Search Results - "Schulze, P."

Lipid Use and Misuse by the Heart by Schulze, P Christian, Drosatos, Konstantinos, Goldberg, Ira J

“…The heart utilizes large amounts of fatty acids as energy providing substrates. The physiological balance of lipid uptake and oxidation prevents accumulation…”
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Lipid Metabolism and Toxicity in the Heart by Goldberg, Ira J., Trent, Chad M., Schulze, P. Christian

“…The heart has both the greatest caloric needs and the most robust oxidation of fatty acids (FAs). Under pathological conditions such as obesity and type 2…”
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Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock by Møller, Jacob E., Engstrøm, Thomas, Jensen, Lisette O., Eiskjær, Hans, Mangner, Norman, Polzin, Amin, Schulze, P. Christian, Skurk, Carsten, Nordbeck, Peter, Clemmensen, Peter, Panoulas, Vasileios, Zimmer, Sebastian, Schäfer, Andreas, Werner, Nikos, Frydland, Martin, Holmvang, Lene, Kjærgaard, Jesper, Sørensen, Rikke, Lønborg, Jacob, Lindholm, Matias G., Udesen, Nanna L.J., Junker, Anders, Schmidt, Henrik, Terkelsen, Christian J., Christensen, Steffen, Christiansen, Evald H., Linke, Axel, Woitek, Felix J., Westenfeld, Ralf, Möbius-Winkler, Sven, Wachtell, Kristian, Ravn, Hanne B., Lassen, Jens F., Boesgaard, Søren, Gerke, Oke, Hassager, Christian

“…In a randomized trial involving patients with STEMI and cardiogenic shock, mortality at 6 months was lower with mechanical circulatory support with a…”
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Effects of Early Empagliflozin Initiation on Diuresis and Kidney Function in Patients With Acute Decompensated Heart Failure (EMPAG-HF) by Schulze, P. Christian, Bogoviku, Jürgen, Westphal, Julian, Aftanski, Pawel, Haertel, Franz, Grund, Sissy, von Haehling, Stephan, Schumacher, Ulrike, Möbius-Winkler, Sven, Busch, Martin

“…Effective diuretic regimens using loop diuretics in patients with acute decompensated heart failure are often limited by the development of worsening kidney…”
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Lipotoxic very‐long‐chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes by Law, Brittany A., Liao, Xianghai, Moore, Kelsey S., Southard, Abigail, Roddy, Patrick, Ji, Ruiping, Szulc, Zdzislaw, Bielawska, Ala, Schulze, P. Christian, Cowart, L. Ashley

“…Accumulating data support a role for bioactive lipids as mediators of lipotixicity in cardiomyocytes. One class of these, the ceramides, constitutes a family…”
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Cardiac Metabolism in Heart Failure and Implications for Uremic Cardiomyopathy by Nguyen, T. Dung, Schulze, P. Christian

“…Chronic kidney disease is associated with an increased risk for the development and progression of cardiovascular disorders including hypertension,…”
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Cardiac Lipotoxicity: Molecular Pathways and Therapeutic Implications by Drosatos, Konstantinos, Schulze, P. Christian

“…Diabetes and obesity are both associated with lipotoxic cardiomyopathy exclusive of coronary artery disease and hypertension. Lipotoxicities have become a…”
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Efficacy of telemedical interventional management in patients with heart failure (TIM-HF2): a randomised, controlled, parallel-group, unmasked trial by Koehler, Friedrich, Koehler, Kerstin, Deckwart, Oliver, Prescher, Sandra, Wegscheider, Karl, Kirwan, Bridget-Anne, Winkler, Sebastian, Vettorazzi, Eik, Bruch, Leonhard, Oeff, Michael, Zugck, Christian, Doerr, Gesine, Naegele, Herbert, Störk, Stefan, Butter, Christian, Sechtem, Udo, Angermann, Christiane, Gola, Guntram, Prondzinsky, Roland, Edelmann, Frank, Spethmann, Sebastian, Schellong, Sebastian M, Schulze, P Christian, Bauersachs, Johann, Wellge, Brunhilde, Schoebel, Christoph, Tajsic, Milos, Dreger, Henryk, Anker, Stefan D, Stangl, Karl

