Search Results - "Schuchardt, J"

Enhanced increase of omega-3 index in response to long-term n-3 fatty acid supplementation from triacylglycerides versus ethyl esters by Neubronner, J, Schuchardt, J.P, Kressel, G, Merkel, M, Schacky, C. von, Hahn, A

“…Background: There is a debate currently about whether different chemical forms of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are absorbed in an…”
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Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation by Bitsch, A, Schuchardt, J, Bunkowski, S, Kuhlmann, T, Brück, W

“…Damage to axons is taken as a key factor of disability in multiple sclerosis, but its pathogenesis is largely unknown. Axonal injury is believed to occur as a…”
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A combination of palm oil tocotrienols and citrus peel polymethoxylated flavones does not influence elevated LDL cholesterol and high-sensitivity C-reactive protein levels by Schuchardt, J P, Heine, S, Hahn, A

“…Background/Objectives: Lipid-lowering and anti-inflammatory effects have been individually described for tocotrienols (TTs) and polymethoxylated flavones…”
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Moderate doses of EPA and DHA from re-esterified triacylglycerols but not from ethyl-esters lower fasting serum triacylglycerols in statin-treated dyslipidemic subjects: Results from a six month randomized controlled trial by Schuchardt, J.P, Neubronner, J, Kressel, G, Merkel, M, von Schacky, C, Hahn, A

“…Abstract Recently, in a supplementation study over six months, it has been demonstrated that re-esterified omega-3 fatty acid triacylglycerols (n3-FA-rTAGs)…”
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Genetic variants of the FADS gene cluster are associated with erythrocyte membrane LC PUFA levels in patients with mild cognitive impairment by Schuchardt, Jan Philipp, Köbe, T., Witte, V., Willers, J., Gingrich, A., Tesky, V., Pantel, J., Rujescu, D., Illig, T., Flöel, A., Hahn, A.

“…Background Long-chain (> 20 C-atoms) polyunsaturated fatty acids (LC PUFAs) of both the omega-6 (n-6) and omega-3 (n-3) series are important for the functional…”
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Interplay between HGAL and Grb2 proteins regulates B-cell receptor signaling by Jiang, Xiaoyu, Lu, Xiaoqing, Zhang, Yu, Lacaria, Leda, Schuchardt, Brett J., Mikles, David C., Magistri, Marco, García-Ramírez, Idoia, Sanchez-Garcia, Isidro, Farooq, Amjad, Verdun, Ramiro E., Abdulreda, Midhat H., Moy, Vincent T., Lossos, Izidore S.

“…Human germinal center (GC)–associated lymphoma (HGAL) is an adaptor protein expressed in GC B cells. HGAL regulates cell motility and B-cell receptor (BCR)…”
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Molecular Origin of the Binding of WWOX Tumor Suppressor to ErbB4 Receptor Tyrosine Kinase by Schuchardt, Brett J, Bhat, Vikas, Mikles, David C, McDonald, Caleb B, Sudol, Marius, Farooq, Amjad

“…The ability of WWOX tumor suppressor to physically associate with the intracellular domain (ICD) of ErbB4 receptor tyrosine kinase is believed to play a…”
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Molecular basis of the binding of YAP transcriptional regulator to the ErbB4 receptor tyrosine kinase by Schuchardt, Brett J., Bhat, Vikas, Mikles, David C., McDonald, Caleb B., Sudol, Marius, Farooq, Amjad

“…The newly discovered transactivation function of ErbB4 receptor tyrosine kinase is believed to be mediated by virtue of the ability of its…”
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Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity by Schuchardt, Brett J, Mikles, David C, Hoang, Lawrence M, Bhat, Vikas, McDonald, Caleb B, Sudol, Marius, Farooq, Amjad

“…YES‐associated protein 2 (YAP2) transcriptional regulator drives a multitude of cellular processes, including the newly discovered Hippo tumor suppressor…”
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Effect of osmolytes on the binding of EGR1 transcription factor to DNA by Mikles, David C., Bhat, Vikas, Schuchardt, Brett J., McDonald, Caleb B., Farooq, Amjad

