Search Results - "Schultes, B"

Central nervous insulin resistance: a promising target in the treatment of metabolic and cognitive disorders by Hallschmid, M, Schultes, B

“…Research on functions and signalling pathways of insulin has traditionally focused on peripheral tissues such as muscle, fat and liver, while the brain was…”
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Intranasal administration of insulin to the brain impacts cognitive function and peripheral metabolism by Ott, V., Benedict, C., Schultes, B., Born, J., Hallschmid, M.

“…In recent years, the central nervous system (CNS) has emerged as a principle site of insulin action. This notion is supported by studies in animals relying on…”
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Efficacy and safety of oral semaglutide with flexible dose adjustment versus sitagliptin in type 2 diabetes (PIONEER 7): a multicentre, open-label, randomised, phase 3a trial by Pieber, Thomas R, Bode, Bruce, Mertens, Ann, Cho, Young Min, Christiansen, Erik, Hertz, Christin L, Wallenstein, Signe O R, Buse, John B, Akın, S, Aladağ, N, Arif, A A, Aronne, L J, Aronoff, S, Ataoglu, E, Baik, S H, Bays, H, Beckett, P L, Berker, D, Bilz, S, Bode, B, Braun, E W, Buse, J B, Canani, L H S, Cho, Y M, Chung, C H, Colin, I, Condit, J, Cooper, J, Delgado, B, Eagerton, D C, El Ebrashy, I N, El Hefnawy, M H M F, Eliaschewitz, F G, Finneran, M P, Fischli, S, Fließer-Görzer, E, Geohas, J, Godbole, N A, Golay, A, Gorban de Lapertosa, S, Gross, J L, Gulseth, H L, Helland, F, Høivik, H O, Issa, C, Kang, E S, Keller, C, Khalil, S H A, Kim, N H, Kim, I J, Klaff, L J, Laimer, M, LaRocque, J C, Lederman, S N, Lee, K-W, Litchfield, W R, Manning, M B, Mertens, A, Morawski, E J, Murray, A V, Nicol, P R, O'Connor, T M, Oğuz, A, Ong, S, Özdemir, A, Palace, E M, Palchick, B A, Pereles-Ortiz, J, Pieber, T, Prager, R, Preumont, V, Riffer, E, Rista, L, Rudofsky, G, Sarı, R, Scheen, A, Schultes, B, Seo, J A, Shelbaya, S A, Sivalingam, K, Sorli, C H, Stäuble, S, Streja, D A, T'Sjoen, G, Tetiker, T, Van Gaal, L, Vercammen, C, Warren, M L, Weinstein, D L, Weiss, D, White, A, Winnie, M, Wium, C, Yavuz, D

“…Oral semaglutide is the first oral formulation of a glucagon-like peptide-1 (GLP-1) receptor agonist developed for the treatment of type 2 diabetes. We aimed…”
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Altered brain activity in severely obese women may recover after Roux-en Y gastric bypass surgery by Frank, S, Wilms, B, Veit, R, Ernst, B, Thurnheer, M, Kullmann, S, Fritsche, A, Birbaumer, N, Preissl, H, Schultes, B

“…Objective: Neuroimaging studies have demonstrated alterations in brain activity in obese (OB) subjects that might be causally linked to their disorder. Roux-en…”
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Obese men respond to cognitive but not to catabolic brain insulin signaling by Hallschmid, M, Benedict, C, Schultes, B, Born, J, Kern, W

“…Context and objective: Insulin acts in the brain to reduce food intake and body weight and is considered a major adiposity signal in energy homeostasis. In…”
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Correction factors for the calculation of metabolic equivalents (MET) in overweight to extremely obese subjects by Wilms, B, Ernst, B, Thurnheer, M, Weisser, B, Schultes, B

“…Background/Objectives: The metabolic equivalent (MET) is a construct that is commonly used to quantify physical activity as well as exercise performance. ‘One…”
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Plasma omentin-1 levels are related to exercise performance in obese women and increase upon aerobic endurance training by Wilms, B, Ernst, B, Gerig, R, Schultes, B

“…Omentin-1 is an adipokine that is primarily released from visceral adipose tissue stromal cells. The effects of exercise on omentin-1 regulation are not clear…”
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The selfish brain: competition for energy resources by Peters, A., Schweiger, U., Pellerin, L., Hubold, C., Oltmanns, K.M., Conrad, M., Schultes, B., Born, J., Fehm, H.L.

