Search Results - "Schuldiner, Oren"

Mechanisms of developmental neurite pruning by Schuldiner, Oren, Yaron, Avraham

“…The precise wiring of the nervous system is a combined outcome of progressive and regressive events during development. Axon guidance and synapse formation…”
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Common and Divergent Mechanisms in Developmental Neuronal Remodeling and Dying Back Neurodegeneration by Yaron, Avraham, Schuldiner, Oren

“…Cell death is an inherent process that is required for the proper wiring of the nervous system. Studies over the last four decades have shown that, in a…”
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Tissue-specific (ts)CRISPR as an efficient strategy for in vivo screening in Drosophila by Meltzer, Hagar, Marom, Efrat, Alyagor, Idan, Mayseless, Oded, Berkun, Victoria, Segal-Gilboa, Netta, Unger, Tamar, Luginbuhl, David, Schuldiner, Oren

“…Gene editing by CRISPR/Cas9 is commonly used to generate germline mutations or perform in vitro screens, but applicability for in vivo screening has so far…”
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Spatiotemporal Control of Neuronal Remodeling by Cell Adhesion Molecules: Insights From Drosophila by Meltzer, Hagar, Schuldiner, Oren

“…Developmental neuronal remodeling is required for shaping the precise connectivity of the mature nervous system. Remodeling involves pruning of exuberant…”
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Nitric Oxide as a Switching Mechanism between Axon Degeneration and Regrowth during Developmental Remodeling by Rabinovich, Dana, Yaniv, Shiri P., Alyagor, Idan, Schuldiner, Oren

“…During development, neurons switch among growth states, such as initial axon outgrowth, axon pruning, and regrowth. By studying the stereotypic remodeling of…”
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Astrocytes play a key role in Drosophila mushroom body axon pruning by Hakim, Yaniv, Yaniv, Shiri P, Schuldiner, Oren

“…Axon pruning is an evolutionarily conserved strategy used to remodel neuronal connections during development. The Drosophila mushroom body (MB) undergoes…”
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Combining Developmental and Perturbation-Seq Uncovers Transcriptional Modules Orchestrating Neuronal Remodeling by Alyagor, Idan, Berkun, Victoria, Keren-Shaul, Hadas, Marmor-Kollet, Neta, David, Eyal, Mayseless, Oded, Issman-Zecharya, Noa, Amit, Ido, Schuldiner, Oren

“…Developmental neuronal remodeling is an evolutionarily conserved mechanism required for precise wiring of nervous systems. Despite its fundamental role in…”
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Role and Regulation of Starvation-Induced Autophagy in the Drosophila Fat Body by Scott, Ryan C., Schuldiner, Oren, Neufeld, Thomas P.

“…In response to starvation, eukaryotic cells recover nutrients through autophagy, a lysosomal-mediated process of cytoplasmic degradation. Autophagy is known to…”
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A fly's view of neuronal remodeling by Yaniv, Shiri P, Schuldiner, Oren

“…Developmental neuronal remodeling is a crucial step in sculpting the final and mature brain connectivity in both vertebrates and invertebrates. Remodeling…”
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Actin-dependent astrocytic infiltration is a key step for axon defasciculation during remodeling by Marmor-Kollet, Neta, Berkun, Victoria, Cummings, Gideon, Keren-Shaul, Hadas, David, Eyal, Addadi, Yoseph, Schuldiner, Oren

“…Astrocytes are essential for synapse formation, maturation, and plasticity; however, their function during developmental neuronal remodeling is largely…”
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piggyBac-Based Mosaic Screen Identifies a Postmitotic Function for Cohesin in Regulating Developmental Axon Pruning by Schuldiner, Oren, Berdnik, Daniela, Levy, Jonathan Ma, Wu, Joy S., Luginbuhl, David, Gontang, Allison Camille, Luo, Liqun

“…Developmental axon pruning is widely used to refine neural circuits. We performed a mosaic screen to identify mutations affecting axon pruning of Drosophila…”
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Pruning deficits of the developing Drosophila mushroom body result in mild impairment in associative odour learning and cause hyperactivity by Poppinga, Haiko, Çoban, Büşra, Meltzer, Hagar, Mayseless, Oded, Widmann, Annekathrin, Schuldiner, Oren, Fiala, André

“…The principles of how brain circuits establish themselves during development are largely conserved across animal species. Connections made during embryonic…”
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Glial Derived TGF-β Instructs Axon Midline Stopping by Marmor-Kollet, Neta, Gutman, Itai, Issman-Zecharya, Noa, Schuldiner, Oren

“…A fundamental question that underlies the proper wiring and function of the nervous system is how axon extension stops during development. However, our…”
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Graded Expression of Semaphorin-1a Cell-Autonomously Directs Dendritic Targeting of Olfactory Projection Neurons by Komiyama, Takaki, Sweeney, Lora B., Schuldiner, Oren, Garcia, K. Christopher, Luo, Liqun

“…Gradients of axon guidance molecules instruct the formation of continuous neural maps, such as the retinotopic map in the vertebrate visual system. Here we…”
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Axon and dendrite pruning in Drosophila by Yu, Fengwei, Schuldiner, Oren

“…Highlights • Neuronal pruning is a widespread strategy crucial for refining the nervous systems. • MB γ and ddaC neurons are two attractive models for studying…”
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A DNA microarray screen for genes involved in c-MYC and N-MYC oncogenesis in human tumors by SCHULDINER, Oren, BENVENISTY, Nissim

“…MYC proto-oncogenes play a major role in various types of human tumors. The products of these genes are transcription factors that bind to specific sequences…”
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With a little help from my friends: how intercellular communication shapes neuronal remodeling by Meltzer, Hagar, Schuldiner, Oren

“…•Neurons undergoing developmental remodeling are part of a dynamic and complex tissue.•Interactions with cells such as neurons, glia and epidermal cells impact…”
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The PI3K Class III Complex Promotes Axon Pruning by Downregulating a Ptc-Derived Signal via Endosome-Lysosomal Degradation by Issman-Zecharya, Noa, Schuldiner, Oren

“…Developmental axon pruning is essential for wiring the mature nervous system, but its regulation remains poorly understood. Here we show that the…”
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Cut Your Losses: Spastin Mediates Branch-Specific Axon Loss by Meltzer, Hagar, Schuldiner, Oren

“…In this issue of Neuron, Brill et al. (2016) demonstrate that, during synapse elimination in the developing neuromuscular junction, branch-specific microtubule…”
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A computerized database-scan to identify c-MYC targets by Schuldiner, Oren, Shor, Sharon, Benvenisty, Nissim

“…The c-MYC oncogene plays a pivotal role in the malignant transformation of various types of human cancer. It is also a key regulator of cellular proliferation,…”
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