Search Results - "Schubot, Florian D."

Crystal Structure of a Type IV Pilus Assembly ATPase: Insights into the Molecular Mechanism of PilB from Thermus thermophilus by Mancl, Jordan M., Black, Wesley P., Robinson, Howard, Yang, Zhaomin, Schubot, Florian D.

“…Type IV pili (T4P) mediate bacterial motility and virulence. The PilB/GspE family ATPases power the assembly of T4P and type 2 secretion systems. We determined…”
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The structural analysis of the periplasmic domain of Sinorhizobium meliloti chemoreceptor McpZ reveals a novel fold and suggests a complex mechanism of transmembrane signaling by Salar, Safoura, Ball, Nicolas E, Baaziz, Hiba, Nix, Jay C, Sobe, Richard C, Compton, K Karl, Zhulin, Igor B, Brown, Anne M, Scharf, Birgit E, Schubot, Florian D

“…Chemotaxis is a fundamental process whereby bacteria seek out nutrient sources and avoid harmful chemicals. For the symbiotic soil bacterium Sinorhizobium…”
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Structural Analysis of the Regulatory Domain of ExsA, a Key Transcriptional Regulator of the Type Three Secretion System in Pseudomonas aeruginosa by Shrestha, Manisha, Xiao, Yi, Robinson, Howard, Schubot, Florian D

“…Pseudomonas aeruginosa employs a type three secretion system to facilitate infections in mammalian hosts. The operons encoding genes of structural components…”
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The type IV pilus assembly ATPase PilB functions as a signaling protein to regulate exopolysaccharide production in Myxococcus xanthus by Black, Wesley P., Wang, Lingling, Jing, Xing, Saldaña, Rafael Castañeda, Li, Feng, Scharf, Birgit E., Schubot, Florian D., Yang, Zhaomin

“…Myxococcus xanthus possesses a form of surface motility powered by the retraction of the type IV pilus (T4P). Additionally, exopolysaccharide (EPS), the major…”
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Phosphorylation and Dephosphorylation among Dif Chemosensory Proteins Essential for Exopolysaccharide Regulation in Myxococcus xanthus by Black, Wesley P, Schubot, Florian D, Li, Zhuo, Yang, Zhaomin

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Orientation of Pseudomonas aeruginosa ExsA Monomers Bound to Promoter DNA and Base-Specific Contacts with the PexoT Promoter by King, Jessica M, Brutinel, Evan D, Marsden, Anne E, Schubot, Florian D, Yahr, Timothy L

“…ExsA is a transcriptional activator of the Pseudomonas aeruginosa type III secretion system (T3SS) and a member of the AraC/XylS protein family. Each of the 10…”
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Structure of the POZ domain of human LRF, a master regulator of oncogenesis by Schubot, Florian D., Tropea, Joseph E., Waugh, David S.

“…The proto-oncogenic properties of the POK family of transcriptional repressors BCL6, PLZF, and LRF have been well established. These proteins utilize their…”
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RetS inhibits Pseudomonas aeruginosa biofilm formation by disrupting the canonical histidine kinase dimerization interface of GacS by Ryan Kaler, Kylie M., Nix, Jay C., Schubot, Florian D.

“…Bacterial signaling histidine kinases (HKs) have long been postulated to function exclusively through linear signal transduction chains. However, several HKs…”
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Helix Cracking Regulates the Critical Interaction between RetS and GacS in Pseudomonas aeruginosa by Mancl, Jordan M., Ray, William K., Helm, Rich F., Schubot, Florian D.

“…Recent paradigm shifting discoveries have demonstrated that bacterial signaling kinases engage in unexpected regulatory crosstalk, yet the underlying molecular…”
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Biochemical analysis of protein-protein interfaces underlying the regulation of bacterial secretion systems by Salar, Safoura, Schubot, Florian D

“…Bacterial pathogens such as Pseudomonas aeruginosa use complex regulatory networks to tailor gene expression patterns to meet complex environmental challenges…”
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Structural Basis for the Exocellulase Activity of the Cellobiohydrolase CbhA from Clostridium thermocellum by Schubot, Florian D, Kataeva, Irina A, Chang, Jessie, Shah, Ashit K, Ljungdahl, Lars G, Rose, John P, Wang, Bi-Cheng

“…Numerous bacterial and fungal organisms have evolved elaborate sets of modular glycoside hydrolases and similar enzymes aimed at the degradation of polymeric…”
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Backbone Interactions Between Transcriptional Activator ExsA and Anti-Activator ExsD Facilitate Regulation of the Type III Secretion System in Pseudomonas aeruginosa by Shrestha, Manisha, Bernhards, Robert C., Fu, Yichen, Ryan, Kylie, Schubot, Florian D.