“…Remote patient management in patients with heart failure might help to detect early signs and symptoms of cardiac decompensation, thus enabling a prompt…”
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Impact of treatment delay on mortality in ST-segment elevation myocardial infarction (STEMI) patients presenting with and without haemodynamic instability: results from the German prospective, multicentre FITT-STEMI trial by Scholz, Karl Heinrich, Maier, Sebastian K G, Maier, Lars S, Lengenfelder, Björn, Jacobshagen, Claudius, Jung, Jens, Fleischmann, Claus, Werner, Gerald S, Olbrich, Hans G, Ott, Rainer, Mudra, Harald, Seidl, Karlheinz, Schulze, P Christian, Weiss, Christian, Haimerl, Josef, Friede, Tim, Meyer, Thomas

“…Abstract Aims The aim of this study was to investigate the effect of contact-to-balloon time on mortality in ST-segment elevation myocardial infarction (STEMI)…”
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Blood-based microRNA signatures differentiate various forms of cardiac hypertrophy by Derda, Anselm A, Thum, Sabrina, Lorenzen, Johan M, Bavendiek, Udo, Heineke, Joerg, Keyser, Britta, Stuhrmann, Manfred, Givens, Raymond C, Kennel, Peter J, Christian Schulze, P, Widder, Julian D, Bauersachs, Johann, Thum, Thomas

“…Abstract Background Hypertrophic cardiomyopathy (HCM) is caused by mutations in different structural genes and induces pathological hypertrophy with sudden…”
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The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial by Voors, Adriaan A., Angermann, Christiane E., Teerlink, John R., Collins, Sean P., Kosiborod, Mikhail, Biegus, Jan, Ferreira, João Pedro, Nassif, Michael E., Psotka, Mitchell A., Tromp, Jasper, Borleffs, C. Jan Willem, Ma, Changsheng, Comin-Colet, Joseph, Fu, Michael, Janssens, Stefan P., Kiss, Robert G., Mentz, Robert J., Sakata, Yasushi, Schirmer, Henrik, Schou, Morten, Schulze, P. Christian, Spinarova, Lenka, Volterrani, Maurizio, Wranicz, Jerzy K., Zeymer, Uwe, Zieroth, Shelley, Brueckmann, Martina, Blatchford, Jonathan P., Salsali, Afshin, Ponikowski, Piotr

“…The sodium–glucose cotransporter 2 inhibitor empagliflozin reduces the risk of cardiovascular death or heart failure hospitalization in patients with chronic…”
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Phytosterols and Cardiovascular Disease by Makhmudova, Umidakhon, Schulze, P. Christian, Lütjohann, Dieter, Weingärtner, Oliver

“…Purpose of Review Coronary heart disease is the leading cause of mortality worldwide. Elevated blood cholesterol levels are not only the major but also the…”
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Impella Support for Acute Myocardial Infarction Complicated by Cardiogenic Shock: Matched-Pair IABP-SHOCK II Trial 30-Day Mortality Analysis by Schrage, Benedikt, Ibrahim, Karim, Loehn, Tobias, Werner, Nikos, Sinning, Jan-Malte, Pappalardo, Federico, Pieri, Marina, Skurk, Carsten, Lauten, Alexander, Landmesser, Ulf, Westenfeld, Ralf, Horn, Patrick, Pauschinger, Matthias, Eckner, Dennis, Twerenbold, Raphael, Nordbeck, Peter, Salinger, Tim, Abel, Peter, Empen, Klaus, Busch, Mathias C, Felix, Stephan B, Sieweke, Jan-Thorben, Møller, Jacob Eifer, Pareek, Nilesh, Hill, Jonathan, MacCarthy, Philip, Bergmann, Martin W, Henriques, José P.S, Möbius-Winkler, Sven, Schulze, P Christian, Ouarrak, Taoufik, Zeymer, Uwe, Schneider, Steffen, Blankenberg, Stefan, Thiele, Holger, Schäfer, Andreas, Westermann, Dirk

“…BACKGROUND:Percutaneous mechanical circulatory support devices are increasingly used in acute myocardial infarction complicated by cardiogenic shock (AMI-CS),…”
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Prognostic relevance of serum lactate kinetics in critically ill patients by Masyuk, Maryna, Wernly, Bernhard, Lichtenauer, Michael, Franz, Marcus, Kabisch, Bjoern, Muessig, Johanna M., Zimmermann, Georg, Lauten, Alexander, Schulze, P. Christian, Hoppe, Uta C., Kelm, Malte, Bakker, Jan, Jung, Christian

