Search Results - "Schuster, Iona"

ILC1 Confer Early Host Protection at Initial Sites of Viral Infection by Weizman, Orr-El, Adams, Nicholas M., Schuster, Iona S., Krishna, Chirag, Pritykin, Yuri, Lau, Colleen, Degli-Esposti, Mariapia A., Leslie, Christina S., Sun, Joseph C., O’Sullivan, Timothy E.

“…Infection is restrained by the concerted activation of tissue-resident and circulating immune cells. Whether tissue-resident lymphocytes confer early antiviral…”
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TRAIL+ NK Cells Control CD4+ T Cell Responses during Chronic Viral Infection to Limit Autoimmunity by Schuster, Iona S., Wikstrom, Matthew E., Brizard, Geraldine, Coudert, Jerome D., Estcourt, Marie J., Manzur, Mitali, O’Reilly, Lorraine A., Smyth, Mark J., Trapani, Joseph A., Hill, Geoffrey R., Andoniou, Christopher E., Degli-Esposti, Mariapia A.

“…Natural killer (NK) cells have been reported to control adaptive immune responses that occur in lymphoid organs at the early stages of immune challenge…”
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MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota by Koyama, Motoko, Mukhopadhyay, Pamela, Schuster, Iona S., Henden, Andrea S., Hülsdünker, Jan, Varelias, Antiopi, Vetizou, Marie, Kuns, Rachel D., Robb, Renee J., Zhang, Ping, Blazar, Bruce R., Thomas, Ranjeny, Begun, Jakob, Waddell, Nicola, Trinchieri, Giorgio, Zeiser, Robert, Clouston, Andrew D., Degli-Esposti, Mariapia A., Hill, Geoffrey R.

“…Graft-versus-host disease (GVHD) in the gastrointestinal (GI) tract is the principal determinant of lethality following allogeneic bone marrow transplantation…”
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Tissue‐resident memory NK cells: Homing in on local effectors and regulators by Schuster, Iona S., Andoniou, Christopher E., Degli‐Esposti, Mariapia A.

“…Summary Natural killer (NK) cells are the prototype innate effector lymphocyte population that plays an important role in controlling viral infections and…”
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"Natural Regulators": NK Cells as Modulators of T Cell Immunity by Schuster, Iona S, Coudert, Jerome D, Andoniou, Christopher E, Degli-Esposti, Mariapia A

“…Natural killer (NK) cells are known as frontline responders capable of rapidly mediating a response upon encountering transformed or infected cells. Recent…”
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Strain-specific antibody therapy prevents cytomegalovirus reactivation after transplantation by Martins, Jose Paulo, Andoniou, Christopher E, Fleming, Peter, Kuns, Rachel D, Schuster, Iona S, Voigt, Valentina, Daly, Sheridan, Varelias, Antiopi, Tey, Siok-Keen, Degli-Esposti, Mariapia A, Hill, Geoffrey R

“…Cytomegalovirus infection is a frequent and life-threatening complication that significantly limits positive transplantation outcomes. We developed preclinical…”
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Dietary Fiber and Microbiota Metabolite Receptors Enhance Cognition and Alleviate Disease in the 5xFAD Mouse Model of Alzheimer's Disease by Zhou, Yichen, Xie, Liang, Schröder, Jan, Schuster, Iona S, Nakai, Michael, Sun, Guizhi, Sun, Yu B Y, Mariño, Eliana, Degli-Esposti, Mariapia A, Marques, Francine Z, Grubman, Alexandra, Polo, Jose M, Mackay, Charles R

“…Alzheimer's disease (AD) is a neurodegenerative disorder with poorly understood etiology. AD has several similarities with other "Western lifestyle"…”
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NKG7 – regulating endosomal pathways? by Schuster, Iona S, Andoniou, Christopher E

“…Ng et al. have identified NKG7 as a regulator of inflammation in response to diverse immunological challenges. While NKG7 was required for the degranulation of…”
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DOT1L maintains NK cell phenotype and function for optimal tumor control by Sudholz, Harrison, Schuster, Iona S., Foroutan, Momeneh, Sng, Xavier, Andoniou, Christopher E., Doan, Anh, Camilleri, Tania, Shen, Zihan, Zaph, Colby, Degli-Esposti, Mariapia A., Huntington, Nicholas D., Scheer, Sebastian

“…Histone methyltransferases (HMTs) are crucial in gene regulation and function, yet their role in natural killer (NK) cell biology within the tumor…”
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Infection induces tissue-resident memory NK cells that safeguard tissue health by Schuster, Iona S., Sng, Xavier Y.X., Lau, Colleen M., Powell, David R., Weizman, Orr-El, Fleming, Peter, Neate, Georgia E.G., Voigt, Valentina, Sheppard, Sam, Maraskovsky, Andreas I., Daly, Sheridan, Koyama, Motoko, Hill, Geoffrey R., Turner, Stephen J., O’Sullivan, Timothy E., Sun, Joseph C., Andoniou, Christopher E., Degli-Esposti, Mariapia A.

“…Tissue health is dictated by the capacity to respond to perturbations and then return to homeostasis. Mechanisms that initiate, maintain, and regulate immune…”
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The Murine Natural Cytotoxic Receptor NKp46/NCR1 Controls TRAIL Protein Expression in NK Cells and ILC1s by Sheppard, Sam, Schuster, Iona S., Andoniou, Christopher E., Cocita, Clement, Adejumo, Thomas, Kung, Sam K.P., Sun, Joseph C., Degli-Esposti, Mariapia A., Guerra, Nadia

“…TRAIL is an apoptosis-inducing ligand constitutively expressed on liver-resident type 1 innate lymphoid cells (ILC1s) and a subset of natural killer (NK)…”
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The Avidity Game: Selecting Natural-Born Killers by Andoniou, Christopher E., Schuster, Iona S., Degli-Esposti, Mariapia A.

