Search Results - "Schutze, Nicole"

Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis by Siegemund, Sabine, Schütze, Nicole, Schulz, Silke, Wolk, Kerstin, Nasilowska, Katarzyna, Straubinger, Reinhard K., Sabat, Robert, Alber, Gottfried

“…Early activation of the IL-12/IFN-γ axis has been shown following Salmonella enterica serovar Enteritidis (S. Enteritidis) infection. We were interested to…”
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Administration of IL-23 engages innate and adaptive immune mechanisms during fungal infection by Kleinschek, Melanie A., Müller, Uwe, Schütze, Nicole, Sabat, Robert, Straubinger, Reinhard K., Blumenschein, Wendy M., McClanahan, Terrill, Kastelein, Robert A., Alber, Gottfried

“…IL-23 is a key cytokine in promotion of chronic inflammation. Here, we address if its pro-inflammatory potential can be harnessed to protect against chronic…”
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IL-13 Induces Disease-Promoting Type 2 Cytokines, Alternatively Activated Macrophages and Allergic Inflammation during Pulmonary Infection of Mice with Cryptococcus neoformans by Muller, Uwe, Stenzel, Werner, Kohler, Gabriele, Werner, Christoph, Polte, Tobias, Hansen, Gesine, Schutze, Nicole, Straubinger, Reinhard K, Blessing, Manfred, McKenzie, Andrew N. J, Brombacher, Frank, Alber, Gottfried

“…In the murine model of Cryptococcus neoformans infection Th1 (IL-12/IFN-gamma) and Th17 (IL-23/IL-17) responses are associated with protection, whereas an…”
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Immunoglobulin M-degrading enzyme of Streptococcus suis (Ide Ssuis ) impairs porcine B cell signaling by Breitfelder, Annika Katharina, Schrödl, Wieland, Rungelrath, Viktoria, Baums, Christoph Georg, Alber, Gottfried, Schütze, Nicole, Müller, Uwe

“…( ) is an important porcine pathogen, causing severe disease like meningitis and septicemia primarily in piglets. Previous work showed that the IgM-degrading…”
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Protective Immunity to Systemic Infection with Attenuated Salmonella enterica serovar Enteritidis in the Absence of IL-12 Is Associated with IL-23-Dependent IL-22, but Not IL-17 by Schulz, Silke M, Kohler, Gabriele, Schutze, Nicole, Knauer, Jens, Straubinger, Reinhard K, Chackerian, Alissa A, Witte, Ellen, Wolk, Kerstin, Sabat, Robert, Iwakura, Yoichiro, Holscher, Christoph, Muller, Uwe, Kastelein, Robert A, Alber, Gottfried

“…IL-12 is essential for protective T cell-mediated immunity against Salmonella infection. To characterize the role of the related cytokine IL-23, wild-type (WT)…”
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Immunogenicity and protective efficacy of a Streptococcus suis vaccine composed of six conserved immunogens by Weisse, Christine, Dittmar, Denise, Jakóbczak, Beata, Florian, Volker, Schütze, Nicole, Alber, Gottfried, Klose, Kristin, Michalik, Stephan, Valentin-Weigand, Peter, Völker, Uwe, Baums, Christoph Georg

“…Abstract A vaccine protecting against different Streptococcus suis serotypes is highly needed in porcine practice to improve animal welfare and reduce the use…”
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d-Alanylation of Lipoteichoic Acids in Streptococcus suis Reduces Association With Leukocytes in Porcine Blood by Öhlmann, Sophie, Krieger, Ann-Kathrin, Gisch, Nicolas, Meurer, Marita, de Buhr, Nicole, von Köckritz-Blickwede, Maren, Schütze, Nicole, Baums, Christoph Georg

“…( ) is a common swine pathogen but also poses a threat to human health in causing meningitis and severe cases of streptococcal toxic shock-like syndrome…”
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Allergen-Induced IL-6 Regulates IL-9/IL-17A Balance in CD4+ T Cells in Allergic Airway Inflammation by Schütze, Nicole, Trojandt, Stefanie, Kuhn, Stephanie, Tomm, Janina M, von Bergen, Martin, Simon, Jan C, Polte, Tobias

“…IL-9-secreting Th9 cells have been considered to play a pivotal role in the pathogenesis of atopic diseases. To what extent IL-9-producing cells are induced or…”
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Volatile organic compounds enhance allergic airway inflammation in an experimental mouse model by Bönisch, Ulrike, Böhme, Alexander, Kohajda, Tibor, Mögel, Iljana, Schütze, Nicole, von Bergen, Martin, Simon, Jan C, Lehmann, Irina, Polte, Tobias

“…Epidemiological studies suggest an association between exposure to volatile organic compounds (VOCs) and adverse allergic and respiratory symptoms. However,…”
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Critical role for syndecan-4 in dendritic cell migration during development of allergic airway inflammation by Polte, Tobias, Petzold, Susanne, Bertrand, Jessica, Schütze, Nicole, Hinz, Denise, Simon, Jan C., Lehmann, Irina, Echtermeyer, Frank, Pap, Thomas, Averbeck, Marco

