Search Results - "Schultheis, Nicholas"

Regulation of autophagy, lipid metabolism, and neurodegenerative pathology by heparan sulfate proteoglycans by Schultheis, Nicholas, Becker, Robert, Berhanu, Gelila, Kapral, Alexander, Roseman, Matthew, Shah, Shalini, Connell, Alyssa, Selleck, Scott

“…Heparan sulfate modified proteins or proteoglycans (HSPGs) are an abundant class of cell surface and extracellular matrix molecules. They serve important…”
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Heparan Sulfate Structure Affects Autophagy, Lifespan, Responses to Oxidative Stress, and Cell Degeneration in Drosophila parkin Mutants by Reynolds-Peterson, Claire, Xu, Jie, Zhao, Na, Cruse, Casey, Yonel, Brandon, Trasorras, Claire, Toyoda, Hidenao, Kinoshita-Toyoda, Akiko, Dobson, Jennifer, Schultheis, Nicholas, Jiang, Mei, Selleck, Scott

“…Autophagy is a catabolic process that provides cells with energy and molecular building blocks during nutritional stress. Autophagy also removes misfolded…”
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Putting the brakes on autophagy: The role of heparan sulfate modified proteins in the balance of anabolic and catabolic pathways and intracellular quality control by Schultheis, Nicholas, Jiang, Mei, Selleck, Scott B.

“…•Heparan sulfate modified proteins inhibit basal autophagy levels in multiple cell types and species.•Global changes in heparan sulfate structure increase…”
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Impaired mitophagy in Sanfilippo a mice causes hypertriglyceridemia and brown adipose tissue activation by Tillo, Miguel, Lamanna, William C., Dwyer, Chrissa A., Sandoval, Daniel R., Pessentheiner, Ariane R., Al-Azzam, Norah, Sarrazin, Stéphane, Gonzales, Jon C., Kan, Shih-Hsin, Andreyev, Alexander Y., Schultheis, Nicholas, Thacker, Bryan E., Glass, Charles A., Dickson, Patricia I., Wang, Raymond Y., Selleck, Scott B., Esko, Jeffrey D., Gordts, Philip L.S.M.

“…Lysosomal storage diseases result in various developmental and physiological complications, including cachexia. To study the causes for the negative energy…”
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Altering heparan sulfate suppresses cell abnormalities and neuron loss in Drosophila presenilin model of Alzheimer Disease by Schultheis, Nicholas, Connell, Alyssa, Kapral, Alexander, Becker, Robert J., Mueller, Richard, Shah, Shalini, O'Donnell, Mackenzie, Roseman, Matthew, Swanson, Lindsey, DeGuara, Sophia, Wang, Weihua, Yin, Fei, Saini, Tripti, Weiss, Ryan J., Selleck, Scott B.

“…We examined the function of heparan-sulfate-modified proteoglycans (HSPGs) in pathways affecting Alzheimer disease (AD)-related cell pathology in human cell…”
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