Search Results - "Schulz‐Knappe, Peter"

Comprehensive Longitudinal Surveillance of the IgG Autoantibody Repertoire in Established Systemic Lupus Erythematosus by Vordenbäumen, Stefan, Brinks, Ralph, Hoyer, Annika, Fischer‐Betz, Rebecca, Pongratz, Georg, Lowin, Torsten, Zucht, Hans‐Dieter, Budde, Petra, Bleck, Ellen, Schulz‐Knappe, Peter, Schneider, Matthias

“…Objective To investigate the role of epitope spreading in established systemic lupus erythematosus (SLE). Methods IgG autoantibody reactivity with 398 distinct…”
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Peptidomic analysis of human blood specimens: Comparison between plasma specimens and serum by differential peptide display by Tammen, Harald, Schulte, Imke, Hess, Rudiger, Menzel, Christoph, Kellmann, Markus, Mohring, Thomas, Schulz-Knappe, Peter

“…The human Plasma Proteome Project pilot phase aims to analyze serum and plasma specimens to elucidate specimen characteristics by various proteomic techniques…”
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HUPO Plasma Proteome Project specimen collection and handling: Towards the standardization of parameters for plasma proteome samples by Rai, Alex J., Gelfand, Craig A., Haywood, Bruce C., Warunek, David J., Yi, Jizu, Schuchard, Mark D., Mehigh, Richard J., Cockrill, Steven L., Scott, Graham B. I., Tammen, Harald, Schulz-Knappe, Peter, Speicher, David W., Vitzthum, Frank, Haab, Brian B., Siest, Gerard, Chan, Daniel W.

“…There is a substantial list of pre‐analytical variables that can alter the analysis of blood‐derived samples. We have undertaken studies on some of these…”
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Serum-autoantibodies for discovery of prostate cancer specific biomarkers by Massoner, Petra, Lueking, Angelika, Goehler, Heike, Höpfner, Annabel, Kowald, Axel, Kugler, Karl G., Amersdorfer, Peter, Horninger, Wolfgang, Bartsch, Georg, Schulz-Knappe, Peter, Klocker, Helmut

“…BACKGROUND The currently used prostate cancer serum marker has a low cancer specificity and improved diagnostics are needed. Here we evaluated whether…”
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Isolation and biochemical characterization of LEAP‐2, a novel blood peptide expressed in the liver by Krause, Alexander, Sillard, Rannar, Kleemeier, Burkhard, Klüver, Enno, Maronde, Erik, Conejo‐García, José Ramon, Forssmann, Wolf Georg, Schulz‐Knappe, Peter, Nehls, Michael C., Wattler, Frank, Wattler, Sigrid, Adermann, Knut

“…The human genome contains numerous genes whose protein products are unknown in terms of structure, interaction partner, expression, and function. To unravel…”
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A functional annotation of subproteomes in human plasma by Ping, Peipei, Vondriska, Thomas M., Creighton, Chad J., Gandhi, TKB, Yang, Ziping, Menon, Rajasree, Kwon, Min-Seok, Cho, Sang Yun, Drwal, Garry, Kellmann, Markus, Peri, Suraj, Suresh, Shubha, Gronborg, Mads, Molina, Henrik, Chaerkady, Raghothama, Rekha, B., Shet, Arun S., Gerszten, Robert E., Wu, Haifeng, Raftery, Mark, Wasinger, Valerie, Schulz-Knappe, Peter, Hanash, Samir M., Paik, Young-ki, Hancock, William S., States, David J., Omenn, Gilbert S., Pandey, Akhilesh

“…The data collected by Human Proteome Organization's Plasma Proteome Pilot project phase was analyzed by members of our working group. Accordingly, a functional…”
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Historical perspective of peptidomics by Schrader, Michael, Schulz-Knappe, Peter, Fricker, Lloyd D.

“…•Peptidomics is the analysis of peptides, without focusing on biological activity.•Developments in HPLC and MS are the basis of its analytical…”
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Profiling of IgG antibodies targeting unmodified and corresponding citrullinated autoantigens in a multicenter national cohort of early arthritis in Germany by Vordenbäumen, Stefan, Brinks, Ralph, Schriek, Patrick, Lueking, Angelika, Richter, Jutta G, Budde, Petra, Schulz-Knappe, Peter, Zucht, Hans-Dieter, Callhoff, Johanna, Schneider, Matthias

“…Abstract Objective To assess the diagnostic potential of IgG antibodies to citrullinated and corresponding native autoantigens in early arthritis. Methods IgG…”
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Multivariate binary classification of imbalanced datasets—A case study based on high‐dimensional multiplex autoimmune assay data by Schlieker, Laura, Telaar, Anna, Lueking, Angelika, Schulz‐Knappe, Peter, Theek, Carmen, Ickstadt, Katja

“…The classification of a population by a specific trait is a major task in medicine, for example when in a diagnostic setting groups of patients with specific…”
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LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity by Krause, Alexander, Neitz, Susanne, Mägert, Hans-Jürgen, Schulz, Axel, Forssmann, Wolf-Georg, Schulz-Knappe, Peter, Adermann, Knut

