Search Results - "Schutzer de Godoy, Andre"
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Amino Acid Polymorphisms on the Brazilian Strain of Yellow Fever Virus Methyltransferase Are Related to the Host's Immune Evasion Mediated by Type I Interferon
Published in Viruses (01-01-2023)“…Since late 2016, a yellow fever virus (YFV) variant carrying a set of nine amino acid variations has circulated in South America. Three of them were mapped on…”
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Discovery of an imidazonaphthyridine and a riminophenazine as potent anti-Zika virus agents through a replicon-based high-throughput screening
Published in Virus research (02-07-2021)“…•A BHK-21 cell line expressing a ZIKV Rluc replicon was developed and characterized.•400 small-molecule compounds were screened using the…”
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Imidazonaphthyridine effects on Chikungunya virus replication: Antiviral activity by dependent and independent of interferon type 1 pathways
Published in Virus research (15-01-2023)“…•RO8191 strongly inhibits CHIKV replication in cells with defective type-1 IFN production.•RO8191 inhibited multiple stages of CHIKV replication cycle.•The…”
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Expression, purification, crystallization and preliminary X-ray diffraction analysis of the pectin methylesterase from the sugar cane weevil Sphenophorus levis
Published in Acta crystallographica. Section F, Structural biology communications (01-03-2014)“…Pectin methylesterase removes the methyl groups from the main chain of pectin, the major component of the middle lamella of the plant cell wall. The enzyme is…”
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Structural and mechanistic insight from antiviral and antiparasitic enzyme drug targets for tropical infectious diseases
Published in Current opinion in structural biology (01-12-2019)“…With almost half of the world population living at risk, tropical infectious diseases cause millions of deaths every year in developing countries. Considering…”
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