Search Results - "Schubiger, P. A"

Synthesis and Properties of Boranocarbonate:  A Convenient in Situ CO Source for the Aqueous Preparation of [99mTc(OH2)3(CO)3] by Alberto, Roger, Ortner, Kirstin, Wheatley, Nigel, Schibli, Roger, Schubiger, August P

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Stable one-step technetium-99m labeling of His-tagged recombinant proteins with a novel Tc(I)-carbonyl complex by Plückthun, Andreas, Waibel, Robert, Alberto, Roger, Willuda, Jörg, Finnern, Ricarda, Schibli, Roger, Stichelberger, Albert, Egli, André, Abram, Ulrich, Mach, Jean-Pierre, Schubiger, P. August

“…We have developed a technetium labeling technology based on a new organometallic chemistry, which involves simple mixing of the novel reagent, a 99m…”
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High thermal stability is essential for tumor targeting of antibody fragments engineering of a humanized anti-epithelial glycoprotein-2 (epithelial cell adhesion molecule) single-chain Fv fragment by WILLUDA, J, HONEGGER, A, WAIBEL, R, SCHUBIGER, P. A, STAHEL, R, ZANGEMEISTER-WITTKE, U, PLÜCKTHUN, A

“…The epithelial glycoprotein-2 is abundantly expressed on many solid tumors and is a suitable target for antibody-based therapy. In the present study, an…”
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The Metamorphosis of Radionuclide Production and Development at Paul Scherrer Institute by Grundler, P V, Eichler, R, Talip, Z, Schubiger, P A, Schibli, R, van der Meulen, N P

“…Radionuclide production and development has a long history at the Paul Scherrer Institute (PSI) and dates back to the founding times of its forerunner…”
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Targeting Superficial Bladder Cancer by the Intravesical Administration of Copper-67–Labeled Anti-MUC1 Mucin Monoclonal Antibody C595 by HUGHES, O. D. M, BISHOP, M. C, PERKINS, A. C, WASTIE, M. L, DENTON, G, PRICE, M. R, FRIER, M, DENLEY, H, RUTHERFORD, R, SCHUBIGER, P. A

“…More effective intravesical agents are required to limit the recurrence and progression of superficial bladder cancer. This study assessed the ability of…”
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Versatile synthetic approach to new bifunctional chelating agents tailor made for labeling with the fac-[M(CO) 3] + core (M = Tc, 99mTc, Re): synthesis, in vitro, and in vivo behavior of the model complex [M(APPA)(CO) 3] (appa = [(5-amino-pentyl)-pyridin-2-yl-methyl-amino]-acetic acid) by Stichelberger, Albert, Waibel, Robert, Dumas, Cécile, Schubiger, P.A, Schibli, Roger

“…A general synthetic approach for potent tridentate, bifunctional chelating agent (BFCA) for the [M(CO) 3] + fragment (M = 99gTc, 99mTc, and Re) has been…”
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Relevance relations for the concept of reproducibility by Atmanspacher, H., Bezzola Lambert, L., Folkers, G., Schubiger, P. A.

“…The concept of reproducibility is widely considered a cornerstone of scientific methodology. However, recent problems with the reproducibility of empirical…”
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Influence of the denticity of ligand systems on the in vitro and in vivo behavior of (99m)Tc(I)-tricarbonyl complexes: a hint for the future functionalization of biomolecules by Schibli, R, La Bella, R, Alberto, R, Garcia-Garayoa, E, Ortner, K, Abram, U, Schubiger, P A

“…Functionalization of biologically relevant molecules for the labeling with the novel fac-[(99m)Tc(OH(2))(3)(CO)(3)](+) precursor has gained considerable…”
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Dicarbonyl-nitrosyl-complexes of rhenium (Re) and technetium (Tc), a potentially new class of compounds for the direct radiolabeling of biomolecules by Rattat, D, Schubiger, P A, Berke, H G, Schmalle, H, Alberto, R

“…Re- and Tc-complexes of the oxidation state (+I) offer a useful synthetic pool for the labeling of biomolecules due to their co-ordination properties and…”
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A comparison of targetting of neuroblastoma with mIBG and anti L1-CAM antibody mAb chCE7: therapeutic efficacy in a neuroblastoma xenograft model and imaging of neuroblastoma patients by Hoefnagel, C. A., Rutgers, M., Buitenhuis, C. K. M., Smets, L. A., Kraker, J. de, Meli, M., Carrel, F., Amstutz, H., Schubiger, P. A., Novak-Hofer, I.

