Search Results - "Schutgens, REG"

The Perspectives of Adolescents and Young Adults on Adherence to Prophylaxis in Hemophilia: A Qualitative Study by Hoefnagels, J W, Kars, M C, Fischer, K, Schutgens, Reg, Schrijvers, L H

“…Adolescents and young adults (AYAs) with severe hemophilia use prophylaxis that requires a high level of adherence. The present study aimed to explore the…”
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How I treat age-related morbidities in elderly persons with hemophilia by Mannucci, Pier M., Schutgens, Roger E.G., Santagostino, Elena, Mauser-Bunschoten, Evelien P.

“…In persons with hemophilia, life expectancy is now approaching that of the general male population, at least in countries that can afford regular replacement…”
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Cardiovascular disease in patients with hemophilia by TUINENBURG, A., MAUSER‐BUNSCHOTEN, E. P., VERHAAR, M. C., BIESMA, D. H., SCHUTGENS, R. E. G.

“…Mortality due to ischemic heart disease in hemophilia patients is lower as compared to the general male population. Differences in the prevalence of…”
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Long-term effects of joint bleeding before starting prophylaxis in severe haemophilia by Nijdam, A., Foppen, W., van der Schouw, Y. T., Mauser-Bunschoten, E. P., Schutgens, R. E. G., Fischer, K.

“…Introduction Early initiation of prophylaxis in severe haemophilia is critical for effective prevention of arthropathy. However, the optimum time for starting…”
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Antithrombotic Treatment in Patients With Hemophilia: an EHA‐ISTH‐EAHAD‐ESO Clinical Practice Guidance by Schutgens, Roger E.G., Jimenez‐Yuste, Victor, Escobar, Miguel, Falanga, Anna, Gigante, Bruna, Klamroth, Robert, Lassila, Riitta, Leebeek, Frank W.G., Makris, Michael, Owaidah, Tarek, Sholzberg, Michelle, Tiede, Andreas, Werring, David J., Worp, H. Bart, Windyga, Jerzy, Castaman, Giancarlo

“…Cardiovascular disease is an emerging medical issue in patients with hemophilia (PWH) and its prevalence is increasing up to 15% in PWH in the United States…”
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Co-morbidity in the ageing haemophilia patient: the down side of increased life expectancy by MAUSER-BUNSCHOTEN, E. P., FRANSEN VAN DE PUTTE, D. E., SCHUTGENS, R. E. G.

“…Because of an increased life expectancy, (age‐related) co‐morbidity is becoming a common occurrence in haemophilia patients. In this review,…”
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Is pharmacokinetic-guided dosing of desmopressin and von Willebrand factor-containing concentrates in individuals with von Willebrand disease or low von Willebrand factor reliable and feasible? A protocol for a multicentre, non-randomised, open label cohort trial, the OPTI-CLOT: to WiN study by Heijdra, Jessica M, Al Arashi, Wala, de Jager, Nico C B, Cloesmeijer, Michael E, Bukkems, Laura H, Zwaan, Christian M, Leebeek, Frank W G, Mathôt, Ron A A, Cnossen, Marjon H, Cnossen, MH, Leebeek, FWG, Fijnvandraat, K, Mathôt, RAA, Meijer, K, Kruip, MJHA, Polinder, S, Coppens, M, Tamminga, RYJ, Laros-van Gorkom, BAP, Brons, P, Schols, SEM, van der Meer, FJM, Eikenboom, HCJ, Schutgens, REG, Fischer, K, Heubel-Moenen, F, Nieuwenhuizen, L, Ypma, P, Driessens, MHE, Zwaan, CM, van Vliet, I, Collins, PW, Liesner, R, Chowdary, P, Keeling, D, Lock, J, Hazendonk, HCAM, van Moort, I, Preijers, T, Heijdra, JM, de Jager, NCB, Goedhart, MCHJ, Bukkems, LH, Al Arashi, W, Cloesmeijer, ME, Janssen, A

“…IntroductionVon Willebrand disease (VWD) is a bleeding disorder, caused by a deficiency or defect of von Willebrand factor (VWF). In case of medical procedures…”
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First preclinical support for the 'danger theory' in inhibitor development by van Vulpen, L. F. D., Mastbergen, S. C., Schutgens, R. E. G.

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Continuous infusion of recombinant factor VIII formulated with sucrose in surgery: Non-interventional, observational study in patients with severe haemophilia A by Meijer, K., Rauchensteiner, S., Santagostino, E., Platokouki, H., Schutgens, R. E. G., Brunn, M., Tueckmantel, C., Valeri, F., Schinco, P. C.

