Search Results - "Schultz, Tracey L"

Translation initiation factor eIF1.2 promotes Toxoplasma stage conversion by regulating levels of key differentiation factors by Wang, Fengrong, Holmes, Michael J., Hong, Hea Jin, Thaprawat, Pariyamon, Kannan, Geetha, Huynh, My-Hang, Schultz, Tracey L., Licon, M. Haley, Lourido, Sebastian, Dong, Wenzhao, Brito Querido, Jailson, Sullivan, William J., O’Leary, Seán E., Carruthers, Vern B.

“…The parasite Toxoplasma gondii persists in its hosts by converting from replicating tachyzoites to latent bradyzoites housed in tissue cysts. The molecular…”
Get full text

Toxoplasma TgATG9 is critical for autophagy and long-term persistence in tissue cysts by Smith, David, Kannan, Geetha, Coppens, Isabelle, Wang, Fengrong, Nguyen, Hoa Mai, Cerutti, Aude, Olafsson, Einar B, Rimple, Patrick A, Schultz, Tracey L, Mercado Soto, Nayanna M, Di Cristina, Manlio, Besteiro, Sébastien, Carruthers, Vern B

“…Many of the world's warm-blooded species are chronically infected with tissue cysts, including an estimated one-third of the global human population. The…”
Get full text

Type I interferon governs immunometabolic checkpoints that coordinate inflammation during Staphylococcal infection by Reynolds, Mack B., Klein, Benjamin, McFadden, Michael J., Judge, Norah K., Navarrete, Hannah E., Michmerhuizen, Britton C, Awad, Dominik, Schultz, Tracey L., Harms, Paul W., Zhang, Li, O’Meara, Teresa R., Sexton, Jonathan Z., Lyssiotis, Costas A., Kahlenberg, J. Michelle, O’Riordan, Mary X.

“…Macrophage metabolic plasticity is central to inflammatory programming, yet mechanisms of coordinating metabolic and inflammatory programs during infection are…”
Get full text

Acquisition of Host Cytosolic Protein by Toxoplasma gondii Bradyzoites by Kannan, Geetha, Thaprawat, Pariyamon, Schultz, Tracey L, Carruthers, Vern B

“…is a protozoan parasite that persists in the central nervous system as intracellular chronic-stage bradyzoites that are encapsulated by a thick cyst wall…”
Get full text

Mitochondria-Derived Vesicles Deliver Antimicrobial Reactive Oxygen Species to Control Phagosome-Localized Staphylococcus aureus by Abuaita, Basel H., Schultz, Tracey L., O’Riordan, Mary X.

“…Pathogenic bacteria taken up into the macrophage phagosome are the target of many anti-microbial mechanisms. Although mitochondria-derived antimicrobial…”
Get full text

The IRE1α Stress Signaling Axis Is a Key Regulator of Neutrophil Antimicrobial Effector Function by Abuaita, Basel H, Sule, Gautam J, Schultz, Tracey L, Gao, Fushan, Knight, Jason S, O'Riordan, Mary X

“…Activation of the endoplasmic reticulum stress sensor, IRE1α, is required for effective immune responses against bacterial infection and is associated with…”
Get full text

Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis by Vidadala, Rama Subba Rao, Rivas, Kasey L, Ojo, Kayode K, Hulverson, Matthew A, Zambriski, Jennifer A, Bruzual, Igor, Schultz, Tracey L, Huang, Wenlin, Zhang, Zhongsheng, Scheele, Suzanne, DeRocher, Amy E, Choi, Ryan, Barrett, Lynn K, Siddaramaiah, Latha Kallur, Hol, Wim G. J, Fan, Erkang, Merritt, Ethan A, Parsons, Marilyn, Freiberg, Gail, Marsh, Kennan, Kempf, Dale J, Carruthers, Vern B, Isoherranen, Nina, Doggett, J. Stone, Van Voorhis, Wesley C, Maly, Dustin J

“…New therapies are needed for the treatment of toxoplasmosis, which is a disease caused by the protozoan parasite Toxoplasma gondii. To this end, we previously…”
Get full text

