Search Results - "Schultz, Peter G."

Adding new chemistries to the genetic code by Liu, Chang C, Schultz, Peter G

“…The development of new orthogonal aminoacyl-tRNA synthetase/tRNA pairs has led to the addition of approximately 70 unnatural amino acids (UAAs) to the genetic…”
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At the Interface of Chemical and Biological Synthesis: An Expanded Genetic Code by Xiao, Han, Schultz, Peter G

“…The ability to site-specifically incorporate noncanonical amino acids (ncAAs) with novel structures into proteins in living cells affords a powerful tool to…”
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Mechanistic studies of a small-molecule modulator of SMN2 splicing by Wang, Jingxin, Schultz, Peter G., Johnson, Kristen A.

“…RG-7916 is a first-in-class drug candidate for the treatment of spinal muscular atrophy (SMA) that functions by modulating pre-mRNA splicing of the SMN2 gene,…”
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Beyond the Canonical 20 Amino Acids: Expanding the Genetic Lexicon by Young, Travis S., Schultz, Peter G.

“…The ability to genetically encode unnatural amino acids beyond the common 20 has allowed unprecedented control over the chemical structures of recombinantly…”
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A Genetically Encoded Fluorescent Probe in Mammalian Cells by Chatterjee, Abhishek, Guo, Jiantao, Lee, Hyun Soo, Schultz, Peter G

“…Fluorescent reporters are useful in vitro and in vivo probes of protein structure, function, and localization. Here we report that the fluorescent amino acid,…”
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A chemical toolkit for proteins - an expanded genetic code by Schultz, Peter G, Xie, Jianming

“…Recently, a method to encode unnatural amino acids with diverse physicochemical and biological properties genetically in bacteria, yeast and mammalian cells…”
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Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies by Rodgers, David T., Mazagova, Magdalena, Hampton, Eric N., Cao, Yu, Ramadoss, Nitya S., Hardy, Ian R., Schulman, Andrew, Du, Juanjuan, Wang, Feng, Singer, Oded, Ma, Jennifer, Nunez, Vanessa, Shen, Jiayin, Woods, Ashley K., Wright, Timothy M., Schultz, Peter G., Kim, Chan Hyuk, Young, Travis S.

“…Chimeric antigen receptor T (CAR-T) cell therapy has produced impressive results in clinical trials for B-cell malignancies. However, safety concerns related…”
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Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis by Harbut, Michael B., Vilchèze, Catherine, Luo, Xiaozhou, Hensler, Mary E., Guo, Hui, Yang, Baiyuan, Chatterjee, Arnab K., Nizet, Victor, Jacobs, William R., Schultz, Peter G., Wang, Feng

“…Infections caused by antibiotic-resistant bacteria are a rising public health threat and make the identification of new antibiotics a priority. From a…”
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Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites by Wikoff, William R, Anfora, Andrew T, Liu, Jun, Schultz, Peter G, Lesley, Scott A, Peters, Eric C, Siuzdak, Gary

“…Although it has long been recognized that the enteric community of bacteria that inhabit the human distal intestinal track broadly impacts human health, the…”
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A Stem Cell-Based Approach to Cartilage Repair by Johnson, Kristen, Zhu, Shoutian, Tremblay, Matthew S., Payette, Joshua N., Wang, Jianing, Bouchez, Laure C., Meeusen, Shelly, Althage, Alana, Cho, Charles Y., Wu, Xu, Schultz, Peter G.

“…Osteoarthritis (OA) is a degenerative joint disease that involves the destruction of articular cartilage and eventually leads to disability. Molecules that…”
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Reshaping Antibody Diversity by Wang, Feng, Ekiert, Damian C., Ahmad, Insha, Yu, Wenli, Zhang, Yong, Bazirgan, Omar, Torkamani, Ali, Raudsepp, Terje, Mwangi, Waithaka, Criscitiello, Michael F., Wilson, Ian A., Schultz, Peter G., Smider, Vaughn V.

“…Some species mount a robust antibody response despite having limited genome-encoded combinatorial diversity potential. Cows are unusual in having exceptionally…”
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A Strategy for Creating Organisms Dependent on Noncanonical Amino Acids by Xuan, Weimin, Schultz, Peter G.

