Search Results - "Schuit, F. C"

Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet by Ehses, J. A, Meier, D. T, Wueest, S, Rytka, J, Boller, S, Wielinga, P. Y, Schraenen, A, Lemaire, K, Debray, S, Van Lommel, L, Pospisilik, J. A, Tschopp, O, Schultze, S. M, Malipiero, U, Esterbauer, H, Ellingsgaard, H, Rütti, S, Schuit, F. C, Lutz, T. A, Böni-Schnetzler, M, Konrad, D, Donath, Marc Y

“…Aims/hypothesis Inflammation contributes to both insulin resistance and pancreatic beta cell failure in human type 2 diabetes. Toll-like receptors (TLRs) are…”
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Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice by Lemaire, K, Ravier, M.A, Schraenen, A, Creemers, J.W.M, Van de Plas, R, Granvik, M, Van Lommel, L, Waelkens, E, Chimienti, F, Rutter, G.A, Gilon, P, Veld, P.A. in't, Schuit, F.C

“…Zinc co-crystallizes with insulin in dense core secretory granules, but its role in insulin biosynthesis, storage and secretion is unknown. In this study we…”
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Cluster analysis of rat pancreatic islet gene mRNA levels after culture in low-, intermediate- and high-glucose concentrations by Bensellam, M., Van Lommel, L., Overbergh, L., Schuit, F. C., Jonas, J. C.

“…Aims/hypothesis Survival and function of insulin-secreting pancreatic beta cells are markedly altered by changes in nutrient availability. In vitro, culture in…”
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Acute nutrient regulation of the unfolded protein response and integrated stress response in cultured rat pancreatic islets by ELOUIL, H, BENSELLAM, M, GUIOT, Y, VANDER MIERDE, D, PASCAL, S. M. A, SCHUIT, F. C, JONAS, J. C

“…Inadequate chaperone function relative to client protein load in the endoplasmic reticulum triggers an adaptive unfolded protein response (UPR), including the…”
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Anaplerosis via pyruvate carboxylase is required for the fuel-induced rise in the ATP:ADP ratio in rat pancreatic islets by FRANSSON, U, ROSENGREN, A. H, SCHUIT, F. C, RENSTRÖM, E, MULDER, H

“…The molecular mechanisms of insulin release are only partially known. Among putative factors for coupling glucose metabolism to insulin secretion, anaplerosis…”
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Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models by Viollet, B, Andreelli, F, Jørgensen, S B, Perrin, C, Flamez, D, Mu, J, Wojtaszewski, J F P, Schuit, F C, Birnbaum, M, Richter, E, Burcelin, R, Vaulont, S

“…AMP-activated protein kinase (AMPK) is viewed as a fuel sensor for glucose and lipid metabolism. To understand better the physiological role of the catalytic…”
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CTLA‐4 gene polymorphism confers susceptibility to insulin‐dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers by VAN DER AUWERA, B. J., VANDEWALLE, C. L., SCHUIT, F. C., WINNOCK, F., DE LEEUW, I. H., VAN IMSCHOOT, S., LAMBERIGTS, G., GORUS, F. K.

“…Apart from genes in the HLA complex (IDDM1) and the variable number of tandem repeats in the 5′ region of the insulin gene (INS VNTR, IDDM2), several other…”
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Male-to-female excess in diabetes diagnosed in early adulthood is not specific for the immune-mediated form nor is it HLA-DQ restricted : possible relation to increased body mass index by WEETS, I, VAN AUTREVE, J, DORCHY, H, QUARTIER, E, GORUS, F. K, VAN DER AUWERA, B. J, SCHUIT, F. C, DU CAJU, M. V. L, DECOCHEZ, K, DE LEEUW, I. H, KEYMEULEN, B, MATHIEU, C, ROTTIERS, R

“…AIMS/HYPOTHESIS. We investigated whether the reported HLA-DQ/DR restricted male-to-female (M:F) excess in Type I (insulin-dependent) diabetes mellitus also…”
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IA-2 autoantibodies predict impending Type I diabetes in siblings of patients by DECOCHEZ, K, DE LEEUW, I. H, PIPELEERS, D. G, GORUS, F. K, KEYMEULEN, B, MATHIEU, C, ROTTIERS, R, WEETS, I, VANDEMEULEBROUCKE, E, TRUYEN, I, KAUFMAN, L, SCHUIT, F. C

“…Multiple islet autoantibody positivity is currently believed to best predict progression to Type I (insulin-dependent) diabetes mellitus. We compared its…”
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Is GLUT2 required for glucose sensing ? by SCHUIT, F. C

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Glucose Stimulates Proinsulin Biosynthesis by a Dose-Dependent Recruitment of Pancreatic Beta Cells by Schuit, F. C., P. A. In't Veld, Pipeleers, D. G.

