Search Results - "Schur, Rebecca M."

Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber’s Congenital Amaurosis by Sun, Da, Sahu, Bhubanananda, Gao, Songqi, Schur, Rebecca M., Vaidya, Amita M., Maeda, Akiko, Palczewski, Krzysztof, Lu, Zheng-Rong

“…Development of a gene delivery system with high efficiency and a good safety profile is essential for successful gene therapy. Here we developed a targeted…”
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MRI detection of breast cancer micrometastases with a fibronectin-targeting contrast agent by Zhou, Zhuxian, Qutaish, Mohammed, Han, Zheng, Schur, Rebecca M., Liu, Yiqiao, Wilson, David L., Lu, Zheng-Rong

“…Metastasis is the primary cause of death in breast cancer patients. Early detection of high-risk breast cancer, including micrometastasis, is critical in…”
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Suppression of electromagnetic interference in electroretinography from a patient with an implanted left ventricular assist device (LVAD) by Schur, Rebecca M., Eck, Brendan L., Yuan, Alex

“…Purpose A left ventricular assist device (LVAD) is an implantable cardiac pump that uses a magnetically-levitating rotor to pump blood into circulation for…”
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Non-viral Gene Therapy for Stargardt Disease with ECO/pRHO-ABCA4 Self-Assembled Nanoparticles by Sun, Da, Schur, Rebecca M., Sears, Avery E., Gao, Song-Qi, Vaidya, Amita, Sun, Wenyu, Maeda, Akiko, Kern, Timothy, Palczewski, Krzysztof, Lu, Zheng-Rong

“…Stargardt disease (STGD) is an autosomal recessive retinal disorder caused by a monogenic ABCA4 mutation. Currently, there is no effective therapy to cure…”
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Targeted Mesoporous Silica Nanoparticles Delivering Arsenic Trioxide with Environment Sensitive Drug Release for Effective Treatment of Triple Negative Breast Cancer by Wu, Xiaohui, Han, Zheng, Schur, Rebecca M, Lu, Zheng-Rong

“…In this study, we report a novel modality of using a mesoporous silica nanoparticles (MSNs)-based drug delivery system with RGD peptide as a targeting ligand…”
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New GABA modulators protect photoreceptor cells from light‐induced degeneration in mouse models by Schur, Rebecca M., Gao, Songqi, Yu, Guanping, Chen, Yu, Maeda, Akiko, Palczewski, Krzysztof, Lu, Zheng-Rong

“…ABSTRACT No clinically approved therapies are currently available that prevent the onset of photoreceptor death in retinal degeneration. Signaling between…”
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Electrical Control of Protein Conformation by Wan, Alwin M. D., Schur, Rebecca M., Ober, Christopher K., Fischbach, Claudia, Gourdon, Delphine, Malliaras, George G.

“…Conducting polymer devices that enable precise control of fibronectin conformation over macroscopic areas are reported. Single conformations as well as…”
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BEST1 Variant Associated with an Atypical Macular and Peripheral Retinal Phenotype by Singuri, Srinidhi, DeBenedictis, Meghan J, Traboulsi, Elias I, Yuan, Alex, Schur, Rebecca M

“…Best vitelliform macular dystrophy (BVMD) is an inherited macular dystrophy associated with over 250 pathogenic variants of the Bestrophin-1 (BEST1) gene…”
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Manganese-Enhanced MRI for Preclinical Evaluation of Retinal Degeneration Treatments by Schur, Rebecca M, Sheng, Li, Sahu, Bhubanananda, Yu, Guanping, Gao, Songqi, Yu, Xin, Maeda, Akiko, Palczewski, Krzysztof, Lu, Zheng-Rong

“…Apply manganese-enhanced magnetic resonance imaging (MEMRI) to assess ion channel activity and structure of retinas from mice subject to light-induced retinal…”
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A novel nonviral gene delivery system for treating Leber's congenital amaurosis by Sun, Da, Schur, Rebecca M, Lu, Zheng-Rong

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Stable Retinoid Analogue Targeted Dual pH-Sensitive Smart Lipid ECO/pDNA Nanoparticles for Specific Gene Delivery in the Retinal Pigment Epithelium by Sun, Da, Schur, Rebecca M, Sears, Avery E, Gao, Song-Qi, Sun, Wenyu, Naderi, Amirreza, Kern, Timothy, Palczewski, Krzysztof, Lu, Zheng-Rong

“…Dysfunctions caused by gene mutations in the retinal pigment epithelium (RPE) lead to retinal degeneration, visual function loss, and even blindness…”
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Initial evaluation of hepatic T1 relaxation time as an imaging marker of liver disease associated with autosomal recessive polycystic kidney disease (ARPKD) by Gao, Ying, Erokwu, Bernadette O., DeSantis, David A., Croniger, Colleen M., Schur, Rebecca M., Lu, Lan, Mariappuram, Jose, Dell, Katherine M., Flask, Chris A.

“…Autosomal recessive polycystic kidney disease (ARPKD) is a potentially lethal multi‐organ disease affecting both the kidneys and the liver. Unfortunately,…”
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Initial evaluation of hepatic T 1 relaxation time as an imaging marker of liver disease associated with autosomal recessive polycystic kidney disease (ARPKD) by Gao, Ying, Erokwu, Bernadette O., DeSantis, David A., Croniger, Colleen M., Schur, Rebecca M., Lu, Lan, Mariappuram, Jose, Dell, Katherine M., Flask, Chris A.

“…Autosomal recessive polycystic kidney disease (ARPKD) is a potentially lethal multi‐organ disease affecting both the kidneys and the liver. Unfortunately,…”
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Initial evaluation of hepatic T sub(1) relaxation time as an imaging marker of liver disease associated with autosomal recessive polycystic kidney disease (ARPKD) by Gao, Ying, Erokwu, Bernadette O, DeSantis, David A, Croniger, Colleen M, Schur, Rebecca M, Lu, Lan, Mariappuram, Jose, Dell, Katherine M, Flask, Chris A

“…Autosomal recessive polycystic kidney disease (ARPKD) is a potentially lethal multi-organ disease affecting both the kidneys and the liver. Unfortunately,…”
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Design and Evaluation of Prophylactic Therapies to Prevent Retinal Degeneration in Mouse Models of Stargardt Disease by Schur, Rebecca M

“…Stargardt Disease (STGD) is a juvenile-onset inherited retinal dystrophy that affects 1/8,000-1/10,000 individuals. Patients with STGD are born with normal…”
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