Search Results - "Schuetz, John"

Obstacles to Brain Tumor Therapy: Key ABC Transporters by Wijaya, Juwina, Fukuda, Yu, Schuetz, John D

“…The delivery of cancer chemotherapy to treat brain tumors remains a challenge, in part, because of the inherent biological barrier, the blood-brain barrier…”
Get full text

“OMICs” reveal the molecular basis of a rare blood group by Schuetz, John D.

“…Blood groups are defined by membrane proteins that are either single-pass, multi-pass, or glycosylphosphatidylinositol-linked proteins. The antigens defining…”
Get full text

ABC transporters and their role in nucleoside and nucleotide drug resistance by Fukuda, Yu, Schuetz, John D.

“…ATP-binding cassette (ABC) transporters confer drug resistance against a wide range of chemotherapeutic agents, including nucleoside and nucleotide based…”
Get full text

Using Pharmacology to Squeeze the Life Out of Childhood Leukemia, and Potential Strategies to Achieve Breakthroughs in Medulloblastoma Treatment by Wijaya, Juwina, Gose, Tomoka, Schuetz, John D

“…Eliminating cancer was once thought of as a war. This analogy is still apt today; however, we now realize that cancer is a much more formidable enemy than…”
Get full text

How Cryo-EM Has Expanded Our Understanding of Membrane Transporters by Baril, Stefanie A, Gose, Tomoka, Schuetz, John D

“…Over the past two decades, technological advances in membrane protein structural biology have provided insight into the molecular mechanisms that transporters…”
Get full text

Beyond Competitive Inhibition: Regulation of ABC Transporters by Kinases and Protein-Protein Interactions as Potential Mechanisms of Drug-Drug Interactions by Crawford, Rebecca R, Potukuchi, Praveen K, Schuetz, Erin G, Schuetz, John D

“…ATP-binding cassette (ABC) transporters are transmembrane efflux transporters mediating the extrusion of an array of substrates ranging from amino acids and…”
Get full text

Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction by Wang, Xi, Bathina, Madhavi, Lynch, John, Koss, Brian, Calabrese, Christopher, Frase, Sharon, Schuetz, John D, Rehg, Jerold E, Opferman, Joseph T

“…MCL-1 is an essential BCL-2 family member that promotes the survival of multiple cellular lineages, but its role in cardiac muscle has remained unclear. Here,…”
Get full text

Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters by Ganguly, Samit, Finkelstein, David, Shaw, Timothy I, Michalek, Ryan D, Zorn, Kimberly M, Ekins, Sean, Yasuda, Kazuto, Fukuda, Yu, Schuetz, John D, Mukherjee, Kamalika, Schuetz, Erin G

“…Abcg2/Bcrp and Abcb1a/Pgp are xenobiotic efflux transporters limiting substrate permeability in the gastrointestinal system and brain, and increasing renal and…”
Get full text

Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration by Perciavalle, Rhonda M., Stewart, Daniel P., Koss, Brian, Lynch, John, Milasta, Sandra, Bathina, Madhavi, Temirov, Jamshid, Cleland, Megan M., Pelletier, Stéphane, Schuetz, John D., Youle, Richard J., Green, Douglas R., Opferman, Joseph T.

“…MCL-1, an anti-apoptotic BCL-2 family member that is essential for the survival of multiple cell lineages, is also among the most highly amplified genes in…”
Get full text

ABCB6, an ABC Transporter Impacting Drug Response and Disease by Boswell-Casteel, Rebba C., Fukuda, Yu, Schuetz, John D.

