Search Results - "Schultz, Brian"

Biochemical characterization of tirabrutinib and other irreversible inhibitors of Bruton's tyrosine kinase reveals differences in on - and off - target inhibition by Liclican, Albert, Serafini, Loredana, Xing, Weimei, Czerwieniec, Gregg, Steiner, Bart, Wang, Ting, Brendza, Katherine M., Lutz, Justin D., Keegan, Kathleen S., Ray, Adrian S., Schultz, Brian E., Sakowicz, Roman, Feng, Joy Y.

“…Bruton's tyrosine kinase (BTK) is a key component of the B-cell receptor (BCR) pathway and a clinically validated target for small molecule inhibitors such as…”
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Hospital encounters for pediatric ingestions before and during the COVID-19 pandemic by Schultz, Brian R. E., Hoffmann, Jennifer A., Clancy, Cathleen, Ramgopal, Sriram

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The KN-93 Molecule Inhibits Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity by Binding to Ca2+/CaM by Wong, Melanie H., Samal, Alexandra B., Lee, Mike, Vlach, Jiri, Novikov, Nikolai, Niedziela-Majka, Anita, Feng, Joy Y., Koltun, Dmitry O., Brendza, Katherine M., Kwon, Hyock Joo, Schultz, Brian E., Sakowicz, Roman, Saad, Jamil S., Papalia, Giuseppe A.

“…Calcium/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine protein kinase that transmits calcium signals in various cellular…”
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Off-Target In Vitro Profiling Demonstrates that Remdesivir Is a Highly Selective Antiviral Agent by Xu, Yili, Barauskas, Ona, Kim, Cynthia, Babusis, Darius, Murakami, Eisuke, Kornyeyev, Dmytro, Lee, Gary, Stepan, George, Perron, Michel, Bannister, Roy, Schultz, Brian E, Sakowicz, Roman, Porter, Danielle, Cihlar, Tomas, Feng, Joy Y

“…Remdesivir (RDV, GS-5734), the first FDA-approved antiviral for the treatment of COVID-19, is a single diastereomer monophosphoramidate prodrug of an adenosine…”
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Recombinant Adeno-associated Virus Transduction and Integration by Schultz, Brian R, Chamberlain, Jeffrey S

“…Recombinant adeno-associated virus (rAAV) holds promise as a gene therapy vector for a multitude of genetic disorders such as hemophilia, cystic fibrosis, and…”
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ASK1 contributes to fibrosis and dysfunction in models of kidney disease by Liles, John T, Corkey, Britton K, Notte, Gregory T, Budas, Grant R, Lansdon, Eric B, Hinojosa-Kirschenbaum, Ford, Badal, Shawn S, Lee, Michael, Schultz, Brian E, Wise, Sarah, Pendem, Swetha, Graupe, Michael, Castonguay, Laurie, Koch, Keith A, Wong, Melanie H, Papalia, Giuseppe A, French, Dorothy M, Sullivan, Theodore, Huntzicker, Erik G, Ma, Frank Y, Nikolic-Paterson, David J, Altuhaifi, Tareq, Yang, Haichun, Fogo, Agnes B, Breckenridge, David G

“…Oxidative stress is an underlying component of acute and chronic kidney disease. Apoptosis signal-regulating kinase 1 (ASK1) is a widely expressed…”
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Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells by Li, Ruidong, Liclican, Albert, Xu, Yili, Pitts, Jared, Niu, Congrong, Zhang, Jingyu, Kim, Cynthia, Zhao, Xiaofeng, Soohoo, Daniel, Babusis, Darius, Yue, Qin, Ma, Bin, Murray, Bernard P, Subramanian, Raju, Xie, Xuping, Zou, Jing, Bilello, John P, Li, Li, Schultz, Brian E, Sakowicz, Roman, Smith, Bill J, Shi, Pei-Yong, Murakami, Eisuke, Feng, Joy Y

“…Remdesivir (RDV; GS-5734, Veklury), the first FDA-approved antiviral to treat COVID-19, is a single-diastereomer monophosphoramidate prodrug of an adenosine…”
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Interactions of Aqueous Ag+ with Fulvic Acids: Mechanisms of Silver Nanoparticle Formation and Investigation of Stability by Adegboyega, Nathaniel F, Sharma, Virender K, Siskova, Karolina, Zbořil, Radek, Sohn, Mary, Schultz, Brian J, Banerjee, Sarbajit

“…This study investigated the possible natural formation of silver nanoparticles (AgNPs) in Ag+–fulvic acid (FA) solutions under various environmentally relevant…”
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Arming Teachers: Who Will Bear the Burden? by Phadke, Meghan, Schultz, Brian D., Noltemeyer, Amity

“…As state legislatures increasingly turn their gaze to education and school policy, one intervention that is particularly concerning is the proposal to arm…”
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Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Polymerase activity and mechanisms of action of nucleotide analogs by Barauskas, Ona, Xing, Weimei, Aguayo, Esmeralda, Willkom, Madeleine, Sapre, Annapurna, Clarke, Michael, Birkus, Gabriel, Schultz, Brian E, Sakowicz, Roman, Kwon, HyockJoo, Feng, Joy Y

“…Influenza polymerase is a heterotrimer protein with both endonuclease and RNA-dependent RNA polymerase (RdRp) activity. It plays a critical role in viral RNA…”
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Structural, Biochemical, and Biophysical Characterization of Idelalisib Binding to Phosphoinositide 3-Kinase δ by Somoza, John R., Koditek, David, Villaseñor, Armando G., Novikov, Nikolai, Wong, Melanie H., Liclican, Albert, Xing, Weimei, Lagpacan, Leanna, Wang, Ruth, Schultz, Brian E., Papalia, Giuseppe A., Samuel, Dharmaraj, Lad, Latesh, McGrath, Mary E.