“…We report the isolation and characterization of a novel human peptide with antimicrobial activity, termed LEAP-1 (liver-expressed antimicrobial peptide). Using…”
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Serum Autoantibodies in Chronic Prostate Inflammation in Prostate Cancer Patients by Schlick, Bettina, Massoner, Petra, Lueking, Angelika, Charoentong, Pornpimol, Blattner, Mirjam, Schaefer, Georg, Marquart, Klaus, Theek, Carmen, Amersdorfer, Peter, Zielinski, Dirk, Kirchner, Matthias, Trajanoski, Zlatko, Rubin, Mark A, Müllner, Stefan, Schulz-Knappe, Peter, Klocker, Helmut

“…Chronic inflammation is frequently observed on histological analysis of malignant and non-malignant prostate specimens. It is a suspected supporting factor for…”
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In vivo profiling of DPP4 inhibitors reveals alterations in collagen metabolism and accumulation of an amyloid peptide in rat plasma by Jost, Marco M., Lamerz, Jens, Tammen, Harald, Menzel, Christoph, De Meester, Ingrid, Lambeir, Anne-Marie, Augustyns, Koen, Scharpé, Simon, Zucht, Hans Dieter, Rose, Horst, Jürgens, Michael, Schulz-Knappe, Peter, Budde, Petra

“…Dipeptidyl peptidase 4 (DPP4) inhibitors represent a novel class of oral anti-hyperglycemic agents. The complete pharmacological profile of these protease…”
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The peptidomics concept by Schulz-Knappe, Peter, Schrader, Michael, Zucht, Hans-Dieter

“…Peptides are a paramount example of how nature diversifies from one single gene to release multiple, regulated functionalities at the desired sites and time…”
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Candidate verification of iron-regulated Neisseria meningitidis proteins using isotopic versions of tandem mass tags (TMT) and single reaction monitoring by Byers, Helen L., Campbell, James, van Ulsen, Peter, Tommassen, Jan, Ward, Malcolm A., Schulz-Knappe, Peter, Prinz, Thorsten, Kuhn, Karsten

“…Tandem Mass Tags (TMT) are suited to both global and targeted quantitation approaches of proteins and peptides. Different versions of these tags allow for the…”
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Effects of various phosphodiesterase-inhibitors, forskolin, and sodium nitroprusside on porcine detrusor smooth muscle tonic responses to muscarinergic stimulation and cyclic nucleotide levels in vitro by Truss, Michael C., Ückert, Stefan, Stief, Christian G., Kuczyk, Markus, Schulz-Knappe, Peter, Forssmann, Wolf-Georg, Jonas, Udo

“…The cyclic nucleotides cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) are second messengers involved in the regulation of…”
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Correlation-associated peptide networks of human cerebrospinal fluid by Lamerz, Jens, Selle, Hartmut, Scapozza, Leonardo, Crameri, Reto, Schulz-Knappe, Peter, Mohring, Thomas, Kellmann, Markus, Khamenia, Valeri, Zucht, Hans-Dieter

“…Profiling of peptides and small proteins from either human body fluids or tissues by chromatography and subsequent mass spectrometry reveals several thousand…”
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Prerequisites for peptidomic analysis of blood samples: I. Evaluation of blood specimen qualities and determination of technical performance characteristics by Tammen, Harald, Schulte, Imke, Hess, Rüdiger, Menzel, Christoph, Kellmann, Markus, Schulz-Knappe, Peter

“…Proteomics studies aiming at a detailed analysis of proteins, and peptidomics, aiming at the analysis of the low molecular weight proteome (peptidome) offer a…”
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Expression profiling of breast cancer cells by differential peptide display by TAMMEN, Harald, KREIPE, Hans, HESS, Rüdiger, KELLMANN, Markus, LEHMANN, Ulrich, PICH, Andreas, LAMPING, Norbert, SCHULZ-KNAPPE, Peter, ZUCHT, Hans-Dieter, LILISCHKIS, Richard

“…Expression profiling of RNAs or proteins has become a promising means to investigate the heterogeneity of histopathologically defined classes of cancer…”
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HCC-2, a Human Chemokine: Gene Structure, Expression Pattern, and Biological Activity by Pardigol, Andreas, Forssmann, Ulf, Zucht, Hans-Dieter, Loetscher, Pius, Schulz-Knappe, Peter, Baggiolini, Marco, Forssmann, Wolf-Georg, Magert, Hans-Jurgen

“…Cloning and sequencing of the upstream region of the gene of the CC chemokine HCC-1 led to the discovery of an adjacent gene coding for a CC chemokine that was…”
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High-throughput biomarker discovery and identification by mass spectrometry by Menzel, Christoph, Guillou, Vincent, Kellmann, Markus, Khamenya, Valery, Juergens, Michael, Schulz-Knappe, Peter

“…Native peptides and proteins are of increasing interest in biomedical research because they hold promise to represent a large number of useful diagnostic and…”
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