Search Results - "Schuhmacher, J"

EGF Receptor Signaling Is Essential for K-Ras Oncogene-Driven Pancreatic Ductal Adenocarcinoma by Navas, Carolina, Hernández-Porras, Isabel, Schuhmacher, Alberto J., Sibilia, Maria, Guerra, Carmen, Barbacid, Mariano

“…Clinical evidence indicates that mutation/activation of EGF receptors (EGFRs) is mutually exclusive with the presence of K-RAS oncogenes in lung and colon…”
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The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas by Quail, Daniela F., Bowman, Robert L., Akkari, Leila, Quick, Marsha L., Schuhmacher, Alberto J., Huse, Jason T., Holland, Eric C., Sutton, James C., Joyce, Johanna A.

“…Macrophages accumulate with glioblastoma multiforme (GBM) progression and can be targeted via inhibition of colony-stimulating factor-1 receptor (CSF-1R) to…”
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Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence by Guerra, Carmen, Collado, Manuel, Navas, Carolina, Schuhmacher, Alberto J., Hernández-Porras, Isabel, Cañamero, Marta, Rodriguez-Justo, Manuel, Serrano, Manuel, Barbacid, Mariano

“…Pancreatic acinar cells of adult mice (≥P60) are resistant to transformation by some of the most robust oncogenic insults including expression of K- Ras…”
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Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas by Yan, D, Kowal, J, Akkari, L, Schuhmacher, A J, Huse, J T, West, B L, Joyce, J A

“…Glioblastomas represent the most aggressive glioma grade and are associated with a poor patient prognosis. The current standard of care, consisting of surgery,…”
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Nitrogen-free sol–gel synthesis of Al-substituted cubic garnet Li7La3Zr2O12 (LLZO) by Rosenkiewitz, N., Schuhmacher, J., Bockmeyer, M., Deubener, J.

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CSF-1R inhibition alters macrophage polarization and blocks glioma progression by Pyonteck, Stephanie M, Akkari, Leila, Schuhmacher, Alberto J, Bowman, Robert L, Sevenich, Lisa, Quail, Daniela F, Olson, Oakley C, Quick, Marsha L, Huse, Jason T, Teijeiro, Virginia, Setty, Manu, Leslie, Christina S, Oei, Yoko, Pedraza, Alicia, Zhang, Jianan, Brennan, Cameron W, Sutton, James C, Holland, Eric C, Daniel, Dylan, Joyce, Johanna A

“…The authors provide preclinical testing of a CSFR-1 inhibitor in proneural glioma models. The compound targets macrophages in the tumor microenvironment rather…”
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Transportation of Single-Domain Antibodies through the Blood–Brain Barrier by Ruiz-López, Eduardo, Schuhmacher, Alberto J.

“…Single-domain antibodies derive from the heavy-chain-only antibodies of Camelidae (camel, dromedary, llama, alpaca, vicuñas, and guananos; i.e., nanobodies)…”
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Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice by Guerra, Carmen, Schuhmacher, Alberto J., Cañamero, Marta, Grippo, Paul J., Verdaguer, Lena, Pérez-Gallego, Lucía, Dubus, Pierre, Sandgren, Eric P., Barbacid, Mariano

“…Pancreatic ductal adenocarcinoma (PDA), one of the deadliest human cancers, often involves somatic activation of K- Ras oncogenes. We report that selective…”
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Spheresomes are the main extracellular vesicles in low-grade gliomas by Baselga, Marta, Iruzubieta, Pablo, Castiella, Tomás, Monzón, Marta, Monleón, Eva, Berga, Carmen, Schuhmacher, Alberto J., Junquera, Concepción

“…Cancer progression and its impact on treatment response and prognosis is deeply regulated by tumour microenvironment (TME). Cancer cells are in constant…”
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Nanobodies targeting ABCC3 for immunotargeted applications in glioblastoma by Ruiz-López, Eduardo, Jovčevska, Ivana, González-Gómez, Ruth, Tejero, Héctor, Al-Shahrour, Fátima, Muyldermans, Serge, Schuhmacher, Alberto J.

