Search Results - "Schukur, Lina"

Sensing and responding to allergic response cytokines through a genetically encoded circuit by Chassin, Hélène, Geering, Barbara, Schukur, Lina, Ausländer, David, Lang, Brian, Fussenegger, Martin

“…While constantly rising, the prevalence of allergies is globally one of the highest among chronic diseases. Current treatments of allergic diseases include the…”
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Directed Differentiation of Size-Controlled Embryoid Bodies Towards Endothelial and Cardiac Lineages in RGD-Modified Poly(Ethylene Glycol) Hydrogels by Schukur, Lina, Zorlutuna, Pinar, Cha, Jae Min, Bae, Hojae, Khademhosseini, Ali

“…Recent advances in stem cell research have demonstrated the importance of microenvironmental cues in directing stem cell fate towards specific cell lineages…”
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DOT1L inhibition is lethal for multiple myeloma due to perturbation of the endoplasmic reticulum stress pathway by Dafflon, Caroline, Gaulis, Swann, Barys, Louise, Kapur, Karen, Cornacchione, Vanessa, Schukur, Lina, Bergling, Sebastian, Traggiai, Elisabetta, Jansky, Selina, Hellmann, Leon, Engstler, Barbara Schacher, Kerr, Grainne, de Weck, Antoine, Ruddy, David A, Naumann, Ulrike, Stauffer, Frédéric, Gaul, Christoph, Lin, Ying, Billy, Eric, Weiss, Andreas, Hofmann, Francesco, Ito, Moriko, Tiedt, Ralph

“…The histone 3 lysine 79 (H3K79) methyltransferase (HMT) DOT1L is known to play a critical role for growth and survival of -rearranged leukemia. Serendipitous…”
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Engineering of synthetic gene circuits for (re-)balancing physiological processes in chronic diseases by Schukur, Lina, Fussenegger, Martin

“…Synthetic biology is a promising multidisciplinary field that brings together experts in scientific disciplines from cell biology to engineering with the goal…”
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Implantable synthetic cytokine converter cells with AND-gate logic treat experimental psoriasis by Schukur, Lina, Geering, Barbara, Charpin-El Hamri, Ghislaine, Fussenegger, Martin

“…Psoriasis is a chronic inflammatory skin disease characterized by a relapsing-remitting disease course and correlated with increased expression of…”
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Human whole-blood culture system for ex vivo characterization of designer-cell function by Schukur, Lina, Geering, Barbara, Fussenegger, Martin

“…ABSTRACT Encapsulated designer cells implanted into mice are currently used to validate the efficacy of therapeutic gene networks for the diagnosis and…”
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Identification of the HECT E3 ligase UBR5 as a regulator of MYC degradation using a CRISPR/Cas9 screen by Schukur, Lina, Zimmermann, Tamara, Niewoehner, Ole, Kerr, Grainne, Gleim, Scott, Bauer-Probst, Beatrice, Knapp, Britta, Galli, Giorgio G., Liang, Xiaoyou, Mendiola, Angelica, Reece-Hoyes, John, Rapti, Melivoia, Barbosa, Ines, Reschke, Markus, Radimerski, Thomas, Thoma, Claudio R.

“…MYC oncoprotein is a multifunctional transcription factor that regulates the expression of a large number of genes involved in cellular growth, proliferation…”
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Reengineered carbonyl reductase for reducing methyl-substituted cyclohexanones by Jakoblinnert, Andre, Wachtmeister, Jochen, Schukur, Lina, Shivange, Amol V., Bocola, Marco, Ansorge-Schumacher, Marion B., Schwaneberg, Ulrich

“…The carbonyl reductase from Candida parapsilosis (CPCR2) is a versatile biocatalyst for the production of optically pure alcohols from ketones. Prochiral…”
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