“…The brain occupies a special hierarchical position in the organism. It is separated from the general circulation by the blood-brain barrier, has high energy…”
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Clinical benefits of switching to insulin degludec irrespective of previous basal insulin therapy in people with Type 1 or Type 2 diabetes: evidence from a European, multicentre, retrospective, non‐interventional study (EU‐TREAT) by Knudsen, S. T., Lapolla, A., Schultes, B., Tentolouris, N., Catarig, A.‐M., Wolden, M. L., Siegmund, T.

“…Aims To investigate whether the benefits of switching to insulin degludec observed in the European retrospective chart review study EU‐TREAT were dependent on…”
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Low cerebrospinal fluid insulin levels in obese humans by KERN, W, BENEDICT, C, SCHULTES, B, PLOHR, F, MOSER, A, BORN, J, FEHM, H. L, HALLSCHMID, M

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Comment on: Nathan DM, Buse JB, Davidson MB et al (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 49: 1711–1721 by Schultes, B.

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Whole body vibration added to endurance training in obese women - a pilot study by Wilms, B, Frick, J, Ernst, B, Mueller, R, Wirth, B, Schultes, B

“…Whole body vibration (WBV) training is an increasingly popular training method that is strongly promoted for weight loss, but scientific data on its…”
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The Hedonic Drive to Consume Palatable Foods Appears to be Lower in Gastric Band Carriers than in Severely Obese Patients Who Have Not Undergone a Bariatric Surgery by Ullrich, J., Ernst, B., Wilms, B., Thurnheer, M., Hallschmid, M., Schultes, B.

“…Background We have recently shown that severely obese patients display a markedly enhanced drive to consume palatable food, and that this hedonic hunger is…”
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Cardio-respiratory fitness is independently associated with cardio-metabolic risk markers in severely obese women by Waldburger, R, Wilms, B, Ernst, B, Thurnheer, M, Schultes, B

“…Many studies have shown an inverse relationship between cardio-respiratory fitness and cardio-metabolic risk markers in normal-weight to moderately obese…”
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Phase I trial of a murine antibody to MUC1 in patients with metastatic cancer: evidence for the activation of humoral and cellular antitumor immunity by de Bono, J. S., Rha, S. Y., Stephenson, J., Schultes, B. C., Monroe, P., Eckhardt, G. S., Hammond, L. A., Whiteside, T. L., Nicodemus, C. F., Cermak, J. M., Rowinsky, E. K., Tolcher, A. W.

“…Background: BrevaRex® mAb-AR20.5 is a murine anti-MUC1 monoclonal antibody generated to induce MUC1 antigen-specific immune responses through the formation of…”
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The effect of 6-weeks of aerobic exercise training on serum fetuin-A levels in non-diabetic obese women by Schultes, B, Frick, J, Ernst, B, Stefan, N, Fritsche, A

“…Emerging evidence suggests that fetuin-A, a liver-derived glycoprotein, represents an important factor in the pathophysiology of the metabolic syndrome, type 2…”
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Serum adiponectin concentrations during a 72-hour fast in over- and normal-weight humans by MERL, V, PETERS, A, OLTMANNS, K. M, KERN, W, BORN, J, FEHM, H. L, SCHULTES, B

“…Adiponectin is currently considered an important link between obesity and insulin resistance, since circulating levels of this insulin sensitizing hormone have…”
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A pilot phase 2 study of oregovomab murine monoclonal antibody to CA125 as an immunotherapeutic agent for recurrent ovarian cancer by Ehlen, T G, Hoskins, P J, Miller, D, Whiteside, T L, Nicodemus, C F, Schultes, B C, Swenerton, K D

“…This prospective, open-label, pilot phase 2 study examined the clinical and immunologic effects of oregovomab (OvaRex) in heavily pretreated patients with…”
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Blocking AMPA receptor signalling by caroverine infusion does not affect counter-regulation of hypoglycaemia in healthy men by Klement, J, Pais, I, Hallschmid, M, Hubold, C, Knispel, A, Oltmanns, K. M, Schultes, B, Born, J, Peters, A

“…Aims/hypothesis Glutamatergic pathways are assumed to play a critical role in the hormonal stress response to hypoglycaemia. In rats, glutamate signalling at…”
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Short-term nocturnal hypoglycaemia increases morning food intake in healthy humans by Schmid, S. M., Jauch-Chara, K., Hallschmid, M., Oltmanns, K. M., Born, J., Schultes, B.

“…Aims  Hypoglycaemia during wakefulness increases hunger and food intake. Patients with Type 1 diabetes mellitus are at high risk of recurrent hypoglycaemia and…”
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