“…ABSTRACT Osmolytes play a key role in maintaining protein stability and mediating macromolecular interactions within the intracellular environment of the cell…”
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pH modulates the binding of early growth response protein 1 transcription factor to DNA by Mikles, David C., Bhat, Vikas, Schuchardt, Brett J., Deegan, Brian J., Seldeen, Kenneth L., McDonald, Caleb B., Farooq, Amjad

“…The transcription factor early growth response protein (EGR)1 orchestrates a plethora of signaling cascades involved in cellular homeostasis, and its…”
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Helix 8 and the i3 Loop of the Muscarinic M3 Receptor Are Crucial Sites for Its Regulation by the Gβ5-RGS7 Complex by Karpinsky-Semper, Darla, Tayou, Junior, Levay, Konstantin, Schuchardt, Brett J, Bhat, Vikas, Volmar, Claude-Henry, Farooq, Amjad, Slepak, Vladlen Z

“…The muscarinic M3 receptor (M3R) is a Gq-coupled receptor and is known to interact with many intracellular regulatory proteins. One of these molecules is…”
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Role of promoter DNA sequence variations on the binding of EGR1 transcription factor by Mikles, David C., Schuchardt, Brett J., Bhat, Vikas, McDonald, Caleb B., Farooq, Amjad

“…[Display omitted] •Nucleotide substitutions tightly modulate the binding of EGR1 to DNA.•EGR1–DNA interaction is more susceptible to sequence variations at…”
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Molecular determinants of the binding specificity of BH3 ligands to BclXL apoptotic repressor by Bhat, Vikas, Olenick, Max B., Schuchardt, Brett J., Mikles, David C., McDonald, Caleb B., Farooq, Amjad

“…ABSTRACT B‐cell lymphoma extra‐large protein (BclXL) serves as an apoptotic repressor by virtue of its ability to recognize and bind to BH3 domains found…”
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Allostery mediates ligand binding to WWOX tumor suppressor via a conformational switch by Schuchardt, Brett J., Mikles, David C., Bhat, Vikas, McDonald, Caleb B., Sudol, Marius, Farooq, Amjad

“…While being devoid of the ability to recognize ligands itself, the WW2 domain is believed to aid ligand binding to the WW1 domain in the context of a WW1–WW2…”
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Biophysical basis of the promiscuous binding of B-cell lymphoma protein 2 apoptotic repressor to BH3 ligands by Bhat, Vikas, Olenick, Max B., Schuchardt, Brett J., Mikles, David C., McDonald, Caleb B., Farooq, Amjad

“…B‐cell lymphoma protein 2 (Bcl2) apoptotic repressor carries out its function by virtue of its ability to bind to BH3 domains of various pro‐apoptotic…”
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Enthalpic factors override the polyelectrolyte effect in the binding of EGR1 transcription factor to DNA by Mikles, David C., Bhat, Vikas, Schuchardt, Brett J., McDonald, Caleb B., Farooq, Amjad

“…Protein–DNA interactions are highly dependent upon salt such that the binding affinity precipitously decreases with increasing salt concentration in a…”
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Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time by Kuhlmann, Tanja, Lingfeld, Gueanelle, Bitsch, Andreas, Schuchardt, Jana, Brück, Wolfgang

“…Multiple sclerosis is characterized morphologically by the key features demyelination, inflammation, gliosis and axonal damage. In recent years, it has become…”
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Heat-induced fibrillation of BclXL apoptotic repressor by Bhat, Vikas, Olenick, Max B., Schuchardt, Brett J., Mikles, David C., Deegan, Brian J., McDonald, Caleb B., Seldeen, Kenneth L., Kurouski, Dmitry, Faridi, Mohd Hafeez, Shareef, Mohammed M., Gupta, Vineet, Lednev, Igor K., Farooq, Amjad

“…The BclXL apoptotic repressor bears the propensity to associate into megadalton oligomers in solution, particularly under acidic pH. Herein, using various…”
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The Prevalence of Perioperative Nurse Clinical Judgments by Killen, A.R., Kleinbeck, S.V.M., Golar, K., Schuchardt, J. Takahashi, Uebele, J.

“…A clinical judgment about a patient situation precedes the selection of appropriate nursing actions and the identification of patient outcomes. The North…”
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