Search Results - "Schuman, Mariano"

Antiaging Gene Klotho Regulates Adrenal CYP11B2 Expression and Aldosterone Synthesis by Zhou, Xiaoli, Chen, Kai, Wang, Yongjun, Schuman, Mariano, Lei, Han, Sun, Zhongjie

“…Deficiency of the antiaging gene Klotho (KL) induces renal damage and hypertension through unknown mechanisms. In this study, we assessed whether KL regulates…”
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Short-term doxorubicin cardiotoxic effects: involvement of cardiac Thyrotropin Releasing Hormone system by Peres Diaz, Ludmila Soledad, Schuman, Mariano Luis, Aisicovich, Maia, Toblli, Jorge Eduardo, Pirola, Carlos José, Landa, María Silvina, García, Silvia Inés

“…Doxorubicin is an antineoplastic in the anthracycline class widely used for the treatment of several solid tumors and blood cancers. Cardiotoxicity is the…”
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Valproate decreases transgenerationally blood pressure by affecting thyrotropin-releasing hormone promoter DNA methylation and gene expression in spontaneously hypertensive rat by Landa, María S, Schuman, Mariano L, Aisicovich, Maia, Peres Diaz, Ludmila S, Gironacci, Mariela M, García, Silvia I, Pirola, Carlos J

“…Central TRH, a neuropeptide, is involved in cardiovascular regulation. We demonstrated that the overexpression of diencephalic TRH (dTRH) in SHR rats can be…”
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Angiotensin II requires an intact cardiac thyrotropin-releasing hormone (TRH) system to induce cardiac hypertrophy in mouse by Peres Diaz, Ludmila S., Schuman, Mariano Luis, Aisicovich, Maia, Toblli, Jorge Eduardo, Pirola, Carlos José, Landa, María Silvina, García, Silvia Inés

“…Cardiac tyhrotropin-releasing hormone (TRH) is overexpressed in the hypertrophied left ventricle (LV) of spontaneously hypertensive rats (SHR) and its…”
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Cardiac Thyrotropin-releasing Hormone Inhibition Improves Ventricular Function and Reduces Hypertrophy and Fibrosis After Myocardial Infarction in Rats by Schuman, Mariano L., Peres Diaz, Ludmila S., Aisicovich, Maia, Ingallina, Fernando, Toblli, Jorge E., Landa, Maria S., García, Silvia I.

“…Cardiac thyrotropin-releasing hormone (TRH) is a tripeptide with still unknown functions. We demonstrated that the left ventricle (LV) TRH system is…”
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Therapeutic Effect of Alpha Lipoic Acid in a Rat Preclinical Model of Preeclampsia: Focus on Maternal Signs, Fetal Growth and Placental Function by Barrientos, Gabriela, Schuman, Mariano L, Landa, Maria S, Robello, Elizabeth, Incardona, Claudio, Conrad, Melanie L, Galleano, Monica, García, Silvia I

“…Chronic hypertension is a major risk factor for preeclampsia (PE), associated with significant maternal and neonatal morbidity. We previously demonstrated that…”
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Thyrotropin-releasing hormone overexpression induces structural changes of the left ventricle in the normal rat heart by Schuman, Mariano L, Peres Diaz, Ludmila S, Landa, Maria S, Toblli, Jorge E, Cao, Gabriel, Alvarez, Azucena L, Finkielman, Samuel, Pirola, Carlos J, García, Silvia I

“…Thyrotropin-releasing hormone (TRH) hyperactivity has been observed in the left ventricle of spontaneously hypertensive rats. Its long-term inhibition…”
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Integrative study of hypothalamus–pituitary–thyroid–immune system interaction: thyroid hormone-mediated modulation of lymphocyte activity through the protein kinase C signaling pathway by Klecha, Alicia J, Genaro, Ana M, Gorelik, Gabriela, Barreiro Arcos, María Laura, Silberman, Dafne Magalí, Schuman, Mariano, Garcia, Silvia I, Pirola, Carlos, Cremaschi, Graciela A

“…Thyroid hormones play critical roles in differentiation, growth and metabolism, but their participation in immune system regulation has not been completely…”
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Cardiac Thyrotropin-Releasing Hormone Mediates Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats by Schuman, Mariano L, Landa, Maria S, Toblli, Jorge E, Peres Diaz, Ludmila S, Alvarez, Azucena L, Finkielman, Samuel, Paz, Leonardo, Cao, Gabriel, Pirola, Carlos J, García, Silvia I

