Search Results - "Schumacher, Adi"

Orally Active Peptides: Is There a Magic Bullet? by Räder, Andreas F. B., Weinmüller, Michael, Reichart, Florian, Schumacher‐Klinger, Adi, Merzbach, Shira, Gilon, Chaim, Hoffman, Amnon, Kessler, Horst

“…For decades, the development of peptides as potential drugs was aimed solely at peptides with the highest affinity, receptor selectivity, or stability against…”
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Enhancing Oral Bioavailability of Cyclic RGD Hexa-peptides by the Lipophilic Prodrug Charge Masking Approach: Redirection of Peptide Intestinal Permeability from a Paracellular to Transcellular Pathway by Schumacher-Klinger, Adi, Fanous, Joseph, Merzbach, Shira, Weinmüller, Michael, Reichart, Florian, Räder, Andreas F. B, Gitlin-Domagalska, Agata, Gilon, Chaim, Kessler, Horst, Hoffman, Amnon

“…Hydrophilic peptides constitute most of the active peptides. They mostly permeate via tight junctions (paracellular pathway) in the intestine. This…”
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Cyclizing Painkillers: Development of Backbone-Cyclic TAPS Analogs by Talhami, Alaa, Swed, Avi, Hess, Shmuel, Ovadia, Oded, Greenberg, Sarit, Schumacher-Klinger, Adi, Rosenthal, David, Shalev, Deborah E., Hurevich, Mattan, Lazarovici, Philip, Hoffman, Amnon, Gilon, Chaim

“…Painkillers are commonly used medications. Native peptide painkillers suffer from various pharmacological disadvantages, while small molecule painkillers like…”
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Synthesis and Pharmacological Characterization of Visabron, a Backbone Cyclic Peptide Dual Antagonist of α4β1 (VLA-4)/α9β1 Integrin for Therapy of Multiple Sclerosis by Gilon, Chaim, Klazas, Michal, Lahiani, Adi, Schumacher-Klinger, Adi, Merzbach, Shira, Naoum, Johnny N, Ovadia, Haim, Rubin, Limor, Cornell-Kennon, Susan, Schaefer, Erik M, Katzhendler, Jehoshua, Marcinkiewicz, Cezary, Hoffman, Amnon, Lazarovici, Philip

“…Integrins α4β1/ α9β1 are important in the pathogenesis and progression of inflammatory and autoimmune diseases by their roles in leukocyte activation and…”
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Development of a Novel Backbone Cyclic Peptide Inhibitor of the Innate Immune TLR/IL1R Signaling Protein MyD88 by Dishon, Shira, Schumacher, Adi, Fanous, Joseph, Talhami, Alaa, Kassis, Ibrahim, Karussis, Dimitrios, Gilon, Chaim, Hoffman, Amnon, Nussbaum, Gabriel

“…MyD88 is a cytoplasmic adaptor protein that plays a central role in signaling downstream of the TLRs and the IL1R superfamily. We previously demonstrated that…”
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Overcoming the Lack of Oral Availability of Cyclic Hexapeptides: Design of a Selective and Orally Available Ligand for the Integrin αvβ3 by Weinmüller, Michael, Rechenmacher, Florian, Kiran Marelli, Udaya, Reichart, Florian, Kapp, Tobias G., Räder, Andreas F. B., Di Leva, Francesco Saverio, Marinelli, Luciana, Novellino, Ettore, Muñoz‐Félix, José M., Hodivala‐Dilke, Kairbaan, Schumacher, Adi, Fanous, Joseph, Gilon, Chaim, Hoffman, Amnon, Kessler, Horst

“…A highly systematic approach for the development of both orally bioavailable and bioactive cyclic N‐methylated hexapeptides as high affinity ligands for the…”
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Overcoming the Lack of Oral Availability of Cyclic Hexapeptides: Design of a Selective and Orally Available Ligand for the Integrin[alpha]v[beta]3 by Weinmuller, Michael, Rechenmacher, Florian, KiranMarelli, Udaya, Reichart, Florian, Kapp, Tobias G, Rader, Andreas F B, DiLeva, Francesco Saverio, Marinelli, Luciana, Novellino, Ettore, Munoz-Felix, José M, Hodivala-Dilke, Kairbaan, Schumacher, Adi, Fanous, Joseph, Gilon, Chaim, Hoffman, Amnon, Kessler, Horst

