schuurkes, Jan A.J., De Maeyer, Joris H.

“…The guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) serine/threonine kinase relays signaling through guanylyl cyclase C (GCC)…”
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SSP-002392, a new 5-HT4 receptor agonist, dose-dependently reverses scopolamine-induced learning and memory impairments in C57Bl/6 mice by Lo, Adrian C., De Maeyer, Joris H., Vermaercke, Ben, Callaerts-Vegh, Zsuzsanna, Schuurkes, Jan A.J., D'Hooge, Rudi

“…5-HT4 receptors (5-HT4R) are suggested to affect learning and memory processes. Earlier studies have shown that animals treated with 5-HT4R agonists, often…”
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Focal Activities and Re-Entrant Propagations as Mechanisms of Gastric Tachyarrhythmias by Lammers, Wim J.E.P, Ver Donck, Luc, Stephen, Betty, Smets, Dirk, Schuurkes, Jan A.J

“…Background & Aims Gastric arrhythmias occur in humans and experimental animals either spontaneously or induced by drugs or diseases. However, there is no…”
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Chronic 5-HT4 receptor activation decreases Aβ production and deposition in hAPP/PS1 mice by Tesseur, Ina, Pimenova, Anna A, Lo, Adrian C, Ciesielska, Marta, Lichtenthaler, Stefan F, De Maeyer, Joris H, Schuurkes, Jan A.J, D'Hooge, Rudi, De Strooper, Bart

“…Abstract Lowering the production and accumulation of Aβ has been explored as treatment for Alzheimer's disease (AD), because Aβ is postulated to play an…”
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W1937 Initiation and Propagation of Secondary Waves in the Canine Stomach In Vivo by Lammers, Wim, Donck, Luc Ver, Stephen, Betty, Smets, Dirk, Schuurkes, Jan A

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T1794 Slow Wave Origin and Pattern of Propagation in the Canine Stomach In Vivo by Lammers, Wim, Donck, Luc Ver, Stephen, Betty, Smets, Dirk, Schuurkes, Jan A

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Peripheral pacemakers and patterns of slow wave propagation in the canine small intestine in vivo by Lammers, Wim J E P, Ver Donck, Luc, Schuurkes, Jan A J, Stephen, Betty

“…In an anesthetized, open-abdomen, canine model, the propagation pattern of the slow wave and its direction, velocity, amplitude, and frequency were…”
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Longitudinal and circumferential spike patches in the canine small intestine in vivo by Lammers, Wim J E P, Donck, Luc Ver, Schuurkes, Jan A J, Stephen, Betty

“…In an open-abdominal anesthetized and fasted canine model of the intact small intestine, the presence, location, shape, and frequency of spike patches were…”
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Contractile effects of 5‐hydroxytryptamine and 5‐carboxamidotryptamine in the equine jejunum by Delesalle, Cathérine, Deprez, Piet, Schuurkes, Jan A J, Lefebvre, Romain A

“…The use of human prokinetic drugs in colic horses leads to inconsistent results. This might be related to differences in gastrointestinal receptor populations…”
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Serotonergic modulation of murine fundic tone by Xue, Lin, Camilleri, Michael, Locke, 3rd, G Richard, Schuurkes, Jan A J, Meulemans, Ann, Coulie, Bernard J, Szurszewski, Joseph H, Farrugia, Gianrico

“…Fundic tone is maintained through a balance of excitatory and inhibitory input to fundic smooth muscle. The aim of this study was to determine the role of…”
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Differential effects of 5-hydroxytryptamine4 receptor agonists at gastric versus cardiac receptors: an operational framework to explain and quantify organ-specific behavior by De Maeyer, Joris H, Prins, Nicolaas H, Schuurkes, Jan A J, Lefebvre, Romain A

“…Quantification of different levels of 5-hydroxytryptamine4 (5-HT4) receptor agonism expression across animal species as well as across organs within the same…”
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Effect of modulation of serotonergic, cholinergic, and nitrergic pathways on murine fundic size and compliance measured by ultrasonomicrometry by Xue, Lin, Locke, G Richard, Camilleri, Michael, Schuurkes, Jan A J, Meulemans, Ann, Coulie, Bernard J, Szurszewski, Joseph H, Farrugia, Gianrico

“…Reduced fasting or postprandial gastric volumes have been implicated in the pathophysiology of functional dyspepsia. The mechanisms that underlie the control…”
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Radiosynthesis and preclinical evaluation of [11C]prucalopride as a potential agonist PET ligand for the 5-HT4 receptor by Buiter, Hans JC, Windhorst, Albert D, Huisman, Marc C, De Maeyer, Joris H, Schuurkes, Jan AJ, Lammertsma, Adriaan A, Leysen, Josée E

“…Background Serotonin 5-HT 4 receptor (5-HT 4 -R) agonists are potential therapeutic agents for enterokinetic and cognitive disorders and are marketed for…”
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Porcine left atrial and sinoatrial 5‐HT 4 receptor‐induced responses: fading of the response and influence of development by De Maeyer, Joris H, Straetemans, Roel, Schuurkes, Jan A J, Lefebvre, Romain A

“…In this study, we aimed to characterize in vitro the effects of the benzofuran 5‐HT 4 receptor agonists prucalopride, R149402 and R199715 and the indolic…”
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Inotropic effects of prokinetic agents with 5-HT4 receptor agonist actions on human isolated myocardial trabeculae by Chai, Wenxia, Chan, Kayi Y., de Vries, René, van den Bogeardt, Antoon J., de Maeyer, Joris H., Schuurkes, Jan A.J., Villalón, Carlos M., Saxena, Pramod R., Danser, A.H. Jan, MaassenVanDenBrink, Antoinette

“…Besides acting as gastrointestinal prokinetic agents, 5-hydroxytryptamine4 (5-HT4) receptor agonists can induce positive inotropism in human isolated atrium,…”
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Porcine left atrial and sinoatrial 5‐HT4 receptor‐induced responses: fading of the response and influence of development by De Maeyer, Joris H, Straetemans, Roel, Schuurkes, Jan A J, Lefebvre, Romain A

“…In this study, we aimed to characterize in vitro the effects of the benzofuran 5‐HT4 receptor agonists prucalopride, R149402 and R199715 and the indolic agents…”
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Evidence for 5‐HT 7 receptors mediating relaxation of human colonic circular smooth muscle by Prins, Nicolaas H, Briejer, Michel R, Van Bergen, Patrick J E, Akkermans, Louis M A, Schuurkes, Jan A J

“…5‐HT 4 receptors mediate relaxation of human colon circular muscle. However, after 5‐HT 4 receptor blockade (SB 204070 10 n M ), 5‐HT still induced a…”
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