Search Results - "Schunkert, Heribert"

Family or SNPs: what counts for hereditary risk of coronary artery disease? by Schunkert, Heribert

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A decade of genome-wide association studies for coronary artery disease: the challenges ahead by Erdmann, Jeanette, Kessler, Thorsten, Munoz Venegas, Loreto, Schunkert, Heribert

“…Abstract In this review, we summarize current knowledge on the genetics of coronary artery disease, based on 10 years of genome-wide association studies. The…”
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The impact of genome‐wide association studies on the pathophysiology and therapy of cardiovascular disease by Kessler, Thorsten, Vilne, Baiba, Schunkert, Heribert

“…Cardiovascular diseases are leading causes for death worldwide. Genetic disposition jointly with traditional risk factors precipitates their manifestation…”
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DNA methylation and body-mass index: a genome-wide analysis by Dick, Katherine J, PhD, Nelson, Christopher P, PhD, Tsaprouni, Loukia, PhD, Sandling, Johanna K, PhD, Aïssi, Dylan, MSc, Wahl, Simone, MSc, Meduri, Eshwar, PhD, Morange, Pierre-Emmanuel, Prof, Gagnon, France, PhD, Grallert, Harald, PhD, Waldenberger, Melanie, PhD, Peters, Annette, Prof, Erdmann, Jeanette, Prof, Hengstenberg, Christian, Prof, Cambien, Francois, Prof, Goodall, Alison H, Prof, Ouwehand, Willem H, Prof, Schunkert, Heribert, Prof, Thompson, John R, Prof, Spector, Tim D, FRCP, Gieger, Christian, PhD, Trégouët, David-Alexandre, PhD, Deloukas, Panos, Prof, Samani, Nilesh J, Prof

“…Summary Background Obesity is a major health problem that is determined by interactions between lifestyle and environmental and genetic factors. Although…”
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Applications and Limitations of Mouse Models for Understanding Human Atherosclerosis by von Scheidt, Moritz, Zhao, Yuqi, Kurt, Zeyneb, Pan, Calvin, Zeng, Lingyao, Yang, Xia, Schunkert, Heribert, Lusis, Aldons J.

“…Most of the biological understanding of mechanisms underlying coronary artery disease (CAD) derives from studies of mouse models. The identification of…”
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Everolimus-eluting bioresorbable vascular scaffolds versus everolimus-eluting metallic stents: a meta-analysis of randomised controlled trials by Cassese, Salvatore, Dr, Byrne, Robert A, PhD, Ndrepepa, Gjin, Prof, Kufner, Sebastian, MD, Wiebe, Jens, MD, Repp, Janika, MD, Schunkert, Heribert, Prof, Fusaro, Massimiliano, MD, Kimura, Takeshi, Prof, Kastrati, Adnan, Prof

“…Summary Background Bioresorbable coronary stents might improve outcomes of patients treated with percutaneous coronary interventions. The everolimus-eluting…”
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Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel by Borén, Jan, Chapman, M John, Krauss, Ronald M, Packard, Chris J, Bentzon, Jacob F, Binder, Christoph J, Daemen, Mat J, Demer, Linda L, Hegele, Robert A, Nicholls, Stephen J, Nordestgaard, Børge G, Watts, Gerald F, Bruckert, Eric, Fazio, Sergio, Ference, Brian A, Graham, Ian, Horton, Jay D, Landmesser, Ulf, Laufs, Ulrich, Masana, Luis, Pasterkamp, Gerard, Raal, Frederick J, Ray, Kausik K, Schunkert, Heribert, Taskinen, Marja-Riitta, van de Sluis, Bart, Wiklund, Olov, Tokgozoglu, Lale, Catapano, Alberico L, Ginsberg, Henry N

“…Abstract…”
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Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel by Ference, Brian A, Ginsberg, Henry N, Graham, Ian, Ray, Kausik K, Packard, Chris J, Bruckert, Eric, Hegele, Robert A, Krauss, Ronald M, Raal, Frederick J, Schunkert, Heribert, Watts, Gerald F, Borén, Jan, Fazio, Sergio, Horton, Jay D, Masana, Luis, Nicholls, Stephen J, Nordestgaard, Børge G, van de Sluis, Bart, Taskinen, Marja-Riitta, Tokgözoglu, Lale, Landmesser, Ulf, Laufs, Ulrich, Wiklund, Olov, Stock, Jane K, Chapman, M John, Catapano, Alberico L

