Search Results - "Schumacker, P. T."

Role of hypoxia-inducible factor in cell survival during myocardial ischemia-reperfusion by Loor, G, Schumacker, P T

“…Hypoxia-inducible factor (HIF) is the principal transcription factor involved in the regulation of transcriptional responses to hypoxia. During hypoxia, HIF- α…”
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Mitochondrial Reactive Oxygen Species Trigger Hypoxia-Induced Transcription by Chandel, N. S., Maltepe, E., Goldwasser, E., Mathieu, C.E., Simon, M. C., Schumacker, P. T.

“…Transcriptional activation of erythropoietin, glycolytic enzymes, and vascular endothelial growth factor occurs during hypoxia or in response to cobalt…”
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Cellular oxygen sensing by mitochondria: old questions, new insight by Chandel, Navdeep S, Schumacker, Paul T

“…The University of Chicago, Pulmonary and Critical Care Medicine, Chicago, Illinois 60637 Hypoxia elicits a variety of adaptive responses at the tissue level,…”
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Role of mitochondrial hOGG1 and aconitase in oxidant-induced lung epithelial cell apoptosis by Panduri, V., Liu, G., Surapureddi, S., Kondapalli, J., Soberanes, S., de Souza-Pinto, N.C., Bohr, V.A., Budinger, G.R.S., Schumacker, P.T., Weitzman, S.A., Kamp, D.W.

“…8-Oxoguanine DNA glycosylase (Ogg1) repairs 8-oxo-7,8-dihydroxyguanine (8-oxoG), one of the most abundant DNA adducts caused by oxidative stress. In the…”
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Preconditioning in Cardiomyocytes Protects by Attenuating Oxidant Stress at Reperfusion by Hoek, Terry L. Vanden, Becker, Lance B, Shao, Zuo-Hui, Li, Chang-Qing, Schumacker, Paul T

“…ABSTRACTCardiomyocyte death after ischemia/reperfusion correlates with oxidant stress, and antioxidants confer protection in that model. Preconditioning (PC)…”
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The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson's disease by Surmeier, D.J, Guzman, J.N, Sanchez-Padilla, J, Schumacker, P.T

“…Abstract Parkinson's disease (PD) is the second most common neurodegenerative disease in developed countries. The core motor symptoms are attributable to the…”
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Reperfusion injury on cardiac myocytes after simulated ischemia by Vanden Hoek, T L, Shao, Z, Li, C, Zak, R, Schumacker, P T, Becker, L B

“…The extent of cardiac injury incurred during reperfusion as opposed to that occurring during ischemia is unclear. This study tested the hypothesis that…”
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Redox regulation of p53 during hypoxia by CHANDEL, N. S, VANDER HEIDEN, M. G, THOMPSON, C. B, SCHUMACKER, P. T

“…The transcription factor p53 can induce growth arrest or death in cells. Tumor cells that develop mutations in p53 demonstrate a diminished apoptotic…”
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Cytotoxicity induced by grape seed proanthocyanidins: role of nitric oxide by Shao, Z H, Hsu, C W, Chang, W T, Waypa, G B, Li, J, Li, D, Li, C Q, Anderson, T, Qin, Y, Schumacker, P T, Becker, L B, Hoek, T L Vanden

“…Grape seed proanthocyanidin extract (GPSE) at high doses has been shown to exhibit cytotoxicity that is associated with increased apoptotic cell death. Nitric…”
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Oxygen conformance of cellular respiration in hepatocytes by Schumacker, P T, Chandel, N, Agusti, A G

“…Cellular respiratory rates are normally determined by metabolic activity, but become rate limited by O2 availability if the cell O2 tension (PO2) falls below a…”
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TRAF4 Deficiency Leads to Tracheal Malformation with Resulting Alterations in Air Flow to the Lungs by Shiels, Helena, Li, Xiantang, Schumacker, Paul T., Maltepe, Emin, Padrid, Philip A., Sperling, Anne, Thompson, Craig B., Lindsten, Tullia

“…TRAF4 is one of six identified members of the family of TNFR-associated factors. While the other family members have been found to play important roles in the…”
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Oxygen supply dependency in critical illness: an evolving understanding by Schumacker, P T

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Pathological supply dependence of systemic and intestinal O2 uptake during endotoxemia by Nelson, D P, Samsel, R W, Wood, L D, Schumacker, P T

“…When systemic delivery of oxygen (QO2 = blood flow X arterial O2 content) is reduced, the systemic O2 extraction ratio [(CaO2 - CVO2)/CaO2; where CaO2 is…”
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The concept of a critical oxygen delivery by SCHUMACKER, P. T, CAIN, S. M

“…In healthy tissues, decreases in oxygen delivery (QO2 = cardiac output X arterial O2 content) do not lower oxygen consumption (VO2) because tissue O2…”
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Inhibition of cytochrome-c oxidase activity during prolonged hypoxia by Chandel, N, Budinger, G R, Kemp, R A, Schumacker, P T

“…During acute (< 30 min) hypoxia, cellular respiration is independent of the O2 concentration as long as PO2 remains above a critical value (5-10 Torr)…”
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Cellular energy utilization and supply during hypoxia in embryonic cardiac myocytes by Budinger, G R, Chandel, N, Shao, Z H, Li, C Q, Melmed, A, Becker, L B, Schumacker, P T

“…Studies of intact hearts suggest that cardiac myocytes may have the ability to reversibly suppress metabolic activity and energy demand in states of regional…”
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Regulation of perfused capillary density in canine intestinal mucosa during endotoxemia by Drazenovic, R, Samsel, R W, Wylam, M E, Doerschuk, C M, Schumacker, P T

“…When O2 delivery (blood flow X arterial O2 content) is reduced, many tissues respond by increasing perfused capillary density. This facilitates the increase in…”
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Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin by Chandel, N S, Trzyna, W C, McClintock, D S, Schumacker, P T

“…The transcription factor NF-kappa B stimulates the transcription of proinflammatory cytokines including TNF-alpha. LPS (endotoxin) and hypoxia both induce…”
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Calcium Entry and  -Synuclein Inclusions Elevate Dendritic Mitochondrial Oxidant Stress in Dopaminergic Neurons by Dryanovski, D. I., Guzman, J. N., Xie, Z., Galteri, D. J., Volpicelli-Daley, L. A., Lee, V. M.- Y., Miller, R. J., Schumacker, P. T., Surmeier, D. J.

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Model for Hypoxic Pulmonary Vasoconstriction Involving Mitochondrial Oxygen Sensing by Waypa, Gregory B, Chandel, Navdeep S, Schumacker, Paul T

“…Wetested whether mitochondria function as the O 2 sensorunderlying hypoxic pulmonary vasoconstriction (HPV). In buffer-perfused ratlungs, rotenone,…”
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