Search Results - "Schulga, A."

Real-time surface functionalization of a nanophotonic sensor for liquid biopsy by Kuzin, A., Chernyshev, V., Kovalyuk, V., An, P., Golikov, A., Svyatodukh, S., Perevoschikov, S., Florya, I., Schulga, A., Deyev, S., Goltsman, G., Gorin, D.

“…Today, the search for disease biomarkers and techniques for their detection is one of the most important focuses in modern healthcare. Extracellular vesicles…”
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HER2-Specific Targeted Toxin DARPin-LoPE: Immunogenicity and Antitumor Effect on Intraperitoneal Ovarian Cancer Xenograft Model by Sokolova, Evgeniya A, Shilova, Olga N, Kiseleva, Daria V, Schulga, Alexey A, Balalaeva, Irina V, Deyev, Sergey M

“…High immunogenicity and systemic toxicity are the main obstacles limiting the clinical use of the therapeutic agents based on exotoxin A. In this work, we…”
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UCNP-based Photoluminescent Nanomedicines for Targeted Imaging and Theranostics of Cancer by Guryev, Evgenii L, Smyshlyaeva, Anita S, Shilyagina, Natalia Y, Sokolova, Evgeniya A, Shanwar, Samah, Kostyuk, Alexey B, Lyubeshkin, Alexander V, Schulga, Alexey A, Konovalova, Elena V, Lin, Quan, Roy, Indrajit, Balalaeva, Irina V, Deyev, Sergey M, Zvyagin, Andrei V

“…Theranostic approach is currently among the fastest growing trends in cancer treatment. It implies the creation of multifunctional agents for simultaneous…”
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Polymer/magnetite carriers functionalized by HER2-DARPin: Avoiding lysosomes during internalization and controlled toxicity of doxorubicin by focused ultrasound induced release by Novoselova, M.V., Shramova, E.I., Sergeeva, O.V., Shcherbinina, E.Y., Perevoschikov, S.V., Melnikov, P., Griaznova, O.Yu, Sergeev, I.S., Konovalova, E.V., Schulga, A.A., Proshkina, G.M., Zatsepin, T.S., Deyev, S.M., Gorin, D.A.

“…Nanomedicine has revolutionized the available treatment options during the last decade, but poor selectivity of targeted drug delivery and release is still…”
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Spatial Structure and pH-dependent Conformational Diversity of Dimeric Transmembrane Domain of the Receptor Tyrosine Kinase EphA1 by Bocharov, Eduard V., Mayzel, Maxim L., Volynsky, Pavel E., Goncharuk, Marina V., Ermolyuk, Yaroslav S., Schulga, Alexey A., Artemenko, Elena O., Efremov, Roman G., Arseniev, Alexander S.

“…Eph receptors are found in a wide variety of cells in developing and mature tissues and represent the largest family of receptor tyrosine kinases, regulating…”
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Targeted Delivery of HSP70 to Tumor Cells via Supramolecular Complex Based on HER2-Specific DARPin9_29 and the Barnase:Barstar Pair by Alekseeva, Ludmila G, Ovsyanikova, Olga V, Schulga, Alexey A, Grechikhina, Maria V, Shustova, Olga A, Kovalenko, Elena I, Svirshchevskaya, Elena V, Deyev, Sergey M, Sapozhnikov, Alexander M

“…(1) Background: We have previously shown that the use of an artificial supramolecular two-component system based on chimeric recombinant proteins…”
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Immunoliposomes As a Promising Antiviral Agent against SARS-CoV-2 by Bobik, T. V., Simonova, M. A., Rushkevich, N. U., Kostin, N. N., Skryabin, G. A., Knorre, V. D., Schulga, A. A., Konovalova, E. V., Proshkina, G. M., Gabibov, A. G., Deev, S. M.

“…According to the World Health Organization, as of January 3, 2020 to September 13, 2023, there were approximately 23 million confirmed cases of COVID-19…”
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Unique Dimeric Structure of BNip3 Transmembrane Domain Suggests Membrane Permeabilization as a Cell Death Trigger by Bocharov, Eduard V., Pustovalova, Yulia E., Pavlov, Konstantin V., Volynsky, Pavel E., Goncharuk, Marina V., Ermolyuk, Yaroslav S., Karpunin, Dmitry V., Schulga, Alexey A., Kirpichnikov, Michail P., Efremov, Roman G., Maslennikov, Innokenty V., Arseniev, Alexander S.

“…BNip3 is a prominent representative of apoptotic Bcl-2 proteins with rather unique properties initiating an atypical programmed cell death pathway resembling…”
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Construction of the plasmid-free strain for human growth hormone production by Schulga, A.A., Mechev, P.V., Kirpichnikov, M.P., Skryabin, K.G., Deyev, S.M.

“…The E. coli strain, overproducing human growth hormone (hGH) was made by integration of the hGH gene under the control of T7 promoter into the chromosomal LacZ…”
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Barnase-barstar Specific Interaction Regulates Car-T Cells Cytotoxic Activity toward Malignancy by Kalinin, R. S., Shipunova, V. O., Rubtsov, Y. P., Ukrainskay, V. M., Schulga, A., Konovalova, E. V., Volkov, D. V., Yaroshevich, I. A., Moysenovich, A. M., Belogurov, A. A., Telegin, G. B., Chernov, A. S., Maschan, M. A., Terekhov, S. S., Knorre, V. D., Khurs, E., Gnuchev, N. V., Gabibov, A. G., Deyev, S. M.

