Search Results - "Schutsky, Keith"

The Impact of Chemotherapy, Radiation and Epigenetic Modifiers in Cancer Cell Expression of Immune Inhibitory and Stimulatory Molecules and Anti-Tumor Efficacy by Chacon, Jessica Ann, Schutsky, Keith, Powell, Daniel J

“…Genomic destabilizers, such as radiation and chemotherapy, and epigenetic modifiers are used for the treatment of cancer due to their apoptotic effects on the…”
Get full text

Limited brain metabolism changes differentiate between the progression and clearance of rabies virus by Schutsky, Keith, Portocarrero, Carla, Hooper, D Craig, Dietzschold, Bernhard, Faber, Milosz

“…Central nervous system (CNS) metabolic profiles were examined from rabies virus (RABV)-infected mice that were either mock-treated or received post-exposure…”
Get full text

Intramuscular Inoculation of Mice with the Live-Attenuated Recombinant Rabies Virus TriGAS Results in a Transient Infection of the Draining Lymph Nodes and a Robust, Long-Lasting Protective Immune Response against Rabies by Schutsky, Keith, Curtis, Dana, Bongiorno, Emily K, Barkhouse, Darryll A, Kean, Rhonda B, Dietzschold, Bernhard, Hooper, D Craig, Faber, Milosz

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Redundant catecholamine signaling consolidates fear memory via phospholipase C by Ouyang, Ming, Young, Matthew B, Lestini, Melissa M, Schutsky, Keith, Thomas, Steven A

“…Memories for emotionally arousing experiences are typically vivid and persistent. The recurrent, intrusive memories of traumatic events in post-traumatic…”
Get full text

Low-Dose Radioimmunotherapy (90Y-PAM4) Combined with Gemcitabine for the Treatment of Experimental Pancreatic Cancer by David V. Gold, Keith Schutsky, David Modrak, Thomas M. Cardillo

“…Purpose: Monoclonal antibody PAM4 is reactive with the MUC1 mucin as expressed by >85% of human pancreatic cancers. Significant antitumor effects have been…”
Get full text

Feasibility and Safety of RNA-transfected CD20-specific Chimeric Antigen Receptor T Cells in Dogs with Spontaneous B Cell Lymphoma by Panjwani, M Kazim, Smith, Jenessa B, Schutsky, Keith, Gnanandarajah, Josephine, O'Connor, Colleen M, Powell, Daniel J, Mason, Nicola J

“…Preclinical murine models of chimeric antigen receptor (CAR) T cell therapy are widely applied, but are greatly limited by their inability to model the complex…”
Get full text

Stress and Glucocorticoids Impair Memory Retrieval via β 2 -Adrenergic, G i/o -Coupled Suppression of cAMP Signaling by Schutsky, Keith, Ouyang, Ming, Castelino, Christina B., Zhang, Lei, Thomas, Steven A.

“…Acute stress impairs the retrieval of hippocampus-dependent memory, and this effect is mimicked by exogenous administration of stress-responsive glucocorticoid…”
Get full text

Xamoterol impairs hippocampus-dependent emotional memory retrieval via Gi/o-coupled β2-adrenergic signaling by Schutsky, Keith, Ouyang, Ming, Thomas, Steven A

“…Xamoterol, a partial β(1)-adrenergic receptor agonist, has been reported to impair the retrieval of hippocampus-dependent spatial reference memory in rats. In…”
Get full text

Rigorous optimization and validation of potent RNA CAR T cell therapy for the treatment of common epithelial cancers expressing folate receptor by Schutsky, Keith, Song, D Gang, Lynn, Rachel, Smith, Jenessa B, Poussin, Mathilde, Figini, Mariangela, Zhao, Yangbing, Powell, Jr, Daniel J

“…Using lentiviral technology, we recently demonstrated that incorporation of CD27 costimulation into CARs greatly improves antitumor activity and T cell…”
Get full text

Immune memory in the CNS (P1177) by Garcia, Samantha, Portocarrero, Carla, Kean, Rhonda, Schutsky, Keith, Hooper, Douglas

“…Abstract Due to specialized neurovasculature, referred to as the blood-brain barrier (BBB), CNS tissues are immunologically privileged and only infiltrated by…”
Get full text

Enhanced delivery of antibodies across the blood-brain barrier via TEMs with inherent receptor-mediated phagocytosis by Edavettal, Suzanne, Cejudo-Martin, Pilar, Dasgupta, Bidisha, Yang, Danlin, Buschman, Matthew D, Domingo, Derrick, Van Kolen, Kristof, Jaiprasat, Pharavee, Gordon, Renata, Schutsky, Keith, Geist, Brian, Taylor, Natalie, Soubrane, Camille Helene, Van Der Helm, Elisabeth, LaCombe, Ann, Ainekulu, Zemeda, Lacy, Eilyn, Aligo, Jason, Ho, Jason, He, Yingbo, Lebowitz, Peter F, Patterson, James T, Scheer, Justin M, Singh, Sanjaya