“…Iodine-131 labelled anti L1-CAM antibody mAb chCE7 was compared with the effective neuroblastoma-seeking agent ^sup 131^I-labelled metaiodobenzylguanidine…”
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Anti‐neuroblastoma antibody chCE7 binds to an isoform of L1‐CAM present in renal carcinoma cells by Meli, Marina L., Carrel, François, Waibel, Robert, Amstutz, Hanspeter, Crompton, Nigel, Jaussi, Rolf, Moch, Holger, Schubiger, P. August, Novak‐Hofer, Ilse

“…Immunoprecipitation after cell surface labeling of human neuroblastoma cells showed that the anti‐neuroblastoma monoclonal antibody (mAb) chCE7 binds to a…”
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[ 76Br]bromodeoxyuridine, a potential tracer for the measurement of cell proliferation by positron emission tomography, in vitro and in vivo studies in mice by Ryser, J.-E., Bläuenstein, P., Rémy, N., Weinreich, R., Hasler, P.H., Novak-Hofer, I., Schubiger, P.A.

“…5-Bromo-2′-deoxyuridine (BrUdR) labeled with 77Br and 76Br was compared with 5-iodo-2′-deoxyuridine (IUdR) labeled with 125I or 131I, first in vitro then in in…”
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Preclinical evaluation of copper-67 labelled anti-MUC1 mucin antibody C595 for therapeutic use in bladder cancer by Hughes, O D, Bishop, M C, Perkins, A C, Frier, M, Price, M R, Denton, G, Smith, A, Rutherford, R, Schubiger, P A

“…Transitional cell carcinoma of the bladder is the fifth commonest cause of death from cancer in men in the United Kingdom. Most patients present early with…”
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A 99mTc(I)-Postlabeled High Affinity Bombesin Analogue as a Potential Tumor Imaging Agent by La Bella, Garcia-Garayoa, E, Bähler, Bläuenstein, P, Schibli, R, Conrath, P, Tourwé, D, Schubiger, P. A

“…The overexpression of neuropeptide receptors observed in many cancers provides an attractive target for tumor imaging and therapy. Bombesin is a peptide…”
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A Novel Organometallic Aqua Complex of Technetium for the Labeling of Biomolecules:  Synthesis of [99mTc(OH2)3(CO)3]+ from [99mTcO4]- in Aqueous Solution and Its Reaction with a Bifunctional Ligand by Alberto, Roger, Schibli, Roger, Egli, André, Schubiger, August P., Abram, Ulrich, Kaden, Thomas A.

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Basic aqueous chemistry of [M(OH 2) 3(CO) 3] + (M=Re, Tc) directed towards radiopharmaceutical application by Alberto, Roger, Schibli, Roger, Waibel, Robert, Abram, Ulrich, Schubiger, August P.

“…A review on the synthesis and properties of the organometallic aqua-ion [M(OH 2) 3(CO) 3] + (M=Re, 99Tc, 99mTc), as relevant for radiopharmaceutical…”
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Comparison of N-[ 11C]methyl-norchloroepibatidine and N-[ 11C]methyl-2-(2-pyridyl)-7-azabicyclo[2.2.1]heptane with N-[ 11C]methyl-epibatidine in small animal PET studies by Spang, J.E., Patt, J.T., Westera, G., Schubiger, P.A.

“…Structural variations of the nicotinic acetylcholine receptor radioligand N-[ 11C]methyl-epibatidine were made to form 11C-labeled…”
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New [99mTc]bombesin analogues with improved biodistribution for targeting gastrin releasing-peptide receptor-positive tumors by García Garayoa, E, Schweinsberg, C, Maes, V, Rüegg, D, Blanc, A, Bläuenstein, P, Tourwé, D A, Beck-Sickinger, A G, Schubiger, P A

“…Bombesin (BBS) receptors are potential targets for diagnosis and therapy of breast and prostate tumors. To overcome the rapid degradation of natural BBS some…”
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Ligand Selectivity for the Acetylcholine Binding Site of the Rat α4β2 and α3β4 Nicotinic Subtypes Investigated by Molecular Docking by Bisson, William H, Scapozza, Leonardo, Westera, Gerrit, Mu, Linjing, Schubiger, P. A

“…The homology models of the extracellular domains of the neuronal α4β2 (pdb code:  1ole) and ganglionic α3β4 (pdb code:  1olf) rat nicotinic acetylcholine…”
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Production and separation of ''non-standard'' PET nuclides at a large cyclotron facility: the experiences at the Paul Scherrer Institute in Switzerland by Hohn, A, Zimmermann, K, Schaub, E, Hirzel, W, Schubiger, P A, Schibli, R

“…Radioimmuno-positron emission tomography (PET) combined with radioimmunotherapy is attractive to assess tumor targeting and quantitate the radiation dose to…”
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