The influence of anaesthesia on plasma spermidine concentration and renal excretion in rats

Anaesthesia with ether or a mixture of fentanyl and fluanisone diminished the clearance of infused spermidine from plasma in WAG/Rij rats considerably. The renal excretion of infused spermidine in unanaesthetized animals was only very small. The diminished plasma clearance of infused spermidine in a...

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Bibliographic Details
Published in:	Methods and findings in experimental and clinical pharmacology Vol. 8; no. 7; p. 431
Main Authors:	Driessen, O, Duyff, R F, Emonds, A, Luk, C M, Schuit, J C
Format:	Journal Article
Language:	English
Published:	Spain 01-07-1986
Subjects:	Anesthesia Animals Female Half-Life Kinetics Rats Rats, Inbred Strains Spermidine - blood Spermidine - metabolism Spermidine - urine
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Summary:	Anaesthesia with ether or a mixture of fentanyl and fluanisone diminished the clearance of infused spermidine from plasma in WAG/Rij rats considerably. The renal excretion of infused spermidine in unanaesthetized animals was only very small. The diminished plasma clearance of infused spermidine in anaesthetized animals therefore cannot be explained by loss of renal excretion.
ISSN:	0379-0355