Search Results - "Schulze, Costas"

Prediction and risk stratification of survival in accidental hypothermia requiring extracorporeal life support: An individual patient data meta-analysis by Saczkowski, Richard S., Brown, Doug J.A., Abu-Laban, Riyad B., Fradet, Guy, Schulze, Costas J., Kuzak, Nick D.

“…Extra-corporeal life support (ECLS) is a life-saving intervention for patients with hypothermia induced cardiac arrest or severe cardiovascular instability…”
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Difference between pre-operative and cardiopulmonary bypass mean arterial pressure is independently associated with early cardiac surgery-associated acute kidney injury by Kanji, Hussein D, Schulze, Costas J, Hervas-Malo, Marilou, Wang, Peter, Ross, David B, Zibdawi, Mohamad, Bagshaw, Sean M

“…Cardiac surgery-associated acute kidney injury (CSA-AKI) contributes to increased morbidity and mortality. However, its pathophysiology remains incompletely…”
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Intracellular action of matrix metalloproteinase-2 accounts for acute myocardial ischemia and reperfusion injury by WENJIE WANG, SCHULZE, Costas J, SUAREZ-PINZON, Wilma L, DYCK, Jason R. B, SAWICKI, Grzegorz, SCHULZ, Richard

“…Matrix metalloproteinases are best recognized for their ability to degrade the extracellular matrix in both physiological and pathological conditions. However,…”
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Degradation of myosin light chain in isolated rat hearts subjected to ischemia-reperfusion injury : A new intracellular target for matrix metalloproteinase-2 by SAWICKI, Grzegorz, LEON, Hernando, SAWICKA, Jolanta, SARIAHMETOGLU, Meltem, SCHULZE, Costas J, SCOTT, Paul G, SZCZESNA-CORDARY, Danuta, SCHULZ, Richard

“…Matrix metalloproteinase-2 (MMP-2) contributes to cardiac dysfunction resulting from ischemia-reperfusion (I/R) injury. MMP-2 not only remodels the…”
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Matrix metalloproteinase‐2 (MMP‐2) is present in the nucleus of cardiac myocytes and is capable of cleaving poly (ADP‐ribose) polymerase (PARP) in vitro by Kwan, Jennifer A., Schulze, Costas J., Wang, Wenjie, Leon, Hernando, Sariahmetoglu, Meltem, Sung, Miranda, Sawicka, Jolanta, Sims, David E., Sawicki, Grzegorz, Schulz, Richard

“…Matrix metalloproteinases (MMPs) are traditionally known for their role in extracellular matrix remodeling. Increasing evidence reveals several alternative…”
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Ischaemia–reperfusion injury activates matrix metalloproteinases in the human heart by Lalu, Manoj M., Pasini, Evasio, Schulze, Costas J., Ferrari-Vivaldi, Mario, Ferrari-Vivaldi, Gianna, Bachetti, Tiziana, Schulz, Richard

“…Aims Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) regulate matrix remodelling in the heart and play a pivotal role in…”
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Doxycycline Reduces Cardiac Matrix Metalloproteinase-2 Activity but Does not Ameliorate Myocardial Dysfunction During Reperfusion in Coronary Artery Bypass Patients Undergoing Cardiopulmonary Bypass by Schulze, Costas J, Castro, Michele M, Kandasamy, Arulmozhi D, Cena, Jonathan, Bryden, Courtney, Wang, Shoa H, Koshal, Arvind, Tsuyuki, Ross T, Finegan, Barry A, Schulz, Richard

“…OBJECTIVES:Matrix metalloproteinase-2 proteolyzes intracellular proteins in the heart and induces acute myocardial contractile dysfunction in…”
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Imbalance between tissue inhibitor of metalloproteinase-4 and matrix metalloproteinases during acute myocardial ischemia-reperfusion injury by SCHULZE, Costas J, WENJIE WANG, SUAREZ-PINZON, Wilma L, SAWICKA, Jolanta, SAWICKI, Grzegorz, SCHULZ, Richard

“…We have previously reported that matrix metalloproteinase-2 (MMP-2) contributes to myocardial ischemia-reperfusion injury by degradation of troponin I, a…”
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Phosphorylcholine-Coated Circuits Improve Preservation of Platelet Count and Reduce Expression of Proinflammatory Cytokines in CABG: A Prospective Randomized Trial by Schulze, Costas J., Han, Lin, Ghorpade, Nitin, Etches, Wai S., Stang, Linda, Koshal, Arvind, Wang, Shao Hua