Cerebral complement C1q activation in chronic Toxoplasma infection by Xiao, Jianchun, Li, Ye, Gressitt, Kristin L, He, Helen, Kannan, Geetha, Schultz, Tracey L, Svezhova, Nadezhda, Carruthers, Vern B, Pletnikov, Mikhail V, Yolken, Robert H, Severance, Emily G

“…Highlights • Complement activation and exposure to Toxoplasma are risk factors for schizophrenia. • Here, Toxoplasma infection in mice caused elevated brain…”
Get full text

Shared Immune and Repair Markers During Experimental Toxoplasma Chronic Brain Infection and Schizophrenia by Tomasik, Jakub, Schultz, Tracey L, Kluge, Wolfgang, Yolken, Robert H, Bahn, Sabine, Carruthers, Vern B

“…Chronic neurologic infection with Toxoplasma gondii is relatively common in humans and is one of the strongest known risk factors for schizophrenia…”
Get full text

Role of Toxoplasma gondii Chloroquine Resistance Transporter in Bradyzoite Viability and Digestive Vacuole Maintenance by Kannan, Geetha, Di Cristina, Manlio, Schultz, Aric J, Huynh, My-Hang, Wang, Fengrong, Schultz, Tracey L, Lunghi, Matteo, Coppens, Isabelle, Carruthers, Vern B

“…is a ubiquitous pathogen that can cause encephalitis, congenital defects, and ocular disease. has also been implicated as a risk factor for mental illness in…”
Get full text

A Toxoplasma gondii putative amino acid transporter localizes to the plant-like vacuolar compartment and controls parasite extracellular survival and stage differentiation by Piro, Federica, Masci, Silvia, Kannan, Geetha, Focaia, Riccardo, Schultz, Tracey L, Thaprawat, Pariyamon, Carruthers, Vern B, Di Cristina, Manlio

“…is a protozoan parasite that infects a broad spectrum of hosts and can colonize many organs and cell types. The ability to reside within a wide range of…”
Get full text

A Thiazole Derivative of Artemisinin Moderately Reduces Toxoplasma gondii Cyst Burden in Infected Mice by Schultz, Tracey L, Hencken, Christopher P, Woodard, Lauren E, Posner, Gary H, Yolken, Robert H, Jones-Brando, Lorraine, Carruthers, Vern B

“…Toxoplasmosis continues to be a public health problem, causing significant morbidity worldwide. Currently available medications, effective for acute…”
Get full text

Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection by Di Cristina, Manlio, Dou, Zhicheng, Lunghi, Matteo, Kannan, Geetha, Huynh, My-Hang, McGovern, Olivia L., Schultz, Tracey L., Schultz, Aric J., Miller, Alyssa J., Hayes, Beth M., van der Linden, Wouter, Emiliani, Carla, Bogyo, Matthew, Besteiro, Sébastien, Coppens, Isabelle, Carruthers, Vern B.

“…Globally, nearly 2 billion people are infected with the intracellular protozoan Toxoplasma gondii 1 . This persistent infection can cause severe disease in…”
Get full text

Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection by Di Cristina, Manlio, Dou, Zhicheng, Lunghi, Matteo, Kannan, Geetha, Huynh, My-Hang, McGovern, Olivia L., Schultz, Tracey L., Schultz, Aric J., Miller, Alyssa J., Hayes, Beth M., van der Linden, Wouter, Emiliani, Carla, Bogyo, Matthew, Besteiro, Sébastien, Coppens, Isabelle, Carruthers, Vern B.

Get full text

Role of italic toggle="yes">Toxoplasma gondii /italic> Chloroquine Resistance Transporter in Bradyzoite Viability and Digestive Vacuole Maintenance by Geetha Kannan, Manlio Di Cristina, Aric J. Schultz, My-Hang Huynh, Fengrong Wang, Tracey L. Schultz, Matteo Lunghi, Isabelle Coppens, Vern B. Carruthers

“…ABSTRACT Toxoplasma gondii is a ubiquitous pathogen that can cause encephalitis, congenital defects, and ocular disease. T. gondii has also been implicated as…”
Get full text