“…To appraise the clinical and genetic evidence that low-density lipoproteins (LDLs) cause atherosclerotic cardiovascular disease (ASCVD). We assessed whether…”
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Impact of Acute and Chronic Psychosocial Stress on Vascular Inflammation by Hinterdobler, Julia, Schunkert, Heribert, Kessler, Thorsten, Sager, Hendrik B

“…Atherosclerosis and its complications, such as acute coronary syndromes, are the leading causes of death worldwide. A wide range of inflammatory processes…”
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Genomic prediction of coronary heart disease by Abraham, Gad, Havulinna, Aki S, Bhalala, Oneil G, Byars, Sean G, De Livera, Alysha M, Yetukuri, Laxman, Tikkanen, Emmi, Perola, Markus, Schunkert, Heribert, Sijbrands, Eric J, Palotie, Aarno, Samani, Nilesh J, Salomaa, Veikko, Ripatti, Samuli, Inouye, Michael

“…Genetics plays an important role in coronary heart disease (CHD) but the clinical utility of genomic risk scores (GRSs) relative to clinical risk scores, such…”
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Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia by Khera, Amit V., MD, Won, Hong-Hee, PhD, Peloso, Gina M., PhD, Lawson, Kim S., MS, Bartz, Traci M., MS, Deng, Xuan, MSc, van Leeuwen, Elisabeth M, Natarajan, Pradeep, MD, MMSc, Emdin, Connor A., HBSc, Bick, Alexander G., PhD, Morrison, Alanna C., PhD, Brody, Jennifer A., BA, Gupta, Namrata, PhD, Nomura, Akihiro, MD, Kessler, Thorsten, MD, Duga, Stefano, PhD, Bis, Joshua C., PhD, van Duijn, Cornelia M., PhD, Cupples, L. Adrienne, PhD, Psaty, Bruce, MD, PhD, Rader, Daniel J., MD, Danesh, John, DPhil, Schunkert, Heribert, MD, McPherson, Ruth, MD, Farrall, Martin, MD, Watkins, Hugh, MD, PhD, Lander, Eric, PhD, Wilson, James G., MD, Correa, Adolfo, MD, PhD, Boerwinkle, Eric, PhD, Merlini, Piera Angelica, MD, Ardissino, Diego, MD, Saleheen, Danish, MBBS, PhD, Gabriel, Stacey, PhD, Kathiresan, Sekar, MD

“…Abstract Background Approximately 7% of American adults have severe hypercholesterolemia (untreated low-density lipoprotein [LDL] cholesterol ≥190 mg/dl),…”
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P2Y12 Inhibitor or Aspirin Monotherapy for Secondary Prevention of Coronary Events by Gragnano, Felice, Cao, Davide, Pirondini, Leah, Franzone, Anna, Kim, Hyo-Soo, von Scheidt, Moritz, Pettersen, Alf-Åge R., Zhao, Qiang, Woodward, Mark, Chiarito, Mauro, McFadden, Eugene P., Park, Kyung Woo, Kastrati, Adnan, Seljeflot, Ingebjørg, Zhu, Yunpeng, Windecker, Stephan, Kang, Jeehoon, Schunkert, Heribert, Arnesen, Harald, Bhatt, Deepak L., Steg, Philippe Gabriel, Calabrò, Paolo, Pocock, Stuart, Mehran, Roxana, Valgimigli, Marco

“…Aspirin is the only antiplatelet agent with a Class I recommendation for long-term prevention of cardiovascular events in patients with coronary artery disease…”
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C-Reactive Protein and Coronary Heart Disease: All Said-Is Not It? by Strang, Frederik, Schunkert, Heribert

“…C-reactive protein (CRP) and coronary heart disease (CHD) have been the subject of intensive investigations over the last decades. Epidemiological studies have…”
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Risk Prediction of Cardiovascular Events by Exploration of Molecular Data with Explainable Artificial Intelligence by Westerlund, Annie M, Hawe, Johann S, Heinig, Matthias, Schunkert, Heribert