“…Summary In haemophilia A, continuous infusion (CI) of FVIII perioperatively provides a more constant FVIII level than conventional bolus injections, avoiding…”
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Silencing of protease-activated receptors attenuates synovitis and cartilage damage following a joint bleed in haemophilic mice by Nieuwenhuizen, L., Schutgens, R. E. G., Coeleveld, K., Mastbergen, S. C., Schiffelers, R. M., Roosendaal, G., Biesma, D. H., Lafeber, F. P. J. G.

“…Introduction and aim Joint bleeding results in blood‐induced arthropathy. We investigate whether a joint bleed alters protease‐activated receptor (PAR)…”
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Obesity in haemophilia patients: effect on bleeding frequency, clotting factor concentrate usage, and haemostatic and fibrinolytic parameters by Tuinenburg, A., Biere-Rafi, S., Peters, M., Verhamme, P., Peerlinck, K., Kruip, M. J. H. A., Laros-Van Gorkom, B. A. P., Roest, M., Meijers, J. C. M., Kamphuisen, P. W., Schutgens, R. E. G.

“…Summary The prevalence of obesity in patients with haemophilia (PWH) is increasing. We investigated the effect of obesity on bleeding frequency and clotting…”
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Combination of a normal D-dimer concentration and a non-high pretest clinical probability score is a safe strategy to exclude deep venous thrombosis by SCHUTGENS, R. E. G, ACKERMARK, P, HAAS, F. J. L. M, NIEUWENHUIS, H. K, PELTENBURG, H. G, PIJLMAN, A. H, PRUIJM, M, OLTMANS, R, KELDER, J. C, BIESMA, D. H

“…Serial ultrasonography is reliable for the diagnosis of deep venous thrombosis in symptomatic patients, but the low prevalence of thrombosis in this group…”
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Stimulation of Naïve Monocytes and PBMCs with Coagulation Proteases Results in Thrombin‐Mediated and PAR‐1‐Dependent Cytokine Release and Cell Proliferation in PBMCs Only by Nieuwenhuizen, L., Falkenburg, W. J. J., Schutgens, R. E. G., Roosendaal, G., Veghel, K., Biesma, D. H., Lafeber, F. P. J. G.

“…Protease‐activated receptors (PARs) are stimulated by proteolytic cleavage of their extracellular domain. Coagulation proteases, such as FVIIa, the binary…”
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Challenges and controversies in haemophilia care in adulthood by DOLAN, G., HERMANS, C., KLAMROTH, R., MADHOK, R., SCHUTGENS, R. E. G., SPENGLER, U.

“…Overall life expectancy and quality of life among persons with haemophilia have increased in recent years, primarily because of the advances in factor…”
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Reduced efficacy of clinical probability score and d‐dimer assay in elderly subjects suspected of having deep vein thrombosis by Schutgens, Roger E. G., Haas, Fred J. L. M., Biesma, Douwe H.

“…Summary The combined strategy of a pretest clinical probability (PCP) score and d‐dimer has shown to be of value in the diagnosis of deep vein thrombosis…”
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The predictive value of D-dimer measurement for cancer in patients with deep vein thrombosis by Schutgens, RE, Beckers, MM, Haas, FJ, Biesma, DH

“…Department of Hematology, University Hospital Utrecht, the Netherlands. schutgensvos@hetnet.nl BACKGROUND AND OBJECTIVES: Venous thromboembolism can be related…”
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The usefulness of five d‐dimer assays in the exclusion of deep venous thrombosis by Schutgens, R. E. G., Haas, F. J. L. M., Gerritsen, W. B. M., Van Der Horst, F., Nieuwenhuis, H. K., Biesma, D. H.

“…d‐Dimer measurement is a promising tool in the exclusion of venous thrombosis. New d‐dimer assays have been introduced, but need clinical validation. Our…”
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Usefulness of a semiquantitative D-dimer test for the exclusion of deep venous thrombosis in outpatients by Schutgens, Roger E G, Esseboom, Earl U, Haas, Fred J L M, Nieuwenhuis, H Karel, Biesma, Douwe H

“…The D-dimer test is used commonly in diagnostic strategies to reduce the need for ultrasonography in patients suspected of having deep venous thrombosis. We…”
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No influence of heparin plasma and other (pre)analytic variables on D-dimer determinations by SCHUTGENS, Roger E. G, HAAS, Fred J. L. M, RUVEN, Henk J. T, SPANNAGL, Michael, HORN, Klaus, BIESMA, Douwe H

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The early course of D-dimer concentration following pulmonary artery embolisation by Mager, J J, Schutgens, R E, Haas, F J, Westermann, C J, Biesma, D H

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