“…Natural killer (NK) cells display some features equivalent to those of adaptive immune effectors, but the molecular processes underlying these adaptive-like…”
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IKAROS and AIOLOS directly regulate AP-1 transcriptional complexes and are essential for NK cell development by Goh, Wilford, Sudholz, Harrison, Foroutan, Momeneh, Scheer, Sebastian, Pfefferle, Aline, Delconte, Rebecca B., Meng, Xiangpeng, Shen, Zihan, Hennessey, Robert, Kong, Isabella Y., Schuster, Iona S., Andoniou, Christopher E., Davis, Melissa J., Hediyeh-Zadeh, Soroor, Souza-Fonseca-Guimaraes, Fernando, Parish, Ian A., Beavis, Paul, Thiele, Daniel, Chopin, Michael, Degli-Esposti, Mariapia A., Cursons, Joe, Kallies, Axel, Rautela, Jai, Nutt, Stephen L., Huntington, Nicholas D.

“…Ikaros transcription factors are essential for adaptive lymphocyte function, yet their role in innate lymphopoiesis is unknown. Using conditional genetic…”
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Infection induces tissue-resident memory NK cells that safeguard tissue health by Schuster, Iona S., Sng, Xavier Y.X., Lau, Colleen M., Powell, David R., Weizman, Orr-El, Fleming, Peter, Neate, Georgia E.G., Voigt, Valentina, Sheppard, Sam, Maraskovsky, Andreas I., Daly, Sheridan, Koyama, Motoko, Hill, Geoffrey R., Turner, Stephen J., O’Sullivan, Timothy E., Sun, Joseph C., Andoniou, Christopher E., Degli-Esposti, Mariapia A.

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Hhex Directly Represses BIM-Dependent Apoptosis to Promote NK Cell Development and Maintenance by Goh, Wilford, Scheer, Sebastian, Jackson, Jacob T., Hediyeh-Zadeh, Soroor, Delconte, Rebecca B., Schuster, Iona S., Andoniou, Christopher E., Rautela, Jai, Degli-Esposti, Mariapia A., Davis, Melissa J., McCormack, Matthew P., Nutt, Stephen L., Huntington, Nicholas D.

“…Hhex encodes a homeobox transcriptional regulator important for embryonic development and hematopoiesis. Hhex is highly expressed in NK cells, and its germline…”
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GVHD prevents NK-cell–dependent leukemia and virus-specific innate immunity by Bunting, Mark D., Varelias, Antiopi, Souza-Fonseca-Guimaraes, Fernando, Schuster, Iona S., Lineburg, Katie E., Kuns, Rachel D., Fleming, Peter, Locke, Kelly R., Huntington, Nicholas D., Blazar, Bruce R., Lane, Steven W., Tey, Siok-Keen, MacDonald, Kelli P.A., Smyth, Mark J., Degli-Esposti, Mariapia A., Hill, Geoffrey R.

“…Allogeneic bone marrow transplantation (allo-BMT) is a curative therapy for hematological malignancies, but is associated with significant complications,…”
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Ocular antigen does not cause disease unless presented in the context of inflammation by Voigt, Valentina, Wikstrom, Matthew E., Kezic, Jelena M., Schuster, Iona S., Fleming, Peter, Makinen, Kimmo, Daley, Stephen R., Andoniou, Christopher E., Degli-Esposti, Mariapia A., Forrester, John V.

“…Ocular antigens are sequestered behind the blood-retina barrier and the ocular environment protects ocular tissues from autoimmune attack. The signals required…”
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Cytomegalovirus establishes a latent reservoir and triggers long-lasting inflammation in the eye by Voigt, Valentina, Andoniou, Christopher E, Schuster, Iona S, Oszmiana, Anna, Ong, Monique L, Fleming, Peter, Forrester, John V, Degli-Esposti, Mariapia A

“…Recent outbreaks of Ebola and Zika have highlighted the possibility that viruses may cause enduring infections in tissues like the eye, including the neural…”
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A natural genetic variant of granzyme B confers lethality to a common viral infection by Andoniou, Christopher E, Sutton, Vivien R, Wikstrom, Matthew E, Fleming, Peter, Thia, Kevin Y T, Matthews, Antony Y, Kaiserman, Dion, Schuster, Iona S, Coudert, Jerome D, Eldi, Preethi, Chaudhri, Geeta, Karupiah, Gunasegaran, Bird, Phillip I, Trapani, Joseph A, Degli-Esposti, Mariapia A

“…Many immune response genes are highly polymorphic, consistent with the selective pressure imposed by pathogens over evolutionary time, and the need to balance…”
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Acute GVHD results in a severe DC defect that prevents T-cell priming and leads to fulminant cytomegalovirus disease in mice by Wikstrom, Matthew E., Fleming, Peter, Kuns, Rachel D., Schuster, Iona S., Voigt, Valentina, Miller, Gregory, Clouston, Andrew D., Tey, Siok-Keen, Andoniou, Christopher E., Hill, Geoffrey R., Degli-Esposti, Mariapia A.

“…Viral infection is a common, life-threatening complication after allogeneic bone marrow transplantation (BMT), particularly in the presence of…”
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