“…The type III secretion system (T3SS) is a pivotal virulence mechanism of many Gram-negative bacteria. During infection, the syringe-like T3SS injects cytotoxic…”
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Using a Concept Inventory to Reveal Student Thinking Associated with Common Misconceptions about Antibiotic Resistance by Stevens, Ann M, Smith, Ann C, Marbach-Ad, Gili, Balcom, Sarah A, Buchner, John, Daniel, Sandra L, DeStefano, Jeffrey J, El-Sayed, Najib M, Frauwirth, Kenneth, Lee, Vincent T, McIver, Kevin S, Melville, Stephen B, Mosser, David M, Popham, David L, Scharf, Birgit E, Schubot, Florian D, Seyler, Jr, Richard W, Shields, Patricia Ann, Song, Wenxia, Stein, Daniel C, Stewart, Richard C, Thompson, Katerina V, Yang, Zhaomin, Yarwood, Stephanie A

“…Misconceptions, also known as alternate conceptions, about key concepts often hinder the ability of students to learn new knowledge. Concept inventories (CIs)…”
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Structural Basis for the Substrate Specificity of the Feruloyl Esterase Domain of the Cellulosomal Xylanase Z from Clostridium thermocellum by Schubot, Florian D, Kataeva, Irina A, Blum, David L, Shah, Ashit K, Ljungdahl, Lars G, Rose, John P, Wang, Bi-Cheng

“…Feruloyl esterases function in the cleavage of ferulic acid's bonds to arabinoxylan and pectin where the ferulic acid moieties cross-link the layers of…”
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A Naturally Variable Residue in the S1 Subsite of M1 Family Aminopeptidases Modulates Catalytic Properties and Promotes Functional Specialization by Dalal, Seema, Ragheb, Daniel R.T., Schubot, Florian D., Klemba, Michael

“…M1 family metallo-aminopeptidases fulfill a wide range of critical and in some cases medically relevant roles in humans and human pathogens. The specificity of…”
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Self-Association Is Required for Occupation of Adjacent Binding Sites in Pseudomonas aeruginosa Type III Secretion System Promoters by Marsden, Anne E, Schubot, Florian D, Yahr, Timothy L

“…ExsA is a member of the AraC/XylS family of transcriptional regulators and is required for expression of the Pseudomonas aeruginosa type III secretion system…”
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On increasing protein-crystallization throughput for X-ray diffraction studies by Shah, Ashit K., Liu, Zhi-Jie, Stewart, Patrick D., Schubot, Florian D., Rose, John P., Newton, M. Gary, Wang, Bi-Cheng

“…Two recent developments, a novel screening/optimization strategy that considerably reduces the number of trials required to produce diffraction‐size crystals…”
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The catalytic domain of the germination-specific lytic transglycosylase SleB from Bacillus anthracis displays a unique active site topology by Jing, Xing, Robinson, Howard R., Heffron, Jared D., Popham, David L., Schubot, Florian D.

“…Bacillus anthracis produces metabolically inactive spores. Germination of these spores requires germination‐specific lytic enzymes (GSLEs) that degrade the…”
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Selection and characterization of Yersinia pestis YopN mutants that constitutively block Yop secretion by Ferracci, Franco, Schubot, Florian D., Waugh, David S., Plano, Gregory V.

“…Summary Secretion of Yop effector proteins by the Yersinia pestis plasmid pCD1‐encoded type III secretion system (T3SS) is regulated in response to specific…”
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Self‐trimerization of ExsD limits inhibition of the Pseudomonas aeruginosa transcriptional activator ExsA in vitro by Bernhards, Robert C., Marsden, Anne E., Esher, Shannon K., Yahr, Timothy L., Schubot, Florian D.

“…The opportunistic pathogen Pseudomonas aeruginosa ranks among the leading causes of nosocomial infection. The type III secretion system (T3SS) aids acute…”
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