Search Results - "Schuh, Rosemary A."

Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer's disease-relevant murine model by Long, Aaron N, Owens, Katrina, Schlappal, Anna E, Kristian, Tibor, Fishman, Paul S, Schuh, Rosemary A

“…Mitochondrial dysfunction is a hallmark of neurodegenerative diseases including Alzheimer's disease (AD), with morphological and functional abnormalities…”
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Sex‐dependent mitochondrial respiratory impairment and oxidative stress in a rat model of neonatal hypoxic‐ischemic encephalopathy by Demarest, Tyler G., Schuh, Rosemary A., Waddell, Jaylyn, McKenna, Mary C., Fiskum, Gary

“…Increased male susceptibility to long‐term cognitive deficits is well described in clinical and experimental studies of neonatal hypoxic‐ischemic…”
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An exploratory investigation of brain-selective estrogen treatment in males using a mouse model of Alzheimer's disease by Tschiffely, Anna E., Schuh, Rosemary A., Prokai-Tatrai, Katalin, Ottinger, Mary Ann, Prokai, Laszlo

“…Estrogens are neuroprotective, and studies suggest that they may mitigate the pathology and symptoms of Alzheimer's disease (AD) in female models. However,…”
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Platelets in preeclamptic pregnancies fail to exhibit the decrease in mitochondrial oxygen consumption rate seen in normal pregnancies by Malinow, Andrew M, Schuh, Rosemary A, Alyamani, Omar, Kim, Joseph, Bharadwaj, Shobana, Crimmins, Sarah D, Galey, Jessica L, Fiskum, Gary, Polster, Brian M

“…Cellular oxygen consumption and lactate production rates have been measured in both placental and myometrial cells to study obstetrics-related disease states…”
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BRCA1 is a novel regulator of metabolic function in skeletal muscle by Jackson, Kathryn C., Gidlund, Eva-Karin, Norrbom, Jessica, Valencia, Ana P., Thomson, David M., Schuh, Rosemary A., Neufer, P. Darrell, Spangenburg, Espen E.

“…Breast cancer type 1 (BRCA1) susceptibility protein is expressed across multiple tissues including skeletal muscle. The overall objective of this investigation…”
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Ectopic lipid deposition and the metabolic profile of skeletal muscle in ovariectomized mice by Jackson, Kathryn C, Wohlers, Lindsay M, Lovering, Richard M, Schuh, Rosemary A, Maher, Amy C, Bonen, Arend, Koves, Timothy R, Ilkayeva, Olga, Thomson, David M, Muoio, Deborah M, Spangenburg, Espen E

“…Disruptions of ovarian function in women are associated with increased risk of metabolic disease due to dysregulation of peripheral glucose homeostasis in…”
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Mitochondrial oxygen consumption deficits in skeletal muscle isolated from an Alzheimer's disease-relevant murine model by Schuh, Rosemary A, Jackson, Kathryn C, Schlappal, Anna E, Spangenburg, Espen E, Ward, Christopher W, Park, Ji H, Dugger, Natalie, Shi, Guo Li, Fishman, Paul S

“…Age is considered a primary risk factor for neurodegenerative diseases including Alzheimer's disease (AD). It is also now well understood that mitochondrial…”
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A comparative evaluation of treatments with 17β-estradiol and its brain-selective prodrug in a double-transgenic mouse model of Alzheimer's disease by Tschiffely, Anna E., Schuh, Rosemary A., Prokai-Tatrai, Katalin, Prokai, Laszlo, Ottinger, Mary Ann

“…Estrogens are neuroprotective and, thus, potentially useful for the therapy of Alzheimer's disease; however, clinical use of hormone therapy remains…”
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Measuring mitochondrial respiration in intact single muscle fibers by Schuh, Rosemary A, Jackson, Kathryn C, Khairallah, Ramzi J, Ward, Christopher W, Spangenburg, Espen E

“…Measurement of mitochondrial function in skeletal muscle is a vital tool for understanding regulation of cellular bioenergetics. Currently, a number of…”
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Adaptation of microplate-based respirometry for hippocampal slices and analysis of respiratory capacity by Schuh, Rosemary A., Clerc, Pascaline, Hwang, Hyehyun, Mehrabian, Zara, Bittman, Kevin, Chen, Hegang, Polster, Brian M.

