Search Results - "Schutt, Leah K"

GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer by Liang, Jun, Zbieg, Jason R., Blake, Robert A., Chang, Jae H., Daly, Stephen, DiPasquale, Antonio G., Friedman, Lori S., Gelzleichter, Thomas, Gill, Matthew, Giltnane, Jennifer M., Goodacre, Simon, Guan, Jane, Hartman, Steven J., Ingalla, Ellen Rei, Kategaya, Lorn, Kiefer, James R., Kleinheinz, Tracy, Labadie, Sharada S., Lai, Tommy, Li, Jun, Liao, Jiangpeng, Liu, Zhiguo, Mody, Vidhi, McLean, Neville, Metcalfe, Ciara, Nannini, Michelle A., Oeh, Jason, O’Rourke, Martin G., Ortwine, Daniel F., Ran, Yingqing, Ray, Nicholas C., Roussel, Fabien, Sambrone, Amy, Sampath, Deepak, Schutt, Leah K., Vinogradova, Maia, Wai, John, Wang, Tao, Wertz, Ingrid E., White, Jonathan R., Yeap, Siew Kuen, Young, Amy, Zhang, Birong, Zheng, Xiaoping, Zhou, Wei, Zhong, Yu, Wang, Xiaojing

Get full text

Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors by Hu, Dennis X., Patel, Snahel, Chen, Huifen, Wang, Shumei, Staben, Steven T., Dimitrova, Yoana N., Wallweber, Heidi Ackerly, Lee, Joanna Y., Chan, Grace Ka Yan, Sneeringer, Christopher J., Prangley, Madeleine S., Moffat, John G., Wu, Kai C., Schutt, Leah K., Salphati, Laurent, Pang, Jodie, McNamara, Erin, Huang, Haochu, Chen, Yong, Wang, Yunli, Zhao, Wensheng, Lim, Junghyun, Murthy, Aditya, Siu, Michael

“…VPS34 is a class III phosphoinositide 3-kinase involved in endosomal trafficking and autophagosome formation. Inhibitors of VPS34 were believed to have value…”
Get full text

Target arm affinities determine preclinical efficacy and safety of anti-HER2/CD3 bispecific antibody by Staflin, Karin, Zuch de Zafra, Christina L, Schutt, Leah K, Clark, Vanessa, Zhong, Fiona, Hristopoulos, Maria, Clark, Robyn, Li, Ji, Mathieu, Mary, Chen, Xiaocheng, Johnston, Jennifer, Low, Justin, Ybarra, Ryan, Slaga, Dionysos, Yang, Jihong, Ovacik, Meric, Dybdal, Noël O, Totpal, Klara, Junttila, Melissa R, Ellerman, Diego, Lee, Genee, Dennis, Mark S, Prell, Rodney, Junttila, Teemu T

“…Systemic cytokine release and on-target/off-tumor toxicity to normal tissues are the main adverse effects limiting the clinical utility of T cell-redirecting…”
Get full text

Bruton's Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in Rats by Erickson, Rebecca I, Schutt, Leah K, Tarrant, Jacqueline M, McDowell, Michelle, Liu, Lichuan, Johnson, Adam R, Lewin-Koh, Sock-Cheng, Hedehus, Maj, Ross, Jed, Carano, Richard A D, Staflin, Karin, Zhong, Fiona, Crawford, James J, Zhong, Shelly, Reif, Karin, Katewa, Arna, Wong, Harvey, Young, Wendy B, Dambach, Donna M, Misner, Dinah L

“…Bruton's tyrosine kinase (BTK) is a member of the Tec family of cytoplasmic tyrosine kinases involved in B-cell and myeloid cell signaling. Small molecule…”
Get more information

Cystic ectopic lingual thyroid tissue in a male cat by Reed, Travis P, Brisson, Brigitte A, Schutt, Leah K

“…Case Description—A 6-year-old neutered male cat was examined because of a 4-week history of abnormal sounds while drinking and a previously noted mass at the…”
Get full text

Microchip-Associated Sarcoma in a Shrew (Suncus murinus) by Schutt, Leah K, Turner, Patricia V

“…A 16-mo-old female house musk shrew (Suncus murinus) with a 1-wk history of a rapidly growing subcutaneous mass in the interscapsular region was euthanized and…”
Get full text