Search Results - "Schultz, J."

Development of a CRISPR/Cas9 system for high efficiency multiplexed gene deletion in Rhodosporidium toruloides by Schultz, J. Carl, Cao, Mingfeng, Zhao, Huimin

“…The oleaginous yeast Rhodosporidium toruloides is considered a promising candidate for production of chemicals and biofuels thanks to its ability to grow on…”
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Lung Microbiota Predict Clinical Outcomes in Critically Ill Patients by Dickson, Robert P, Schultz, Marcus J, van der Poll, Tom, Schouten, Laura R, Falkowski, Nicole R, Luth, Jenna E, Sjoding, Michael W, Brown, Christopher A, Chanderraj, Rishi, Huffnagle, Gary B, Bos, Lieuwe D J

“…Recent studies have revealed that, in critically ill patients, lung microbiota are altered and correlate with alveolar inflammation. The clinical significance…”
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Dual Insect specific virus infection limits Arbovirus replication in Aedes mosquito cells by Schultz, Michaela J., Frydman, Horacio M., Connor, John H.

“…Aedes mosquitoes are vectors for many pathogenic viruses. Cell culture systems facilitate the investigation of virus growth in the mosquito vector. We found…”
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Regulation of the metastatic cell phenotype by sialylated glycans by Schultz, Matthew J., Swindall, Amanda F., Bellis, Susan L.

“…Tumor cells exhibit striking changes in cell surface glycosylation as a consequence of dysregulated glycosyltransferases and glycosidases. In particular, an…”
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Arabinogalactan-Proteins: Key Regulators at the Cell Surface? by Ellis, Miriam, Egelund, Jack, Schultz, Carolyn J, Bacic, Antony

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Recent advances in domesticating non‐model microorganisms by Fatma, Zia, Schultz, J. Carl, Zhao, Huimin

“…Non‐model microorganisms have been increasingly explored as microbial cell factories for production of chemicals, fuels, and materials owing to their unique…”
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The Floating Signifier of ‘Safety’: Correctional Officer Perspectives on COVID-19 Restrictions, Legitimacy and Prison Order by Schultz, William J, Ricciardelli, Rosemary

“…Abstract The COVID-19 pandemic continues to affect prisons internationally. Existing research focuses on infection data, meaning we do not fully understand how…”
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The leaky gut and the gut microbiome in sepsis - targets in research and treatment by Chancharoenthana, Wiwat, Kamolratanakul, Supitcha, Schultz, Marcus J, Leelahavanichkul, Asada

“…Both a leaky gut (a barrier defect of the intestinal surface) and gut dysbiosis (a change in the intestinal microbial population) are intrinsic to sepsis…”
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Total Biosynthesis for Milligram-Scale Production of Etoposide Intermediates in a Plant Chassis by Schultz, Bailey J, Kim, Seung Yeon, Lau, Warren, Sattely, Elizabeth S

“…Etoposide is a plant-derived drug used clinically to treat several forms of cancer. Recent shortages of etoposide demonstrate the need for a more dependable…”
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Continuous glucose monitoring in the ICU: clinical considerations and consensus by Krinsley, James S, Chase, J Geoffrey, Gunst, Jan, Martensson, Johan, Schultz, Marcus J, Taccone, Fabio S, Wernerman, Jan, Bohe, Julien, De Block, Christophe, Desaive, Thomas, Kalfon, Pierre, Preiser, Jean-Charles

“…Glucose management in intensive care unit (ICU) patients has been a matter of debate for almost two decades. Compared to intermittent monitoring systems,…”
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Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method by Nasa, Prashant, Azoulay, Elie, Khanna, Ashish K, Jain, Ravi, Gupta, Sachin, Javeri, Yash, Juneja, Deven, Rangappa, Pradeep, Sundararajan, Krishnaswamy, Alhazzani, Waleed, Antonelli, Massimo, Arabi, Yaseen M, Bakker, Jan, Brochard, Laurent J, Deane, Adam M, Du, Bin, Einav, Sharon, Esteban, Andrés, Gajic, Ognjen, Galvagno, Jr, Samuel M, Guérin, Claude, Jaber, Samir, Khilnani, Gopi C, Koh, Younsuck, Lascarrou, Jean-Baptiste, Machado, Flavia R, Malbrain, Manu L N G, Mancebo, Jordi, McCurdy, Michael T, McGrath, Brendan A, Mehta, Sangeeta, Mekontso-Dessap, Armand, Mer, Mervyn, Nurok, Michael, Park, Pauline K, Pelosi, Paolo, Peter, John V, Phua, Jason, Pilcher, David V, Piquilloud, Lise, Schellongowski, Peter, Schultz, Marcus J, Shankar-Hari, Manu, Singh, Suveer, Sorbello, Massimiliano, Tiruvoipati, Ravindranath, Udy, Andrew A, Welte, Tobias, Myatra, Sheila N

“…Coronavirus disease 2019 (COVID-19) pandemic has caused unprecedented pressure on healthcare system globally. Lack of high-quality evidence on the respiratory…”
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Commonly Used Screening Instruments to Identify Frailty Among Community-Dwelling Older People in a General Practice (Primary Care) Setting: A Study of Diagnostic Test Accuracy by Ambagtsheer, Rachel C, Visvanathan, Renuka, Dent, Elsa, Yu, Solomon, Schultz, Timothy J, Beilby, Justin