“…The cancer “omics” reveal many clinically relevant alterations that are transforming the molecular characterization of glioblastomas. However, many of these…”
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Targeting MT1-MMP as an ImmunoPET-Based Strategy for Imaging Gliomas by de Lucas, A G, Schuhmacher, A J, Oteo, M, Romero, E, Cámara, J A, de Martino, A, Arroyo, A G, Morcillo, M Á, Squatrito, M, Martinez-Torrecuadrada, J L, Mulero, F

“…A critical challenge in the management of Glioblastoma Multiforme (GBM) tumors is the accurate diagnosis and assessment of tumor progression in a noninvasive…”
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K-Rasⱽ¹⁴ᴵ recapitulates Noonan syndrome in mice by Hernández-Porras, Isabel, Fabbiano, Salvatore, Schuhmacher, Alberto J, Aicher, Alexandra, Cañamero, Marta, Cámara, Juan Antonio, Cussó, Lorena, Desco, Manuel, Heeschen, Christopher, Mulero, Francisca, Bustelo, Xosé R, Guerra, Carmen, Barbacid, Mariano

“…Significance Noonan syndrome (NS) is a developmental disorder caused by germ-line mutations in various components of the RAS signaling pathway. The…”
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Mechanisms underlying cognitive deficits in a mouse model for Costello Syndrome are distinct from other RASopathy mouse models by Schreiber, Jadwiga, Grimbergen, Laura-Anne, Overwater, Iris, Vaart, Thijs van der, Stedehouder, Jeffrey, Schuhmacher, Alberto J., Guerra, Carmen, Kushner, Steven A., Jaarsma, Dick, Elgersma, Ype

“…RASopathies, characterized by germline mutations in genes encoding proteins of the RAS-ERK signaling pathway, show overlapping phenotypes, which manifest…”
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Tumour biology Senescence in premalignant tumours by Serrano, Manuel, Collado, Manuel, Gil, Jesús, Efeyan, Alejo, Guerra, Carmen, Schuhmacher, Alberto J, Barradas, Marta, Benguría, Alberto, Zaballos, Angel, Flores, Juana M, Barbacid, Mariano, Beach, David

“…Oncogene-induced senescence is a cellular response that may be crucial for protection against cancer development, but its investigation has so far been…”
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Planning of Available Resources Considering Ergonomics Under Deterministic Highly Variable Demand by Bonini, M., Schuhmacher, J., Urru, A., Wezel, J. P., Hummel, V., Echelmeyer, W.

“…In this paper, a method for hybrid short- to long-term planning of available resources for operations is presented, which is based on a known or…”
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Glioblastoma and glioblastoma stem cells are dependent on functional MTH1 by Pudelko, Linda, Rouhi, Pegah, Sanjiv, Kumar, Gad, Helge, Kalderén, Christina, Höglund, Andreas, Squatrito, Massimo, Schuhmacher, Alberto J, Edwards, Steven, Hägerstrand, Daniel, Berglund, Ulrika Warpman, Helleday, Thomas, Bräutigam, Lars

“…Glioblastoma multiforme (GBM) is an aggressive form of brain cancer with poor prognosis. Cancer cells are characterized by a specific redox environment that…”
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Development and Validation of a Methodology to Measure Exhaled Carbon Dioxide (CO2) and Control Indoor Air Renewal by Baselga, Marta, Alba, Juan J., Schuhmacher, Alberto J.

“…The measurement of carbon dioxide (CO2) has emerged as a cost-effective and straightforward technique for indirectly managing indoor air quality, aiding in the…”
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PET imaging of somatostatin receptors using [(68)GA]DOTA-D-Phe(1)-Tyr(3)-octreotide: First results in patients with meningiomas by Henze, Marcus, Schuhmacher, Jochen, Hipp, Peter, Kowalski, Jorg

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Impact of needle-point bipolar ionization system in the reduction of bioaerosols in collective transport by Baselga, Marta, Alba, Juan J., Schuhmacher, Alberto J.

“…The transmission rate of SARS-CoV-2 is higher in collective transport than in other public environments. Transport companies require preventive strategies to…”
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Correction: Glioblastoma and glioblastoma stem cells are dependent on functional MTH1 by Pudelko, Linda, Rouhi, Pegah, Sanjiv, Kumar, Gad, Helge, Kalderén, Christina, Höglund, Andreas, Squatrito, Massimo, Schuhmacher, Alberto J, Edwards, Steven, Hägerstrand, Daniel, Berglund, Ulrika Warpman, Helleday, Thomas, Bräutigam, Lars

“…[This corrects the article DOI: 10.18632/oncotarget.19404.]…”
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