“…Background: The interaction of blood with foreign artificial surfaces during cardiopulmonary bypass (CPB) has been recognized as a major stimulus in evoking a…”
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Heart transplantation: an approach to treating primary cardiac sarcoma? by Uberfuhr, Peter, Meiser, Bruno, Fuchs, Alexandra, Schulze, Costas, Reichenspurner, Hermann, Falk, Martin, Weiss, Max, Wintersperger, Bernd, Issels, Rolf, Reichart, Bruno

“…Treating rare, primary cardiac soft-tissue sarcomas (C-STS) with heart transplantation (HTx) is controversial. Conventional tumor resection only partially…”
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Extracorporeal life support rewarming rate is associated with survival with good neurological outcome in accidental hypothermia by Saczkowski, Richard, Kuzak, Nick, Grunau, Brian, Schulze, Costas

“…Abstract OBJECTIVES Favourable outcomes have been demonstrated after extracorporeal life support (ECLS) facilitated rewarming for severe accidental…”
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Imbalance Between Tissue Inhibitor of Metalloproteinase-4 and Matrix Metalloproteinases During Acute Myoctardial Ischemia-Reperfusion Injury by Schulze, Costas J., Wang, Wenjie, Suarez-Pinzon, Wilma L., Sawicka, Jolanta, Sawicki, Grzegorz, Schulz, Richard

“…Background— We have previously reported that matrix metalloproteinase-2 (MMP-2) contributes to myocardial ischemia-reperfusion injury by degradation of…”
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Enhanced NO and superoxide generation in dysfunctional hearts from endotoxemic rats by Khadour, Fadi H, Panas, Donna, Ferdinandy, Péter, Schulze, Costas, Csont, Tamás, Lalu, Manoj M, Wildhirt, Stephen M, Schulz, Richard

“…Free radicals have been implicated in the etiology of cardiac dysfunction during sepsis, but the actual species responsible remains unclear. We studied the…”
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Off-pump epicardial tissue sealing—a novel method for atrioventricular disruption complicating mitral valve procedures by Schuetz, Albert, Schulze, Costas, Wildhirt, Stephen M

“…Atrioventricular disruption (AVD) is a rare (1%–2%) but fatal complication after mitral valve procedures; the intraoperative mortality is more than 50% despite…”
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Inducible nitric oxide synthase activation after ischemia/reperfusion contributes to myocardial dysfunction and extent of infarct size in rabbits: evidence for a late phase of nitric oxide-mediated reperfusion injury by Wildhirt, S M, Weismueller, S, Schulze, C, Conrad, N, Kornberg, A, Reichart, B

“…Ischemia/reperfusion (I/R) leads to the induction of inducible nitric oxide synthase. The present study investigated the effects of selective and continuous…”
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Off-pump epicardial tissue sealing: A novel method for atrioventricular disruption complicating mitral valve procedures. Commentary by SCHUETZ, Albert, SCHULZE, Costas, WILDHIRT, Stephen M, ESPOSITO, Rick A

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Three-dimensional video and robot-assisted port-access mitral valve operation by Reichenspurner, H, Boehm, D H, Gulbins, H, Schulze, C, Wildhirt, S, Welz, A, Detter, C, Reichart, B

“…In order to minimize surgical trauma, video-assisted mitral valve operation has been started using the Port-Access technique with the addition of a…”
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Inhibition of inducible nitric oxide synthase and superoxide production reduces matrix metalloproteinase-9 activity and restores coronary vasomotor function in rat cardiac allografts by Egi, Koso, Conrad, Nicole E., Kwan, Jennifer, Schulze, Costas, Schulz, Richard, Wildhirt, Stephen M.

“…Objective: Oxidants such as nitric oxide (NO) and superoxide are involved in coronary endothelial dysfunction, an early event in the process of allograft…”
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Persistently increased systemic, but not cardiac-specific, adhesion molecule expression and coronary endothelial dysfunction in human cardiac allografts by Wildhirt, Stephen M., Schulze, Costas, Conrad, Nicole, Bauernschmitt, Robert, Lange, Rüdiger, von Scheidt, Wolfgang

“…Adhesion molecules are involved in inflammatory processes that alter endothelial function and lead to impairment of coronary vasomotor function. We studied a…”
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Reduction of systemic and cardiac adhesion molecule expression after off-pump versus conventional coronary artery bypass grafting by Wildhirt, S M, Schulze, C, Schulz, C, Egi, K, Brenner, P, Mair, H, Schütz, A, Reichart, B

“…Cardiopulmonary bypass (CPB) and operative trauma are associated with increased expression of proinflammatory mediators. We determined the relative…”
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