“…Multiple neurodegenerative disorders are associated with altered mitochondrial bioenergetics. Although mitochondrial O2 consumption is frequently measured in…”
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Postnatal developmental regulation of Bcl-2 family proteins in brain mitochondria by Soane, Lucian, Siegel, Zachary T., Schuh, Rosemary A., Fiskum, Gary

“…Although it has been long recognized that the relative balance of pro‐ and antiapoptotic Bcl‐2 proteins is critical in determining the susceptibility to…”
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AICAR inhibits oxygen consumption by intact skeletal muscle cells in culture by Spangenburg, Espen E., Jackson, Kathryn C., Schuh, Rosemary A.

“…Activation of 5′ adenosine monophosphate-activated protein kinase (AMPK) with aminoimidazole carboxamide ribonucleotide (AICAR) increases skeletal muscle…”
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Effects of the organochlorine pesticide methoxychlor on dopamine metabolites and transporters in the mouse brain by Schuh, Rosemary A., Richardson, Jason R., Gupta, Rupesh K., Flaws, Jodi A., Fiskum, Gary

“…Pesticide exposure has been suggested as a risk factor in developing Parkinson's disease (PD). While the molecular mechanism underlying this association is not…”
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Interaction of mitochondrial respiratory inhibitors and excitotoxins potentiates cell death in hippocampal slice cultures by Schuh, Rosemary A., Matthews, Christopher C., Fishman, Paul S.

“…The broad‐spectrum insecticide rotenone, an inhibitor of complex I of the mitochondrial electron transport chain (ETC), gives rise to oxidative stress and…”
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Methoxychlor Inhibits Brain Mitochondrial Respiration and Increases Hydrogen Peroxide Production and CREB Phosphorylation by Schuh, Rosemary A., Kristián, Tibor, Gupta, Rupesh K., Flaws, Jodi A., Fiskum, Gary

“…The organochlorine insecticide methoxychlor (mxc) is an established reproductive toxicant that affects other systems including the central nervous system…”
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Calcium‐dependent dephosphorylation of brain mitochondrial calcium/cAMP response element binding protein (CREB) by Schuh, Rosemary A., Kristián, Tibor, Fiskum, Gary

“…Calcium‐mediated signaling regulates nuclear gene transcription by calcium/cAMP response element binding protein (CREB) via calcium‐dependent kinases and…”
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A comparative evaluation of treatments with 17[beta]-estradiol and its brain-selective prodrug in a double-transgenic mouse model of Alzheimer's disease by Tschiffely, Anna E, Schuh, Rosemary A, Prokai-Tatrai, Katalin, Prokai, Laszlo, Ottinger, Mary Ann

“…Estrogens are neuroprotective and, thus, potentially useful for the therapy of Alzheimer's disease; however, clinical use of hormone therapy remains…”
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Noncholinesterase mechanisms of chlorpyrifos neurotoxicity: Altered phosphorylation of Ca2+/cAMP response element binding protein in cultured neurons by SCHUH, Rosemary A, LEIN, Pamela J, BECKLES, Rondell A, JETT, David A

“…Previous studies suggest that low doses of the organophosphate insecticide chlorpyrifos (CPF) disrupt brain development and cognitive function by mechanisms…”
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Noncholinesterase Mechanisms of Chlorpyrifos Neurotoxicity: Altered Phosphorylation of Ca 2+/cAMP Response Element Binding Protein in Cultured Neurons by Schuh, Rosemary A., Lein, Pamela J., Beckles, Rondell A., Jett, David A.

“…Previous studies suggest that low doses of the organophosphate insecticide chlorpyrifos (CPF) disrupt brain development and cognitive function by mechanisms…”
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