Search Results - "Schultz, P. G"

Strategy for Probing the Function of Noncoding RNAs Finds a Repressor of NFAT by Willingham, A. T, Orth, A. P, Batalov, S, Peters, E. C, Wen, B. G, Aza-Blanc, P, Hogenesch, J. B, Schultz, P. G

“…Noncoding RNA molecules (ncRNAs) have been implicated in numerous biological processes including transcriptional regulation and the modulation of protein…”
Get full text

CXCR4 activation maintains a stem cell population in tamoxifen-resistant breast cancer cells through AhR signalling by Dubrovska, A, Hartung, A, Bouchez, L C, Walker, J R, Reddy, V A, Cho, C Y, Schultz, P G

“…Background: Tamoxifen is commonly used for breast cancer therapy. However, tamoxifen resistance is an important clinical problem. Continuous treatment with…”
Get full text

Expanding the Genetic Code of Escherichia coli by Wang, Lei, Brock, Ansgar, Herberich, Brad, Schultz, Peter G.

“…A unique transfer RNA (tRNA)/aminoacyl-tRNA synthetase pair has been generated that expands the number of genetically encoded amino acids in Escherichia coli…”
Get full text

Structure of a Copper-Mediated Base Pair in DNA by Atwell, Shane, Meggers, Eric, Spraggon, Glen, Schultz, Peter G

“…Stable and selective DNA base pairing by metal coordination was recently demonstrated with nucleotides containing complementary pyridine-2,6-dicarboxylate…”
Get full text

A Novel Copper-Mediated DNA Base Pair by Meggers, Eric, Holland, Patrick L, Tolman, William B, Romesberg, Floyd E, Schultz, Peter G

“…DNA encodes information in the sequence of the four deoxynucleotides dA, dT, dG, and dC. The key element for information storage and retrieval in this…”
Get full text

Organization of 'nanocrystal molecules' using DNA by Alivisatos, A. Paul, Johnsson, Kai P, Peng, Xiaogang, Wilson, Troy E, Loweth, Colin J, Bruchez, Marcel P, Schultz, Peter G

“…Patterning matter on the nanometre scale is an important objective of current materials chemistry and physics. It is driven by both the need to further…”
Get full text

An approach to rapid protein crystallization using nanodroplets by Santarsiero, B. D., Yegian, D. T., Lee, C. C., Spraggon, G., Gu, J., Scheibe, D., Uber, D. C., Cornell, E. W., Nordmeyer, R. A., Kolbe, W. F., Jin, J., Jones, A. L., Jaklevic, J. M., Schultz, P. G., Stevens, R. C.

“…An approach that enables up to a two order of magnitude reduction in the amount of protein required and a tenfold reduction in the amount of time required for…”
Get full text

From Molecular Diversity to Catalysis: Lessons from the Immune System by Schultz, Peter G., Lerner, Richard A.

“…By combining the enormous molecular diversity of the immune system with basic mechanistic principles of chemistry, one can produce catalytic antibodies that…”
Get full text

Structural Insights into the Evolution of an Antibody Combining Site by Wedemayer, Gary J., Patten, Phillip A., Wang, Leo H., Schultz, Peter G., Stevens, Raymond C.

“…The crystal structures of a germline antibody Fab fragment and its complex with hapten have been solved at 2.1 Å resolution. These structures are compared with…”
Get full text

A Combinatorial Approach to Materials Discovery by X.-D. Xiang, Sun, Xiaodong, Briceño, Gabriel, Lou, Yulin, Wang, Kai-An, Chang, Hauyee, Wallace-Freedman, William G., Chen, Sung-Wei, Schultz, Peter G.

“…A method that combines thin film deposition and physical masking techniques has been used for the parallel synthesis of spatially addressable libraries of…”
Get full text

Site-Specific Incorporation of Biophysical Probes into Proteins by CORNISH, V. W, BENSON, D. R, ALTENBACH, C. A, HIDEG, K, HUBBELL, W. L, SCHULTZ, P. G

“…Biophysical probes which can detect structural changes in proteins and the interaction of proteins with other macromolecules are important tools in studying…”
Get full text

Myoseverin, a microtubule-binding molecule with novel cellular effects by Schultz, Peter G, Rosania, Gustavo R, Chang, Young-Tae, Perez, Omar, Sutherlin, Daniel, Dong, Helin, Lockhart, David J

“…A new microtubule-binding molecule, myoseverin, was identified from a library of 2,6,9-trisubstituted purines in a morphological differentiation screen…”
Get full text

Efforts toward Expansion of the Genetic Alphabet:  Replication of DNA with Three Base Pairs by Tae, Eunju Lee, Wu, Yiqin, Xia, Gang, Schultz, Peter G, Romesberg, Floyd E

Get full text

Monitoring the Conformational Fluctuations of DNA Hairpins Using Single-Pair Fluorescence Resonance Energy Transfer by Grunwell, Jocelyn R, Glass, Jennifer L, Lacoste, Thilo D, Deniz, Ashok A, Chemla, Daniel S, Schultz, Peter G

“…We present single-pair fluorescence resonance energy transfer (spFRET) observations of individual opening and closing events of surface-immobilized DNA…”
Get full text

Designing Small-Molecule Switches for Protein-Protein Interactions by Guo, Zhihong, Zhou, Demin, Schultz, Peter G.

“…Mutations introduced into human growth hormone (hGH) (Thr175→ Gly-hGH) and the extracellular domain of the hGH receptor (Trp104→ Gly-hGHbp) created a cavity at…”
Get full text

Peptide Ligands for a Sugar-Binding Protein Isolated from a Random Peptide Library by Oldenburg, Kevin R., Loganathan, Duraikkannu, Goldstein, Irwin J., Shultz, Peter G., Gallop, Mark A.

“…Peptide ligands for the carbohydrate-binding protein concanavalin A (Con A) have been identified by screening a large, diverse peptide library expressed on the…”
Get full text

Nicotinic Receptor Binding Site Probed with Unnatural Amino Acid Incorporation in Intact Cells by Nowak, Mark W., Kearney, Patrick C., Sampson, Jeffrey R., Saks, Margaret E., Labarca, Cesar G., Silverman, Scott K., Zhong, Wenge, Thorson, Jon, Abelson, John N., Davidson, Norman, Schultz, Peter G., Dougherty, Dennis A., Lester, Henry A.

“…The nonsense codon suppression method for unnatural amino acid incorporation has been applied to intact cells and combined with electrophysiological analysis…”
Get full text

Immunological Origins of Binding and Catalysis in a Diels-Alderase Antibody by Romesberg, Floyd E., Spiller, Ben, Schultz, Peter G., Stevens, Raymond C.

“…The three-dimensional structure of an antibody (39-A11) that catalyzes a Diels-Alder reaction has been determined. The structure suggests that the antibody…”
Get full text

Design of Allele-Specific Protein Methyltransferase Inhibitors by Lin, Qing, Jiang, Fanyi, Schultz, Peter G, Gray, Nathanael S

“…Protein arginine methyltransferases, which catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to arginine side chains in target proteins,…”
Get full text

Scanning tip microwave near-field microscope by Wei, T., Xiang, X.-D., Wallace-Freedman, W. G., Schultz, P. G.

“…A near-field microscope which operates in the rf/microwave frequency range is described. In this microscope, a scanning tunneling microscope (STM)-like tip…”
Get full text