“…Glucose is a well-known stimulus of proinsulin biosynthesis. In purified beta cells, the sugar induces a 25-fold increase in the synthesis of insulin…”
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Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis by Schuit, Frans C, Kaufman, Randal J, Scheuner, Donalyn, Mierde, Dirk Vander, Song, Benbo, Flamez, Daisy, Creemers, John W M, Tsukamoto, Katsura, Ribick, Mark

“…Type 2 diabetes is a disorder of hyperglycemia resulting from failure of beta cells to produce adequate insulin to accommodate an increased metabolic demand…”
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Effects of chronically elevated glucose levels on the functional properties of rat pancreatic beta-cells by Ling, Z., Kiekens, R., Mahler, T., Schuit, F. C., Pipeleers-Marichal, M., Sener, A., Kloppel, G., Malaisse, W. J., Pipeleers, D. G.

“…Effects of chronically elevated glucose levels on the functional properties of rat pancreatic beta-cells. Z Ling , R Kiekens , T Mahler , F C Schuit , M…”
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Dehydroepiandrosterone sulfate and beta-cell function: enhanced glucose-induced insulin secretion and altered gene expression in rodent pancreatic beta-cells by DILLON, Joseph S, YANEY, Gordon C, WAXMAN, David J, CORKEY, Barbara E, YUANCHUN ZHOU, VOILLEY, Nicolas, BOWEN, Susan, CHIPKIN, Stuart, BLISS, Cheryl R, SCHULTZ, Vera, SCHUIT, Frans C, PRENTKI, Marc

“…Dehydroepiandrosterone sulfate and beta-cell function: enhanced glucose-induced insulin secretion and altered gene expression in rodent pancreatic beta-cells…”
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A new in vitro model for the study of pancreatic A and B cells by Pipeleers, D G, in't Veld, P A, Van de Winkel, M, Maes, E, Schuit, F C, Gepts, W

“…A method is developed for the preparation of single, pure, and viable rat pancreatic A and B cells in numbers sufficient for in vitro analysis. Islet isolation…”
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Regulation of adenosine 3',5'-monophosphate levels in the pancreatic B cell by Schuit, F C, Pipeleers, D G

“…The poor glucose-induced insulin release from single purified B cells has been attributed, in part, to the low cellular cAMP levels. The present study…”
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Glucose sensing in pancreatic β-cells: A model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus by SCHUIT, Frans C, HUYPENS, Peter, HEIMBERG, Harry, PIPELEERS, Daniel G

“…Nutrient homeostasis is known to be regulated by pancreatic islet tissue. The function of islet beta-cells is controlled by a glucose sensor that operates at…”
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Interplay of nutrients and hormones in the regulation of glucagon release by Pipeleers, D G, Schuit, F C, Van Schravendijk, C F, Van de Winkel, M

“…The role of nutrients and hormones in the regulation of glucagon release is investigated in pancreatic A cells purified by autofluorescence-activated cell…”
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Interplay of nutrients and hormones in the regulation of insulin release by Pipeleers, D G, Schuit, F C, in't Veld, P A, Maes, E, Hooghe-Peters, E L, Van de Winkel, M, Gepts, W

“…Single pancreatic B cells are purified by autofluorescence-activated cell sorting, and their secretory activity is measured after overnight culture. Compared…”
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Sensitivity of rat pancreatic A and B cells to somatostatin by SCHUIT, F. C, DERDE, M.-P, PIPELEERS, D. G

“…Islet A and B cells were purified from the rat pancreas and examined for their respective sensitivity to somatostatin. Both somatostatin-14 (S14) and -28 (S28)…”
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