“…Syndecan-4 (SDC4), expressed on dendritic cells (DCs) and activated T cells, plays a crucial role in DC motility and has been shown as a potential target for…”
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Exposure to Mycotoxins Increases the Allergic Immune Response in a Murine Asthma Model by SCHÜTZE, Nicole, LEHMANN, Irina, BÖNISCH, Ulrike, SIMON, Jan C, POLTE, Tobias

“…Epidemiological studies have shown that indoor molds are associated with increased prevalence and exacerbation of respiratory symptoms and asthma. Mycotoxins,…”
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Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: Benefits and hazards of LPS hypersensitivity by Freudenberg, Marina A, Tchaptchet, Sandrine, Keck, Simone, Fejer, György, Huber, Michael, Schütze, Nicole, Beutler, Bruce, Galanos, Chris

“…Abstract In this review, we summarize our investigations concerning the differential importance of CD14 and LBP in toll-like receptor 4 (TLR4)/myeloid…”
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Vaccination with the immunoglobulin M-degrading enzyme of Streptococcus suis, IdeSsuis, leads to protection against a highly virulent serotype 9 strain by Rieckmann, Karoline, Seydel, Anna, Klose, Kristin, Alber, Gottfried, Baums, Christoph G., Schütze, Nicole

“…•IdeSsuis vaccination of piglets significantly reduced survival of S. suis cps9 in blood.•IdeSsuis reactive T helper cells producing TNF-α, IL-17A or IFN-ɣ…”
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IgM cleavage by Streptococcus suis reduces IgM bound to the bacterial surface and is a novel complement evasion mechanism by Rungelrath, Viktoria, Weiße, Christine, Schütze, Nicole, Müller, Uwe, Meurer, Marita, Rohde, Manfred, Seele, Jana, Valentin-Weigand, Peter, Kirschfink, Michael, Beineke, Andreas, Schrödl, Wieland, Bergmann, René, Baums, Christoph Georg

“…Streptococcus suis (S. suis) causes meningitis, arthritis and endocarditis in piglets. The aim of this study was to characterize the IgM degrading enzyme of S…”
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Pathogen-Reactive T Helper Cell Analysis in the Pig by Ebner, Friederike, Schwiertz, Patrycja, Steinfelder, Svenja, Pieper, Robert, Zentek, Jürgen, Schütze, Nicole, Baums, Christoph G, Alber, Gottfried, Geldhof, Peter, Hartmann, Susanne

“…There is growing interest in studying host-pathogen interactions in human-relevant large animal models such as the pig. Despite the progress in developing…”
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Relative kinetic measurements of rate coefficients for the gas-phase reactions of Cl atoms and OH radicals with a series of methyl alkyl esters by Schütze, Nicole, Zhong, Xiaoyin, Kirschbaum, Stefan, Bejan, Iustinian, Barnes, Ian, Benter, Thorsten

“…Relative kinetic studies have been performed on the reactions of Cl atoms with a series of methyl alkyl esters in a 405-liter borosilicate glass chamber at…”
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Analysis of Porcine Pro- and Anti-Inflammatory Cytokine Induction by S. suis In Vivo and In Vitro by Hohnstein, Florian S, Meurer, Marita, de Buhr, Nicole, von Köckritz-Blickwede, Maren, Baums, Christoph G, Alber, Gottfried, Schütze, Nicole

“…Weaning piglets are susceptible to the invasive infection, which can result in septicemia. The aim of this study was to investigate the cytokine profile…”
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Generation of IL-8 and IL-9 Producing CD4^+ T Cells Is Affected by Th17 Polarizing Conditions and AHR Ligands by Gasch, Michaela, Goroll, Tina, Bauer, Mario, Hinz, Denise, Schütze, Nicole, Polte, Tobias, Kesper, Dörthe, Simon, Jan C., Hackermüller, Jörg, Lehmann, Irina, Herberth, Gunda

“…The T helper cell subsets Th1, Th2, Th17, and Treg play an important role in immune cell homeostasis, in host defense, and in immunological disorders…”
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IL-12p40-Dependent Agonistic Effects on the Development of Protective Innate and Adaptive Immunity Against Salmonella Enteritidis by Lehmann, Jorg, Bellmann, Steffi, Werner, Christoph, Schroder, Regina, Schutze, Nicole, Alber, Gottfried

“…To study a potential IL-12p40-dependent but IL-12p75-independent agonistic activity regulating the immune response against Salmonella Enteritidis, the course…”
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Production of IL-12, IL-23 and IL-27p28 by bone marrow-derived conventional dendritic cells rather than macrophages after LPS/TLR4-dependent induction by Salmonella Enteritidis by Siegemund, Sabine, Schütze, Nicole, Freudenberg, Marina A, Lutz, Manfred B, Straubinger, Reinhard K, Alber, Gottfried

“…Abstract Induction of the interleukin-12 (IL-12) cytokine family comprising IL-12, IL-23, IL-27, and IL-12p40 by intracellular pathogens is required for…”
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