“…The use of noncanonical amino acids (ncAAs) to control the viability of an organism provides a strategy for the development of conditional “kill switches” for…”
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A regenerative approach to the treatment of multiple sclerosis by Deshmukh, Vishal A., Tardif, Virginie, Lyssiotis, Costas A., Green, Chelsea C., Kerman, Bilal, Kim, Hyung Joon, Padmanabhan, Krishnan, Swoboda, Jonathan G., Ahmad, Insha, Kondo, Toru, Gage, Fred H., Theofilopoulos, Argyrios N., Lawson, Brian R., Schultz, Peter G., Lairson, Luke L.

“…Progressive phases of multiple sclerosis are associated with inhibited differentiation of the progenitor cell population that generates the mature…”
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Genomically Recoded Organisms Expand Biological Functions by Lajoie, Marc J., Rovner, Alexis J., Goodman, Daniel B., Aerni, Hans-Rudolf, Haimovich, Adrian D., Kuznetsov, Gleb, Mercer, Jaron A., Wang, Harris H., Carr, Peter A., Mosberg, Joshua A., Rohland, Nadin, Schultz, Peter G., Jacobson, Joseph M., Rinehart, Jesse, Church, George M., Isaacs, Farren J.

“…We describe the construction and characterization of a genomically recoded organism (GRO). We replaced all known UAG stop codons in Escherichia coli MG1655…”
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Expanding the Genetic Code by Wang, Lei, Schultz, Peter G.

“…Although chemists can synthesize virtually any small organic molecule, our ability to rationally manipulate the structures of proteins is quite limited,…”
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Evolution of multiple, mutually orthogonal prolyl-tRNA synthetase/tRNA pairs for unnatural amino acid mutagenesis in Escherichia coli by Chatterjee, Abhishek, Xiao, Han, Schultz, Peter G

“…The site-specific incorporation of unnatural amino acids (UAAs) into proteins in living cells relies on an engineered tRNA/aminoacyl-tRNA synthetase…”
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The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis by Janes, Jeff, Young, Megan E., Chen, Emily, Rogers, Nicole H., Burgstaller-Muehlbacher, Sebastian, Hughes, Laura D., Love, Melissa S., Hull, Mitchell V., Kuhen, Kelli L., Woods, Ashley K., Joseph, Sean B., Petrassi, H. Michael, McNamara, Case W., Tremblay, Matthew S., Su, Andrew I., Schultz, Peter G., Chatterjee, Arnab K.

“…The chemical diversity and known safety profiles of drugs previously tested in humans make them a valuable set of compounds to explore potential therapeutic…”
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Functional Replacement of Histidine in Proteins To Generate Noncanonical Amino Acid Dependent Organisms by Gan, Fei, Liu, Renhe, Wang, Feng, Schultz, Peter G

“…Simple strategies to produce organisms whose growth is strictly dependent on the presence of a noncanonical amino acid are useful for the generation of live…”
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Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells by Boitano, Anthony E, Wang, Jian, Romeo, Russell, Bouchez, Laure C, Parker, Albert E, Sutton, Sue E, Walker, John R, Flaveny, Colin A, Perdew, Gary H, Denison, Michael S, Schultz, Peter G, Cooke, Michael P

“…Although practiced clinically for more than 40 years, the use of hematopoietic stem cell (HSC) transplants remains limited by the ability to expand these cells…”
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Versatile strategy for controlling the specificity and activity of engineered T cells by Ma, Jennifer S. Y., Kim, Ji Young, Kazane, Stephanie A., Choi, Sei-hyun, Yun, Hwa Young, Kim, Min Soo, Rodgers, David T., Pugh, Holly M., Singer, Oded, Sun, Sophie B., Fonslow, Bryan R., Kochenderfer, James N., Wright, Timothy M., Schultz, Peter G., Young, Travis S., Kim, Chan Hyuk, Cao, Yu

“…The adoptive transfer of autologous T cells engineered to express a chimeric antigen receptor (CAR) has emerged as a promising cancer therapy. Despite…”
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