Search Results - "Schullek, John R"

EMS Triage and Transport of Intoxicated Individuals to a Detoxification Facility Instead of an Emergency Department by Ross, David W., DO, Schullek, John R., PhD, NREMT-B, Homan, Mark B., MPA, NREMT-P

“…Study objective We evaluate the effectiveness and safety of emergency medical services (EMS) provider use of a checklist to triage alcohol-inebriated patients…”
Get full text

Combinatorial Organic Synthesis of Highly Functionalized Pyrrolidines: Identification of a Potent Angiotensin Converting Enzyme Inhibitor from a Mercaptoacyl Proline Library by Murphy, Martin M, Schullek, John R, Gordon, Eric M, Gallop, Mark A

Get full text

Encoded Combinatorial Chemistry: Synthesis and Screening of a Library of Highly Functionalized Pyrrolidines by Maclean, Derek, Schullek, John R., Murphy, Martin M., Ni, Zhi-Jie, Gordon, Eric M., Gallop, Mark A.

“…The application of a new encoding technology for drug discovery is described. A combinatorial library of mercaptoacyl pyrrolidines has been prepared on a…”
Get full text

The discovery of biaryl acids and amides exhibiting antibacterial activity against Gram-positive bacteria by Look, Gary C., Vacin, Charles, Dias, Tracy M., Ho, Sun, Tran, Thuy H., Lee, Laurance L., Wiesner, Cedric, Fang, Flora, Marra, Andrea, Westmacott, Don, Hromockyj, Alexander E., Murphy, Martin M., Schullek, John R.

“…Solid-phase synthetic methods for biaryl-based compounds were developed resulting in the construction of two 1000-member libraries. Numerous compounds were…”
Get full text

Factors Associated With the Interfacility Transfer of the Pediatric Trauma Patient: Implications for Prehospital Triage by Ross, David W, Rewers, Arleta, Homan, Mark B, Schullek, John R, Hawke, Jesse L, Hedegaard, Holly

“…OBJECTIVEThe goal of this study was to identify prehospital factors associated with increased likelihood of interfacility transfer of pediatric trauma…”
Get full text

The identification of cyclooxygenase-1 inhibitors from 4-thiazolidinone combinatorial libraries by Look, Gary C., Schullek, John R., Holmes, Christopher P., Chinn, Jason P., Gordon, Eric M., Gallop, Mark A.

“…Three 4-thiazolidinone libraries, each containing up to 540 compounds, were prepared and assayed for inhibition of the enzyme cyclooxygenase-1 (COX-1)…”
Get full text

A High-Density Screening Format for Encoded Combinatorial Libraries: Assay Miniaturization and Its Application to Enzymatic Reactions by Schullek, John R., Butler, John H., Ni, Zhi-Jie, Chen, Dawn, Yuan, Zhengyu

“…A novel, miniaturized high-throughput screening format is described for assay of combinatorial libraries generated on beads. This approach, which is ideally…”
Get full text

Mutational Mapping of Functional Residues in Tissue Factor: Identification of Factor VII Recognition Determinants in Both Structural Modules of the Predicted Cytokine Receptor Homology Domain by Ruf, Wolfram, Schullek, John R, Stone, Martin J, Edgington, Thomas S

“…Alanine scanning mutagenesis of tissue factor, the initiating receptor and cofactor molecule for the coagulation pathways, was used to define residue side…”
Get full text

Energetic Contributions and Topographical Organization of Ligand Binding Residues of Tissue Factor by Ruf, Wolfram, Kelly, Curtis R, Schullek, John R, Martin, David M. A, Polikarpov, Igor, Boys, C. William G, Tuddenham, Edward G. D, Edgington, Thomas S

“…Tissue factor is the cellular receptor and macromolecular enzymatic cofactor for the serine protease coagulation factor VIIa. The ligand binding extracellular…”
Get full text

Combinatorial Organic Synthesis of Highly Functionalized Pyrrolidines:  Identification of a Potent Angiotensin Converting Enzyme Inhibitor from a Mercaptoacyl Proline Library J. Am. Chem. Soc. 1995, 117, 7029−7030 by Murphy, Martin M, Schullek, John R, Gordon, Eric M, Gallop, Mark A

Get full text

Key ligand interface residues in tissue factor contribute independently to factor VIIa binding by SCHULLEK, J. R, RUF, W, EDGINGTON, T. S

“…Scanning alanine mutagenesis of the cell surface protease receptor tissue factor suggested importance of residues Lys20, Ile22, Asp58, Arg135, and Phe140 for…”
Get full text

Exploring structure-activity relationships around the phosphomannose isomerase inhibitor AF14049 via combinatorial synthesis by Bhandari, Ashok, Jones, David G., Schullek, John R., Kham Vo, Schunk, Caryn A., Tamanaha, Lisa L., Chen, Dawn, Yuan, Zhengyu, Needels, Michael C., Gallop, Mark A.

“…Phosphomannose Isomerase (PMI) has been shown by genetic methods to be an essential enzyme in fungal cell wall biosynthesis. The PMI inhibitor AF14049 was…”
Get full text

A Reconstituted Dilute Blood Clot Lysis Assay for the Medium Throughput Screening of Thrombolytic Compounds by Gadbut, Albert P., Schullek, John R., Hanel, Arthur M., MacAllan, David R.E.

“…Antithrombotic and clotting factors have long been targets for drug discovery, necessitating the development of blood assays to determine the efficacy of lead…”
Get full text

The alkylating properties of chlorambucil by Kundu, G C, Schullek, J R, Wilson, I B

“…Previous work has indicated an aziridinium ion mechanism in the hydrolysis of chlorambucil, and the present work on the alkylation of nucleophiles fully…”
Get more information

Tissue Factor residue Asp44 regulates catalytic function of the bound proteinase Factor VIIa by Kelly, C R, Schullek, J R, Ruf, W, Edgington, T S

“…The coagulation pathways are initiated by the cell-surface receptor Tissue Factor (TF), which binds the serine proteinase coagulation Factor VIIa (VIIa),…”
Get full text

Purification of bovine angiotensin converting enzyme by Schullek, J R, Wilson, I B

“…A change has been made in the commonly used lisinopril affinity gel procedure for purifying angiotensin converting enzyme. The new method greatly decreases the…”
Get more information

The binding of zinc to angiotensin-converting enzyme by Schullek, J R, Wilson, I B

“…The equilibrium constant for the dissociation of zinc ion from angiotensin-converting enzyme (ACE) was measured using zinc ion buffers of zinc chloride and…”
Get more information

Angiotensin converting enzyme: substrate inhibition by Schullek, J R, Wilson, I B

“…Phosphate, borate, and Tris inhibit angiotensin converting enzyme (ACE), but HEPES buffer is inert. Measurements of substrate inhibition were made in HEPES…”
Get more information

Hybridization and partial cDNA sequence analyses of bovine lung angiotensin I-converting enzyme by Deluca-Flaherty, C, Schullek, J R, Wilson, I B, Harris, R B

“…The mRNA encoding angiotensin I-converting enzyme, a zinc-metallo dipeptidyl carboxyhydrolase, has been identified in extracts prepared from bovine lung…”
Get more information