“…Purpose Changes of lactate concentration over time were reported to be associated with survival in septic patients. We aimed to evaluate delta-lactate (ΔLac)…”
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Left Ventricular Unloading Is Associated With Lower Mortality in Patients With Cardiogenic Shock Treated With Venoarterial Extracorporeal Membrane Oxygenation: Results From an International, Multicenter Cohort Study by Schrage, Benedikt, Becher, Peter Moritz, Bernhardt, Alexander, Bezerra, Hiram, Blankenberg, Stefan, Brunner, Stefan, Colson, Pascal, Cudemus Deseda, Gaston, Dabboura, Salim, Eckner, Dennis, Eden, Matthias, Eitel, Ingo, Frank, Derk, Frey, Norbert, Funamoto, Masaki, Goßling, Alina, Graf, Tobias, Hagl, Christian, Kirchhof, Paulus, Kupka, Danny, Landmesser, Ulf, Lipinski, Jerry, Lopes, Mathew, Majunke, Nicolas, Maniuc, Octavian, McGrath, Daniel, Möbius-Winkler, Sven, Morrow, David A., Mourad, Marc, Noel, Curt, Nordbeck, Peter, Orban, Martin, Pappalardo, Federico, Patel, Sandeep M., Pauschinger, Matthias, Pazzanese, Vittorio, Reichenspurner, Hermann, Sandri, Marcus, Schulze, P. Christian, H.G. Schwinger, Robert, Sinning, Jan-Malte, Aksoy, Adem, Skurk, Carsten, Szczanowicz, Lukasz, Thiele, Holger, Tietz, Franziska, Varshney, Anubodh, Wechsler, Lukas, Westermann, Dirk

“…Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used to treat cardiogenic shock. However, VA-ECMO might hamper myocardial recovery…”
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Impact of COVID-19 outbreak on regional STEMI care in Germany by Scholz, Karl Heinrich, Lengenfelder, Björn, Thilo, Christian, Jeron, Andreas, Stefanow, Stefan, Janssens, Uwe, Bauersachs, Johann, Schulze, P. Christian, Winter, Klaus Dieter, Schröder, Jörg, vom Dahl, Jürgen, von Beckerath, Nicolas, Seidl, Karlheinz, Friede, Tim, Meyer, Thomas

“…Aims To assess the impact of the lockdown due to coronavirus disease 2019 (COVID-19) on key quality indicators for the treatment of ST-segment elevation…”
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Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers by Akat, Kemal Marc, Moore-McGriff, D'Vesharronne, Morozov, Pavel, Brown, Miguel, Gogakos, Tasos, Da Rosa, Joel Correa, Mihailovic, Aleksandra, Sauer, Markus, Ji, Ruiping, Ramarathnam, Aarthi, Totary-Jain, Hana, Williams, Zev, Tuschl, Thomas, Schulze, P. Christian

“…Heart failure (HF) is associated with high morbidity and mortality and its incidence is increasing worldwide. MicroRNAs (miRNAs) are potential markers and…”
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Motion correction in MRI of the brain by Godenschweger, F, Kägebein, U, Stucht, D, Yarach, U, Sciarra, A, Yakupov, R, Lüsebrink, F, Schulze, P, Speck, O

“…Subject motion in MRI is a relevant problem in the daily clinical routine as well as in scientific studies. Since the beginning of clinical use of MRI, many…”
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Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis by Liao, Xudong, Zhang, Rongli, Lu, Yuan, Prosdocimo, Domenick A, Sangwung, Panjamaporn, Zhang, Lilei, Zhou, Guangjin, Anand, Puneet, Lai, Ling, Leone, Teresa C, Fujioka, Hisashi, Ye, Fang, Rosca, Mariana G, Hoppel, Charles L, Schulze, P Christian, Abel, E Dale, Stamler, Jonathan S, Kelly, Daniel P, Jain, Mukesh K

“…Mitochondrial homeostasis is critical for tissue health, and mitochondrial dysfunction contributes to numerous diseases, including heart failure. Here, we have…”
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Ventricular Assist Device Implantation Corrects Myocardial Lipotoxicity, Reverses Insulin Resistance, and Normalizes Cardiac Metabolism in Patients With Advanced Heart Failure by CHOKSHI, Aalap, DROSATOS, Konstantinos, MILTING, Hendrik, CHUNG, Christine S, JORDE, Ulrich, NAKA, Yoshifumi, MANCINI, Donna M, GOLDBERG, Ira J, CHRISTIAN SCHULZE, P, CHEEMA, Faisal H, RUIPING JI, KHAWAJA, Tuba, SHUIQING YU, KATO, Tomoko, KHAN, Raffay, TAKAYAMA, Hiroo, KNOLL, Ralph

“…Heart failure is associated with impaired myocardial metabolism with a shift from fatty acids to glucose use for ATP generation. We hypothesized that cardiac…”
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