Search Results - "Schutsky, K"

High-affinity FRβ-specific CAR T cells eradicate AML and normal myeloid lineage without HSC toxicity by Lynn, R C, Feng, Y, Schutsky, K, Poussin, M, Kalota, A, Dimitrov, D S, Powell Jr, D J

“…Acute myeloid leukemia (AML) is an aggressive malignancy, and development of new treatments to prolong remissions is warranted. Chimeric antigen receptor (CAR)…”
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Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase by Schutsky, Emily K, DeNizio, Jamie E, Hu, Peng, Liu, Monica Yun, Nabel, Christopher S, Fabyanic, Emily B, Hwang, Young, Bushman, Frederic D, Wu, Hao, Kohli, Rahul M

“…A bisulfite-free sequencing method yields high-confidence 5hmC profiles in low-input samples. Here we present APOBEC-coupled epigenetic sequencing (ACE-seq), a…”
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Norepinephrine and ß1 -adrenergic signaling facilitate activation of hippocampal CA1 pyramidal neurons during contextual memory retrieval by Murchison, C.F, Schutsky, K, Jin, S.-H, Thomas, S.A

“…Abstract We previously described a role for adrenergic signaling in the hippocampus to promote contextual and spatial memory retrieval. A subsequent study…”
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APOBEC3A efficiently deaminates methylated, but not TET-oxidized, cytosine bases in DNA by Schutsky, Emily K, Nabel, Christopher S, Davis, Amy K F, DeNizio, Jamie E, Kohli, Rahul M

“…AID/APOBEC family enzymes are best known for deaminating cytosine bases to uracil in single-stranded DNA, with characteristic sequence preferences that can…”
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The Structure of Human GALNS Reveals the Molecular Basis for Mucopolysaccharidosis IV A by Rivera-Colón, Yadilette, Schutsky, Emily K., Kita, Adriana Z., Garman, Scott C.

“…Lysosomal enzymes catalyze the breakdown of macromolecules in the cell. In humans, loss of activity of a lysosomal enzyme leads to an inherited metabolic…”
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Direct enzymatic sequencing of 5-methylcytosine at single-base resolution by Wang, Tong, Fowler, Johanna M., Liu, Laura, Loo, Christian E., Luo, Meiqi, Schutsky, Emily K., Berríos, Kiara N., DeNizio, Jamie E., Dvorak, Ashley, Downey, Nick, Montermoso, Saira, Pingul, Bianca Y., Nasrallah, MacLean, Gosal, Walraj S., Wu, Hao, Kohli, Rahul M.

“…5-methylcytosine (5mC) is the most important DNA modification in mammalian genomes. The ideal method for 5mC localization would be both nondestructive of DNA…”
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Bisulfite-Free Sequencing of 5-Hydroxymethylcytosine with APOBEC-Coupled Epigenetic Sequencing (ACE-Seq) by Wang, Tong, Luo, Meiqi, Berrios, Kiara N, Schutsky, Emily K, Wu, Hao, Kohli, Rahul M

“…Here, we provide a detailed protocol for our previously published technique, APOBEC-Coupled Epigenetic Sequencing (ACE-Seq), which localizes…”
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The Base-Editing Enzyme APOBEC3A Catalyzes Cytosine Deamination in RNA with Low Proficiency and High Selectivity by Barka, Aleksia, Berríos, Kiara N, Bailer, Peter, Schutsky, Emily K, Wang, Tong, Kohli, Rahul M

“…Human APOBEC3A (A3A) is a nucleic acid-modifying enzyme that belongs to the cytidine deaminase family. Canonically, A3A catalyzes the deamination of cytosine…”
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Harnessing natural DNA modifying activities for editing of the genome and epigenome by DeNizio, Jamie E, Schutsky, Emily K, Berrios, Kiara N, Liu, Monica Yun, Kohli, Rahul M

“…[Display omitted] •Site-specific genome and epigenome editing are rapidly advancing.•Knowledge of DNA-modifying enzymes can be exploited to improve…”
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The expanding scope and impact of epigenetic cytosine modifications by Liu, Monica Yun, DeNizio, Jamie E, Schutsky, Emily K, Kohli, Rahul M

“…[Display omitted] •We review the chemical biology of epigenetic cytosine modifications.•TET enzymes expand the epigenome by sequentially oxidizing…”
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Mechanisms for targeted, purposeful mutation revealed in an APOBEC–DNA complex by Schutsky, Emily K, Hostetler, Zachary M, Kohli, Rahul M

“…Targeted deamination of cytosine bases in DNA by AID/APOBEC-family enzymes is critical for proper immune function, but it also poses risks to genomic…”
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Molecular targeting of mutagenic AID and APOBEC deaminases by Nabel, Christopher S, Schutsky, Emily K, Kohli, Rahul M

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Norepinephrine and ß 1-adrenergic signaling facilitate activation of hippocampal CA1 pyramidal neurons during contextual memory retrieval by Murchison, C.F., Schutsky, K., Jin, S.-H., Thomas, S.A.

“…We previously described a role for adrenergic signaling in the hippocampus to promote contextual and spatial memory retrieval. A subsequent study performing…”
Get full text

High-affinity FR[beta]-specific CAR T cells eradicate AML and normal myeloid lineage without HSC toxicity by Lynn, R C, Feng, Y, Schutsky, K, Poussin, M, Kalota, A, Dimitrov, D S, Powell Jr, D J

“…Acute myeloid leukemia (AML) is an aggressive malignancy, and development of new treatments to prolong remissions is warranted. Chimeric antigen receptor (CAR)…”
Get full text

Norepinephrine and A1-adrenergic signaling facilitate activation of hippocampal CA1 pyramidal neurons during contextual memory retrieval by Murchison, C F, Schutsky, K, Jin, S-H, Thomas, SA

“…We previously described a role for adrenergic signaling in the hippocampus to promote contextual and spatial memory retrieval. A subsequent study performing…”
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Low-Dose Radioimmunotherapy (90Y-PAM4) Combined with Gemcitabine for the Treatment of Experimental Pancreatic Cancer by David V. Gold, Keith Schutsky, David Modrak, Thomas M. Cardillo

“…Purpose: Monoclonal antibody PAM4 is reactive with the MUC1 mucin as expressed by >85% of human pancreatic cancers. Significant antitumor effects have been…”
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Crystal Structure of N-Acetylgalactosamine-6-Sulfatase: The Molecular Basis for Mucopolysaccharidosis Iva by Rivera-Colon, Yadilette, Schutsky, Emily K., Garman, Scott C.

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Combined super(90)Yttrium-DOTA-labeled PAM4 antibody radioimmunotherapy and gemcitabine radiosensitization for the treatment of a human pancreatic cancer xenograft by Gold, D V, Modrak, DE, Schutsky, K, Cardillo, T M

“…We have examined the application of super(90)Y-DOTA-cPAM4, anti-MUC1 IgG, in combination with the front-line drug gemcitabine as a potential therapeutic for…”
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Defining and Exploiting the Cytosine Deaminase Activity of APOBEC3A on the Extended Epigenome by Schutsky, Emily K

“…AID/APOBEC family cytosine deaminases canonically play crucial roles in immunity by converting cytosine to uracil in single-stranded DNA (ssDNA). Outside of…”
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Crystal structure of N-acetylgalactosamine-6-sulfatase: The molecular basis for Mucopolysaccharidosis IVA by Rivera-Colon, Yadilette, Schutsky, Emily K., Garman, Scott C.

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