“…Idelalisib (also known as GS-1101, CAL-101, IC489666, and Zydelig) is a PI3Kδ inhibitor that has recently been approved for the treatment of several…”
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Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi by Taylor, James G., Zipfel, Sheila, Ramey, Kyla, Vivian, Randy, Schrier, Adam, Karki, Kapil K., Katana, Ashley, Kato, Darryl, Kobayashi, Tetsuya, Martinez, Ruben, Sangi, Michael, Siegel, Dustin, Tran, Chinh V., Yang, Zheng-Yu, Zablocki, Jeff, Yang, Cheng Y., Wang, Yujin, Wang, Kelly, Chan, Katie, Barauskas, Ona, Cheng, Guofeng, Jin, Debi, Schultz, Brian E., Appleby, Todd, Villaseñor, Armando G., Link, John O.

“…[Display omitted] Treatment of hepatitis C virus (HCV) infection has been historically challenging due the high viral genetic complexity wherein there are…”
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Effective Decontamination and Remediation After Elemental Mercury Exposure: A Case Report in the United States by Johnson-Arbor, Kelly, Schultz, Brian

“…Elemental mercury exposure can result in significant toxicity. Source decontamination and remediation are often required after larger elemental mercury…”
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Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus by Feng, Joy Y, Xu, Yili, Barauskas, Ona, Perry, Jason K, Ahmadyar, Shekeba, Stepan, George, Yu, Helen, Babusis, Darius, Park, Yeojin, McCutcheon, Krista, Perron, Michel, Schultz, Brian E, Sakowicz, Roman, Ray, Adrian S

“…Toxicity has emerged during the clinical development of many but not all nucleotide inhibitors (NI) of hepatitis C virus (HCV). To better understand the…”
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Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9 by Appleby, Todd C., Greenstein, Andrew E., Hung, Magdeleine, Liclican, Albert, Velasquez, Maile, Villaseñor, Armando G., Wang, Ruth, Wong, Melanie H., Liu, Xiaohong, Papalia, Giuseppe A., Schultz, Brian E., Sakowicz, Roman, Smith, Victoria, Kwon, Hyock Joo

“…Matrix metalloproteinase 9 (MMP9) is a member of a large family of proteases that are secreted as inactive zymogens. It is a key regulator of the extracellular…”
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Effect of pre-intercalation on Li-ion diffusion mapped by topochemical single-crystal transformation and operando investigation by Luo, Yuting, Handy, Joseph V., Das, Tisita, Ponis, John D., Albers, Ryan, Chiang, Yu-Hsiang, Pharr, Matt, Schultz, Brian J., Gobbato, Leonardo, Brown, Dean C., Chakraborty, Sudip, Banerjee, Sarbajit

“…Limitations in electrochemical performance as well as supply chain challenges have rendered positive electrode materials a critical bottleneck for Li-ion…”
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Discovery of Selective Irreversible Inhibitors for Bruton's Tyrosine Kinase by Pan, Zhengying, Scheerens, Heleen, Li, Shyr-Jiann, Schultz, Brian E., Sprengeler, Paul A., Burrill, L. Chuck, Mendonca, Rohan V., Sweeney, Michael D., Scott, Keana C. K., Grothaus, Paul G., Jeffery, Douglas A., Spoerke, Jill M., Honigberg, Lee A., Young, Peter R., Dalrymple, Stacie A., Palmer, James T.

“…A series of highly selective irreversible inhibitors for Bruton's tyrosine kinase (Btk) was developed using a structural bioinformatics approach. Their…”
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Cation reordering instead of phase transitions: Origins and implications of contrasting lithiation mechanisms in 1D ζ- and 2D α-V2O5 by Luo, Yuting, Rezaei, Shahed, Santos, David A, Zhang, Yuwei, Handy, Joseph V, Carrillo, Luis, Schultz, Brian J, Gobbato, Leonardo, Pupucevski, Max, Wiaderek, Kamila, Charalambous, Harry, Yakovenko, Andrey, Pharr, Matt, Xu, Bai-Xiang, Banerjee, Sarbajit

“…Substantial improvements in cycle life, rate performance, accessible voltage, and reversible capacity are required to realize the promise of Li-ion batteries…”
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Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Endonuclease activity and evaluation of inhibitors by Xing, Weimei, Barauskas, Ona, Kirschberg, Thorsten, Niedziela-Majka, Anita, Clarke, Michael, Birkus, Gabriel, Weissburg, Perry, Liu, Xiaohong, Schultz, Brian E, Sakowicz, Roman, Kwon, HyockJoo, Feng, Joy Y

“…Influenza polymerase is a heterotrimer composed of polymerase acidic protein A (PA) and basic proteins 1 (PB1) and 2 (PB2). The endonuclease active site,…”
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Soft X‑ray Absorption Spectroscopy Studies of the Electronic Structure Recovery of Graphene Oxide upon Chemical Defunctionalization by Lee, Vincent, Dennis, Robert V, Schultz, Brian J, Jaye, Cherno, Fischer, Daniel A, Banerjee, Sarbajit

“…A comparative evaluation of the efficacy of different reducing agents in defunctionalizing graphene oxide is performed using near-edge X-ray absorption fine…”
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