“…Local thyrotropin-releasing hormone (TRH) may be involved in cardiac pathophysiology, but its role in left ventricular hypertrophy (LVH) is still unknown. We…”
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Knocking down the diencephalic thyrotropin-releasing hormone precursor gene normalizes obesity-induced hypertension in the rat by Landa, María S, García, Silvia I, Schuman, Mariano L, Burgueño, Adriana, Alvarez, Azucena L, Saravia, Flavia E, Gemma, Carolina, Pirola, Carlos J

“…We recently showed that diencephalic TRH may mediate the central leptin-induced pressor effect. Here, to study the role of TRH in obesity-induced hypertension…”
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Thyrotropin-Releasing Hormone Precursor Gene Knocking Down Impedes Melanocortin-Induced Hypertension in Rats by Landa, María S, García, Silvia I, Schuman, Mariano L, Alvarez, Azucena L, Finkielman, Samuel, Pirola, Carlos J

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Association between diencephalic thyroliberin and arterial blood pressure in agouti-yellow and ob/ob mice may be mediated by leptin by Burgueño, Adriana L, Landa, Maria S, Schuman, Mariano L, Alvarez, Azucena L, Carabelli, Julieta, García, Silvia I, Pirola, Carlos J

“…Abstract Leptin, a hormone secreted by the adipose tissue, stimulates anorexigenic peptides and also inhibits orexigenic peptides in hypothalamic arcuate…”
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SiRNA-mediated silencing of the diencephalic thyrotropin-releasing hormone precursor gene decreases the arterial blood pressure in the obese agouti mice by Landa, Maria Silvina, Schuman, Mariano Luis, Burgueno, Adriana, Alvarez, Azucena Laura, Garcia, Silvia Ines, Pirola, Carlos Jose

“…Obesity is associated with increased cardiovascular morbidity and mortality, in part through development of hypertension. Leptin promotes weight loss by…”
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Lipoic acid supplementation in a preclinical model of preeclampsia mitigates maternal signs and fetal growth restriction through improved placental function by Barrientos, Gabriela, Schuman, Mariano, Landa, María Silvina, Robello, Elizabeth, Incardona, Claudio, Galleano, Monica, García, Silvia I.

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Abstract 521: Upregulation of Fibroblast Growth Factor 23 Contributes to Klotho Gene Deficiency-induced Hypertension by Schuman, Mariano, Sun, Zhongjie

“…Abstract only Objective. Klotho is a newly-discovered anti-aging gene. Klotho (KL) gene delivery prevented progression of spontaneous hypertension and…”
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Abstract 10695: Early Overnutrition in Rats Induces Premature Cardiac Alterations Independently of Blood Pressure: Leptin-TRH Pathway Involvement by Aisicovich, Maia, Rosati, Macarena Luz, Schuman, Mariano, Giardina, Graciela L, Landa, MarÃa Silvina, Garcia, Silvia

“…Animal models are an interesting tool to evaluate future consequences of early nutritional insults. We described in adult mice thatleptin induces cardiac cTRH,…”
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Inhibition fibroblast growth factor receptor (FGFR) attenuates anti‐aging gene klotho deficiency induced hypertension by Schuman, Mariano, Sun, Zhongjie

“…Abstract only Klotho is a newly‐discovered anti‐aging gene. Klotho (KL) gene delivery prevented progression of spontaneous hypertension and attenuated kidney…”
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Parathyroid hormone-related protein overexpression decreases blood pressure in spontaneously hypertensive rats by LANDA, Maria S, GARCIA, Silvia I, LIBERJEN, Leonardo, SCHUMAN, Mariano L, FINKIELMAN, Samuel, PIROLA, Carlos J

“…We have recently demonstrated that arterial PTHrP expression and cardiovascular responses to this protein are altered in SHR compared with normotensive…”
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Metabolic dysfunction-associated steatotic liver disease exhibits sex-specific microbial heterogeneity within intestinal compartments by Pirola, Carlos Jose, Landa, Maria Silvina, Schuman, Mariano, García, Silvia Inés, Salatino, Adrian, Sookoian, Silvia

“…Evidence suggests that the gastrointestinal microbiome plays a significant role in the biology of metabolic dysfunction-associated steatotic liver disease…”
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Novel Leptin-Cardiac TRH pathway responsible for the cardiac alterations in the Hyperleptinemic obesity by Peres Díaz, Ludmila Soledad, Aisicovich, Maia, Schuman, Mariano Luis, Rosati, Macarena, Toblli, Jorge Eduardo, Uceda, Ana, Giardina, Graciela, Landa, María Silvina, García, Silvia Inés

“…The association between hypertension and obesity-induced cardiac damage is usually accepted. However, no studies have been focused on cardiac alterations in…”
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