“…A highly systematic approach for the development of both orally bioavailable and bioactive cyclic N-methylated hexapeptides as high affinity ligands for the…”
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Oral aktive Peptide: Gibt es ein Patentrezept? by Räder, Andreas F B, Weinmüller, Michael, Reichart, Florian, Adi Schumacher‐Klinger, Merzbach, Shira, Gilon, Chaim, Hoffman, Amnon, Kessler, Horst

“…Die Entwicklung von Peptiden als potentielle Medikamente zielte über Jahrzehnte einzig darauf ab, höchste Affinitäten, Rezeptorselektivitäten oder Stabilität…”
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Lösung des Problems mangelnder oraler Verfügbarkeit cyclischer Hexapeptide: Entwicklung eines selektiven, oral verfügbaren Liganden für das Integrin αvβ3 by Weinmüller, Michael, Rechenmacher, Florian, Kiran Marelli, Udaya, Reichart, Florian, Kapp, Tobias G., Räder, Andreas F. B., Di Leva, Francesco Saverio, Marinelli, Luciana, Novellino, Ettore, Muñoz‐Félix, José M., Hodivala‐Dilke, Kairbaan, Schumacher, Adi, Fanous, Joseph, Gilon, Chaim, Hoffman, Amnon, Kessler, Horst

“…Ein systematischer Ansatz für die Entwicklung oral verfügbarer wie auch biologisch aktiver, cyclischer, N‐methylierter Hexapeptide als hoch affine Liganden für…”
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Myristoylation Confers Oral Bioavailability and Improves the Bioactivity of c(MyD 4–4), a Cyclic Peptide Inhibitor of MyD88 by Dishon, Shira, Schumacher-Klinger, Adi, Gilon, Chaim, Hoffman, Amnon, Nussbaum, Gabriel

“…Myeloid differentiation primary response 88 (MyD88) is an intracellular adaptor protein central to the signaling of multiple receptors involved in…”
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Neurotrophic factors and their receptors in lung development and implications in lung diseases by Rubin, Limor, Stabler, Collin T., Schumacher-Klinger, Adi, Marcinkiewicz, Cezary, Lelkes, Peter I., Lazarovici, Philip

“…[Display omitted] •Neurotrophic factors are expressed in epithelium, smooth muscle, vasculature, nerves and immune cells of the lung·•Neurotrophic factors are…”
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Lösung des Problems mangelnder oraler Verfugbarkeit cyclischer Hexapeptide: Entwicklung eines selektiven, oral verfugbaren Liganden fur das Integrin[alpha]v[beta]3 by Weinmuller, Michael, Rechenmacher, Florian, KiranMarelli, Udaya, Reichart, Florian, Kapp, Tobias G, Rader, Andreas F B, DiLeva, Francesco Saverio, Marinelli, Luciana, Novellino, Ettore, Munoz-Felix, José M, Hodivala-Dilke, Kairbaan, Schumacher, Adi, Fanous, Joseph, Gilon, Chaim, Hoffman, Amnon, Kessler, Horst

“…Ein systematischer Ansatz fur die Entwicklung oral verfugbarer wie auch biologisch aktiver, cyclischer, N-methylierter Hexapeptide als hoch affine Liganden fur…”
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Oral aktive Peptide: Gibt es ein Patentrezept? by Räder, Andreas F. B., Weinmüller, Michael, Reichart, Florian, Schumacher‐Klinger, Adi, Merzbach, Shira, Gilon, Chaim, Hoffman, Amnon, Kessler, Horst

“…Die Entwicklung von Peptiden als potentielle Medikamente zielte über Jahrzehnte einzig darauf ab, höchste Affinitäten, Rezeptorselektivitäten oder Stabilität…”
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