“…The development of CAR-T specific therapy made a revolution in modern oncology. Despite the pronounced therapeutic effects, this novel approach displayed…”
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Structure and functional studies of the ribonuclease binase Glu43Ala/Phe81Ala mutant by Mitkevich, V. A., Schulga, A. A., Trofimov, A. A., Dorovatovskii, P. V., Goncharuk, D. A., Tkach, E. N., Makarov, A. A., Polyakov, K. M.

“…Ribonuclease from Bacillus intermedius (binase) is a small basic protein with antitumour activity. The three‐dimensional structure of the binase mutant form…”
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Synthesis of Magnetic Nanoparticles Stabilized by Magnetite-Binding Protein for Targeted Delivery to Cancer Cells by Kotelnikova, P. A., Shipunova, V. O., Aghayeva, U. F., Stremovskiy, O. A., Nikitin, M. P., Novikov, I. A., Schulga, A. A., Deyev, S. M., Petrov, R. V.

“…A new method for obtaining biomodified magnetite nanoparticles for targeted delivery to cells was developed. The method is based on the use of the C-terminal…”
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Removal of the Translocation Domain and the Furin Cleavage Site Decreases the Relative Hepatotoxicity of the Targeted Antitumor Toxins by Khodarovich, Yu. M., Konovalova, E. V., Schulga, A. A., Deyev, S. M., Petrov, R. V.

“…Targeted toxins are promising anticancer agents that allow selectively destroying cancer cells due to the increased content of onco-specific markers on their…”
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Data on characterization of magnetic nanoparticles stabilized with fusion protein of Barstar and C-term part of Mms6 by Shipunova, Victoria O., Kotelnikova, Polina A., Aghayeva, Ulkar F., Stremovskiy, Oleg A., Schulga, Alexey A., Nikitin, Maxim P., Deyev, Sergey M.

“…Mms6 is a protein that plays crucial role in the biomineralization and formation of magnetosomes in magnetotactic bacteria Magnetospirillum magneticum (strain…”
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Loop 3 of Short Neurotoxin II is an Additional Interaction Site with Membrane-bound Nicotinic Acetylcholine Receptor as Detected by Solid-state NMR Spectroscopy by Krabben, Ludwig, van Rossum, Barth-Jan, Jehle, Stefan, Bocharov, Eduard, Lyukmanova, Ekaterina N., Schulga, Alexey A., Arseniev, Alexander, Hucho, Ferdinand, Oschkinat, Hartmut

“…The contact area of neurotoxin II from Naja naja oxiana when interacting with the membrane-bound nicotinic acetylcholine receptor from Torpedo californica was…”
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Dimeric structure of the transmembrane domain of glycophorin a in lipidic and detergent environments by Mineev, K S, Bocharov, E V, Volynsky, P E, Goncharuk, M V, Tkach, E N, Ermolyuk, Ya S, Schulga, A A, Chupin, V V, Maslennikov, I V, Efremov, R G, Arseniev, A S

“…Specific interactions between transmembrane α-helices, to a large extent, determine the biological function of integral membrane proteins upon normal…”
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Dual Regioselective Targeting the Same Receptor in Nanoparticle-Mediated Combination Immuno/Chemotherapy for Enhanced Image-Guided Cancer Treatment by Shipunova, Victoria O, Komedchikova, Elena N, Kotelnikova, Polina A, Zelepukin, Ivan V, Schulga, Alexey A, Proshkina, Galina M, Shramova, Elena I, Kutscher, Hilliard L, Telegin, Georgij B, Kabashin, Andrei V, Prasad, Paras N, Deyev, Sergey M

“…When combined with immunotherapy, image-guided targeted delivery of chemotherapeutic agents is a promising direction for combination cancer theranostics, but…”
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Structural Basis of Activity of HER2-Targeting Construct Composed of DARPin G3 and Albumin-Binding Domains by Konshina, Anastasia G, Bocharov, Eduard V, Konovalova, Elena V, Schulga, Alexey A, Tolmachev, Vladimir, Deyev, Sergey M, Efremov, Roman G

“…Non-immunoglobulin-based scaffold proteins (SPs) represent one of the key therapeutic target-specific and high-affinity binders in modern medicine. Among their…”
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Data of self-made Taq DNA polymerase prepared for screening purposes by Konovalova, E.V., Schulga, A.A., Lukyanova, T.I., Woo, E.J., Deyev, S.M.

“…DNA analysis is a key procedure in genetic engineering. Nowadays the analysis is often done by PCR with Taq DNA polymerase. Although the last enzyme price is…”
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Expression, purification, and characterization of human enteropeptidase catalytic subunit in Escherichia coli by Gasparian, Marine E., Ostapchenko, Valeriy G., Schulga, Alexey A., Dolgikh, Dmitry A., Kirpichnikov, Mikhail P.

“…Enteropeptidase (synonym: enterokinase, EC 3.4.21.9) is a heterodimeric serine protease of the intestinal brush border that activates trypsinogen by highly…”
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