“…Recent findings have discovered how insufficiency of ATP-binding cassette (ABC) transporter, ABCB6, can negatively impact human health. These advances were…”
Get full text

Investigation of the Importance of Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4) in the Active Efflux of Anionic Drugs Across the Blood-Brain Barrier by Kanamitsu, Kayoko, Kusuhara, Hiroyuki, Schuetz, John D, Takeuchi, Kenji, Sugiyama, Yuichi

“…The importance of multidrug resistance-associated protein 4 (Mrp4/Abcc4) in limiting the penetration of Mrp4 substrate compounds into the central nervous…”
Get more information

The role of ABCG2 and ABCB6 in porphyrin metabolism and cell survival by Krishnamurthy, Partha, Schuetz, John D

“…The porphyrins (such as heme) are essential molecules within cells and have multiple roles in essential cellular processes such as: the mitochondrial electron…”
Get more information

ABCG2 requires a single aromatic amino acid to “clamp” substrates and inhibitors into the binding pocket by Gose, Tomoka, Shafi, Talha, Fukuda, Yu, Das, Sourav, Wang, Yao, Allcock, Alice, Gavan McHarg, Ailsa, Lynch, John, Chen, Taosheng, Tamai, Ikumi, Shelat, Anang, Ford, Robert C., Schuetz, John D.

“…ATP‐binding cassette sub‐family G member 2 (ABCG2) is a homodimeric ATP‐binding cassette (ABC) transporter that not only has a key role in helping cancer cells…”
Get full text

Publisher Correction: The net electrostatic potential and hydration of ABCG2 affect substrate transport by Gose, Tomoka, Aitken, Heather M., Wang, Yao, Lynch, John, Rampersaud, Evadnie, Fukuda, Yu, Wills, Medb, Baril, Stefanie A., Ford, Robert C., Shelat, Anang, O’Mara, Megan L., Schuetz, John D.

Get full text

Development and validation of an LC-MS/MS method to quantify the bromodomain and extra-terminal (BET) inhibitor JQ1 in mouse plasma and brain microdialysate: Application to cerebral microdialysis study by Nair, Sreenath, Davis, Abigail, Campagne, Olivia, Schuetz, John D., Stewart, Clinton F.

“…•Developed and validated novel LC–MS/MS method for JQ1 in mouse plasma in dialysate.•Method utilized HLB uElution plate-based extraction method for sample…”
Get full text

Zebrafish abcb11b mutant reveals strategies to restore bile excretion impaired by bile salt export pump deficiency by Ellis, Jillian L., Bove, Kevin E., Schuetz, Erin G., Leino, Daniel, Valencia, C. Alexander, Schuetz, John D., Miethke, Alexander, Yin, Chunyue

“…Bile salt export pump (BSEP) adenosine triphosphate–binding cassette B11 (ABCB11) is a liver‐specific ABC transporter that mediates canalicular bile salt…”
Get full text

Development and Validation of a Sensitive and Specific LC-MS/MS Method for IWR-1-Endo, a Wnt Signaling Inhibitor: Application to a Cerebral Microdialysis Study by Nair, Sreenath, Davis, Abigail, Campagne, Olivia, Schuetz, John D, Stewart, Clinton F

“…IWR-1-endo, a small molecule that potently inhibits the Wnt/β-catenin signaling pathway by stabilizing the AXIN2 destruction complex, can inhibit drug efflux…”
Get full text

An ABC transporter as a potential target against SHH-Medulloblastoma: From Benchtop to Bedside by Zhu, Jingwen, Miller, Joseph N., Schuetz, John D.

Get full text

Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir by Imaoka, Tomoki, Kusuhara, Hiroyuki, Adachi, Masashi, Schuetz, John D, Takeuchi, Kenji, Sugiyama, Yuichi

“…Acyclic nucleotide phosphonates (adefovir, cidofovir, and tenofovir) are eliminated predominantly into the urine, and renal failure is their dose-limiting…”
Get more information

Dynamic Changes in ABCC4 Protein‐Protein Interactions during PKA Signaling: Role of the ABCC4 PDZ Motif by Ranjit, Sabina, Zhu, Jingwen, Pitre, Aaron, Wang, Yao, Crawford, Rebecca, Nourse, Amanda, Li, Yuxin, Pagala, Vishwajeeth, Peng, Junmin, Schuetz, John D.

“…We recently demonstrated that a protein interaction between the PDZ motif of ABCC4 and a single PDZ‐domain‐containing protein, MPP1 had an important role in…”
Get full text