“…Cardiovascular diseases (CVD) annually take almost 18 million lives worldwide. Most lethal events occur months or years after the initial presentation. Indeed,…”
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Bayesian multiple logistic regression for case-control GWAS by Banerjee, Saikat, Zeng, Lingyao, Schunkert, Heribert, Söding, Johannes

“…Genetic variants in genome-wide association studies (GWAS) are tested for disease association mostly using simple regression, one variant at a time. Standard…”
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A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease by Emdin, Connor A, Haas, Mary E, Khera, Amit V, Aragam, Krishna, Chaffin, Mark, Klarin, Derek, Hindy, George, Jiang, Lan, Wei, Wei-Qi, Feng, Qiping, Karjalainen, Juha, Havulinna, Aki, Kiiskinen, Tuomo, Bick, Alexander, Ardissino, Diego, Wilson, James G, Schunkert, Heribert, McPherson, Ruth, Watkins, Hugh, Elosua, Roberto, Bown, Matthew J, Samani, Nilesh J, Baber, Usman, Erdmann, Jeanette, Gupta, Namrata, Danesh, John, Saleheen, Danish, Chang, Kyong-Mi, Vujkovic, Marijana, Voight, Ben, Damrauer, Scott, Lynch, Julie, Kaplan, David, Serper, Marina, Tsao, Philip, Mercader, Josep, Hanis, Craig, Daly, Mark, Denny, Joshua, Gabriel, Stacey, Kathiresan, Sekar

“…Analyzing 12,361 all-cause cirrhosis cases and 790,095 controls from eight cohorts, we identify a common missense variant in the Mitochondrial Amidoxime…”
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Long-term Outcomes After MitraClip Implantation According to Presence or Absence of EVEREST Inclusion Criteria by Lesevic, Hasema, MD, Karl, Michael, MD, Braun, Daniel, MD, Barthel, Petra, MD, Orban, Martin, MD, Pache, Jürgen, MD, Hadamitzky, Martin, MD, Mehilli, Julinda, MD, Stecher, Lynne, PhD, Massberg, Steffen, MD, PhD, Ott, Ilka, MD, Schunkert, Heribert, MD, Kastrati, Adnan, MD, Sonne, Carolin, MD, Hausleiter, Jörg, MD

“…Abstract Numerous patients are treated with the MitraClip, although they do not fulfill the stringent inclusion criteria of the EVEREST (Endovascular Valve…”
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Predictors of Permanent Pacemaker Implantations and New-Onset Conduction Abnormalities With the SAPIEN 3 Balloon-Expandable Transcatheter Heart Valve by Husser, Oliver, MD, Pellegrini, Costanza, MD, Kessler, Thorsten, MD, Burgdorf, Christof, MD, Thaller, Hannah, Mayr, N. Patrick, MD, Kasel, Albert M., MD, Kastrati, Adnan, MD, Schunkert, Heribert, MD, Hengstenberg, Christian, MD

“…Abstract Objectives This study investigates the influence of implantation depth and prosthesis oversizing on conduction abnormalities (CA) and permanent…”
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Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome by Charchar, Fadi J, PhD, Bloomer, Lisa DS, MSc, Barnes, Timothy A, PhD, Cowley, Mark J, PhD, Nelson, Christopher P, PhD, Wang, Yanzhong, PhD, Denniff, Matthew, BSc, Debiec, Radoslaw, MD, Christofidou, Paraskevi, MSc, Nankervis, Scott, PhD, Dominiczak, Anna F, MD, Bani-Mustafa, Ahmed, PhD, Balmforth, Anthony J, MD, Hall, Alistair S, MD, Erdmann, Jeanette, PhD, Cambien, Francois, PhD, Deloukas, Panos, PhD, Hengstenberg, Christian, MD, Packard, Chris, MD, Schunkert, Heribert, MD, Ouwehand, Willem H, MD, Ford, Ian, PhD, Goodall, Alison H, PhD, Jobling, Mark A, PhD, Samani, Nilesh J, MD, Tomaszewski, Maciej, Dr

“…Summary Background A sexual dimorphism exists in the incidence and prevalence of coronary artery disease—men are more commonly affected than are age-matched…”
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Extending bioelectric navigation for displacement and direction detection by Maier, Heiko, Schunkert, Heribert, Navab, Nassir

“…Purpose Bioelectric navigation is a navigation modality for minimally invasive endovascular procedures promising non-fluoroscopic navigation. However, the…”
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