“…Abstract Background Rapid frailty screening remains problematic in primary care. The diagnostic test accuracy (DTA) of several screening instruments has not…”
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Lipid imaging within the normal rat kidney using silver nanoparticles by matrix-assisted laser desorption/ionization mass spectrometry by Muller, Ludovic, Kailas, Ajay, Jackson, Shelley N, Roux, Aurelie, Barbacci, Damon C, Schultz, J Albert, Balaban, Carey D, Woods, Amina S

“…The well-characterized cellular and structural components of the kidney show distinct regional compositions and distribution of lipids. In order to more fully…”
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Incidence, Risk Factors, and Attributable Mortality of Secondary Infections in the Intensive Care Unit After Admission for Sepsis by van Vught, Lonneke A, Klein Klouwenberg, Peter M. C, Spitoni, Cristian, Scicluna, Brendon P, Wiewel, Maryse A, Horn, Janneke, Schultz, Marcus J, Nürnberg, Peter, Bonten, Marc J. M, Cremer, Olaf L, van der Poll, Tom

“…IMPORTANCE: Sepsis is considered to induce immune suppression, leading to increased susceptibility to secondary infections with associated late mortality…”
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Protective Mechanical Ventilation during General Anesthesia for Open Abdominal Surgery Improves Postoperative Pulmonary Function by Severgnini, Paolo, Selmo, Gabriele, Lanza, Christian, Chiesa, Alessandro, Frigerio, Alice, Bacuzzi, Alessandro, Dionigi, Gianlorenzo, Novario, Raffaele, Gregoretti, Cesare, de Abreu, Marcelo Gama, Schultz, Marcus J, Jaber, Samir, Futier, Emmanuel, Chiaranda, Maurizio, Pelosi, Paolo

“…BACKGROUND:The impact of intraoperative ventilation on postoperative pulmonary complications is not defined. The authors aimed at determining the effectiveness…”
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Dose-Dense Temozolomide for Newly Diagnosed Glioblastoma: A Randomized Phase III Clinical Trial by GILBERT, Mark R, MEIHUA WANG, MAHAJAN, Anita, SCHULTZ, Christopher J, ERRIDGE, Sara, BAUMERT, Brigitta, HOPKINS, Kristen I, TZUK-SHINA, Tzahala, BROWN, Paul D, CHAKRAVARTI, Arnab, CURRAN, Walter J, MEHTA, Minesh P, ALDAPE, Kenneth D, STUPP, Roger, HEGI, Monika E, JAECKLE, Kurt A, ARMSTRONG, Terri S, WEFEL, Jeffrey S, MINHEE WON, BLUMENTHAL, Deborah T

“…Radiotherapy with concomitant and adjuvant temozolomide is the standard of care for newly diagnosed glioblastoma (GBM). O(6)-methylguanine-DNA…”
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Volatile metabolites of pathogens: a systematic review by Bos, Lieuwe D J, Sterk, Peter J, Schultz, Marcus J

“…Ideally, invading bacteria are detected as early as possible in critically ill patients: the strain of morbific pathogens is identified rapidly, and…”
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Long-term Follow-up of the RTOG 9501/Intergroup Phase III Trial: Postoperative Concurrent Radiation Therapy and Chemotherapy in High-Risk Squamous Cell Carcinoma of the Head and Neck by Cooper, Jay S., MD, Zhang, Qiang, PhD, Pajak, Thomas F., PhD, Forastiere, Arlene A., MD, Jacobs, John, MD, Saxman, Scott B., MD, Kish, Julie A., MD, Kim, Harold E., MD, Cmelak, Anthony J., MD, Rotman, Marvin, MD, Lustig, Robert, MD, Ensley, John F., MD, Thorstad, Wade, MD, Schultz, Christopher J., MD, Yom, Sue S., MD, Ang, K. Kian, MD, PhD

“…Purpose Previous analysis of this Intergroup trial demonstrated that with a median follow-up among surviving patients of 45.9 months, the concurrent…”
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Effect of Intraoperative High Positive End-Expiratory Pressure (PEEP) With Recruitment Maneuvers vs Low PEEP on Postoperative Pulmonary Complications in Obese Patients: A Randomized Clinical Trial by Bluth, Thomas, Serpa Neto, Ary, Schultz, Marcus J, Pelosi, Paolo, Gama de Abreu, Marcelo

“…IMPORTANCE: An intraoperative higher level of positive end-expiratory positive pressure (PEEP) with alveolar recruitment maneuvers improves respiratory…”
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Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis by Cheng, Shih-Chin, Scicluna, Brendon P, Arts, Rob J W, Gresnigt, Mark S, Lachmandas, Ekta, Giamarellos-Bourboulis, Evangelos J, Kox, Matthijs, Manjeri, Ganesh R, Wagenaars, Jori A L, Cremer, Olaf L, Leentjens, Jenneke, van der Meer, Anne J, van de Veerdonk, Frank L, Bonten, Marc J, Schultz, Marcus J, Willems, Peter H G M, Pickkers, Peter, Joosten, Leo A B, van der Poll, Tom, Netea, Mihai G

“…Sepsis is poorly understood, largely untreatable and frequently fatal. Netea and colleagues assess both mouse sepsis and human sepsis to demonstrate that its…”
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