“…The near impermeability of the blood-brain barrier (BBB) and the unique neuroimmune environment of the CNS prevents the effective use of antibodies in…”
Get more information

High affinity FRβ-specific CAR T cells eradicate AML and normal yeloid lineage without HSC toxicity by Lynn, Rachel C, Feng, Yang, Schutsky, Keith, Poussin, Mathilde, Kalota, Anna, Dimitrov, Dimiter S, Powell, Daniel J

“…Acute myeloid leukemia (AML) is an aggressive malignancy, and development of new treatments to prolong remissions is warranted. Chimeric antigen receptor (CAR)…”
Get full text

Xamoterol impairs hippocampus-dependent emotional memory retrieval via G i/o -coupled β 2 -adrenergic signaling by Schutsky, Keith, Ouyang, Ming, Thomas, Steven A.

“…Xamoterol, a partial β 1 -adrenergic receptor agonist, has been reported to impair the retrieval of hippocampus-dependent spatial reference memory in rats. In…”
Get full text

285. Exploring On-Target Hematopoietic Toxicity With Highly Potent, High Affinity FRβ-Specific CAR T Cells for AML by Lynn, Rachel C., Poussin, Mathilde, Feng, Yang, Schutsky, Keith, Kalota, Anna, Low, Philip S., Dimitrov, Dimiter S., Powell, Daniel J.

Get full text

Xamoterol impairs hippocampus-dependent emotional memory retrieval via Gi/o-coupled beta 2-adrenergic signaling by Schutsky, Keith, Ouyang, Ming, Thomas, Steven A

“…Xamoterol, a partial beta 1-adrenergic receptor agonist, has been reported to impair the retrieval of hippocampus-dependent spatial reference memory in rats…”
Get full text

Abstract ND07: JNJ-78306358: A first-in-class bispecific T cell redirecting HLA-G antibody by Obermajer, Nataša, Zwolak, Adam, Van De Ven, Kelly, Versmissen, Shana, Brajic, Aleksandra, Petley, Ted, Weinstock, Dan, Aligo, Jason, Yi, Fang, Jarantow, Stephen, Schutsky, Keith, Tian, Ken, Lorraine, Angelilo, Arias, Diana Alvarez, Buyens, Kristel, Torti, Vince, Menard, Krista, Rogers, Katharine, Geist, Brian, Van Heerden, Marjolein, Chu, Gerald, Verbist, Bie, Ongenaert, Maté, Hasler, Julien, Packman, Kathryn, Shenton, Jacintha, Brehmer, Dirk, Lauring, Josh, Brown, Regina J., Greger, James, Ryan, Daphne Salick, Singh, Sanjaya, Lorenzi, Matthew V., Lenox, Laurie, Laquerre, Sylvie

“…Abstract JNJ-78306358 is a first-in-class bispecific antibody (bsAb), engineered using the Zymeworks Azymetric™ platform, to treat advanced stage solid tumors…”
Get full text

NOREPINEPHRINE AND β1-ADRENERGIC SIGNALING FACILITATE ACTIVATION OF HIPPOCAMPAL CA1 PYRAMIDAL NEURONS DURING CONTEXTUAL MEMORY RETRIEVAL by Murchison, Charles F., Schutsky, Keith, Jin, Sung-Ha, Thomas, Steven A.

“…We previously described a role for adrenergic signaling in the hippocampus to promote contextual and spatial memory retrieval. A subsequent study performing…”
Get full text

Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling by Schutsky, Keith, Ouyang, Ming, Castelino, Christina B, Zhang, Lei, Thomas, Steven A

“…Acute stress impairs the retrieval of hippocampus-dependent memory, and this effect is mimicked by exogenous administration of stress-responsive glucocorticoid…”
Get full text

Feasibility and safety of cCD20 RNA CAR-bearing T cell therapy for the treatment of canine B cell malignancies by Smith, Jenessa B, Panjwani, M Kazim, Schutsky, Keith, Gnanandarajah, Josephine, Calhoun, Sondra, Cooper, Laurence, Mason, Nicola, Powell, Daniel J

“…CD19 chimeric antigen receptor (CAR) T cell therapy has shown great promise in treating human hematological malignancies. However, the full potential of CAR…”
Get full text

The role of stress, glucocorticoids & β-adrenergic signaling in aversive, hippocampus-dependent memory retrieval by Schutsky, Keith

“…Studies in wild-type rats and mice, and mutant mice lacking norepinephrine (NE) demonstrate that NE, β1-adrenergic, cAMP/PKA and Epac signaling are required…”
Get full text