Search Results - "Schupsky, James J."

Topiramate: preclinical evaluation of structurally novel anticonvulsant by Shank, R P, Gardocki, J F, Vaught, J L, Davis, C B, Schupsky, J J, Raffa, R B, Dodgson, S J, Nortey, S O, Maryanoff, B E

“…Topiramate [TPM, 2,3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate] (RWJ-17021-000, formerly McN-4853) is a structurally novel antiepileptic…”
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Enhanced therapeutic effects of liposome-associated 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine by AHMAD, I, FILEP, J. J, FRANKLIN, J. C, JANOFF, A. S, MASTERS, G. R, PATTASSERY, J, PETERS, A, SCHUPSKY, J. J, ZHA, Y, MAYHEW, E

“…The ether-lipid 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine (ET-18-OCH3) has anticancer activity, but systemic toxicity has restricted its therapeutic…”
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Structure−Activity Studies on Anticonvulsant Sugar Sulfamates Related to Topiramate. Enhanced Potency with Cyclic Sulfate Derivatives by Maryanoff, Bruce E, Costanzo, Michael J, Nortey, Samuel O, Greco, Michael N, Shank, Richard P, Schupsky, James J, Ortegon, Marta P, Vaught, Jeffry L

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Structure−Activity Studies on Anticonvulsant Sugar Sulfamates Related to Topiramate. Enhanced Potency with Cyclic Sulfate Derivatives by Maryanoff, Bruce E., Costanzo, Michael J., Nortey, Samuel O., Greco, Michael N., Shank, Richard P., Schupsky, James J., Ortegon, Marta P., Vaught, Jeffry L.

“…We have explored the structure−activity relationship (SAR) surrounding the clinically efficacious antiepileptic drug topiramate (1), a unique sugar sulfamate…”
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Endothelin-induced nociception in mice: mediation by ETA and ETB receptors by Raffa, R B, Schupsky, J J, Jacoby, H I

“…Endothelins (ET-1, ET-2 or ET-3) or endothelin precursors (big-ET-1[1-38], big-ET-2[1-37] or big-ET-3[1-41]) injected i.p. in mice have previously been shown…”
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Characterization of endothelin-induced nociception in mice: evidence for a mechanistically distinct analgesic model by Raffa, R B, Schupsky, J J, Lee, D K, Jacoby, H I

“…The behavioral response elicited in mice by an i.p. injection of endothelin-1 (ET-1) (0.1 mg/kg) was differentiated from that elicited by standard agents such…”
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Opioid mu receptor subtypes (possibly mu 1 and mu 2) revealed by morphine-induced antinociception vs endothelin-1 in recombinant inbred CXBK mice by Raffa, R B, Schupsky, J J

“…Morphine was administered intracerebroventricularly to normal or recombinant inbred CXBK (mu-opioid receptor deficient) mice and antinociception was determined…”
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Growth inhibition of a human ovarian tumor by a novel paclitaxel derivative in SCID mice by Ahmad, I, Masters, G R, Schupsky, J J, Nguyen, J, Ali, S, Janoff, A S, Mayhew, E

“…We report here the toxicity and therapeutic effects of 2'-alpha-bromohexadecanoyl paclitaxel (BrC16HT), a prodrug form of paclitaxel, in mice. Paclitaxel is…”
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Unexpected antinociceptive effect of the N-oxide (RWJ 38705) of tramadol hydrochloride by Raffa, R B, Haslego, M L, Maryanoff, C A, Villani, F J, Codd, E E, Connelly, C D, Martinez, R P, Schupsky, J J, Buben, J A, Wu, W N, Takacs, A N, Mckown, L A

“…N-Oxides of centrally acting analgesics generally have minimal analgesic activity. However, the N-oxide of tramadol produced dose-related, long-lasting…”
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Endothelin-1-induced nociception by Raffa, R B, Schupsky, J J, Martinez, R P, Jacoby, H I

“…Intracerebroventricular (i.c.v.) or intrathecal (i.t.) administration of morphine to mice antagonized the abdominal constriction induced by an i.p. injection…”
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