Search Results - "Schubert, Jeffrey"

Derivatization of Amino Acids and Peptides via Photoredox-Mediated Conjugate Addition by Zhang, Olivia, Schubert, Jeffrey W

“…Unnatural amino acids are key building blocks in therapeutically relevant peptides. Thus, the development of novel methods to increase the structural diversity…”
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Application of Next Generation Sequencing in Laboratory Medicine by Zhong, Yiming, Xu, Feng, Wu, Jinhua, Schubert, Jeffrey, Li, Marilyn M

“…The rapid development of next-generation sequencing (NGS) technology, including advances in sequencing chemistry, sequencing technologies, bioinformatics, and…”
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Photoredox Catalysis for Silyl‐Mediated C–H Alkylation of Heterocycles with Non‐Activated Alkyl Bromides by Perkins, James J., Schubert, Jeffrey W., Streckfuss, Eric C., Balsells, Jaume, ElMarrouni, Abdellatif

“…The development of a Minisci reaction of electron‐deficient heteroarenes with non‐activated alkyl bromides under visible‐light photoredox catalysis is…”
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The genetic architecture of pediatric cardiomyopathy by Ware, Stephanie M., Bhatnagar, Surbhi, Dexheimer, Phillip J., Wilkinson, James D., Sridhar, Arthi, Fan, Xiao, Shen, Yufeng, Tariq, Muhammad, Schubert, Jeffrey A., Colan, Steven D., Shi, Ling, Canter, Charles E., Hsu, Daphne T., Bansal, Neha, Webber, Steven A., Everitt, Melanie D., Kantor, Paul F., Rossano, Joseph W., Pahl, Elfriede, Rusconi, Paolo, Lee, Teresa M., Towbin, Jeffrey A., Lal, Ashwin K., Chung, Wendy K., Miller, Erin M., Aronow, Bruce, Martin, Lisa J., Lipshultz, Steven E.

“…To understand the genetic contribution to primary pediatric cardiomyopathy, we performed exome sequencing in a large cohort of 528 children with…”
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Discovery of [11C]MK-6884: A Positron Emission Tomography (PET) Imaging Agent for the Study of M4Muscarinic Receptor Positive Allosteric Modulators (PAMs) in Neurodegenerative Diseases by Tong, Ling, Li, Wenping, Lo, Michael Man-Chu, Gao, Xiaolei, Wai, Jenny Miu-Chen, Rudd, Michael, Tellers, David, Joshi, Aniket, Zeng, Zhizhen, Miller, Patricia, Salinas, Cristian, Riffel, Kerry, Haley, Hyking, Purcell, Mona, Holahan, Marie, Gantert, Liza, Schubert, Jeffrey W, Jones, Kristen, Mulhearn, James, Egbertson, Melissa, Meng, Zhaoyang, Hanney, Barbara, Gomez, Robert, Harrison, Scott T, McQuade, Paul, Bueters, Tjerk, Uslaner, Jason, Morrow, John, Thomson, Fiona, Kong, Jongrock, Liao, Jing, Selyutin, Oleg, Bao, Jianming, Hastings, Nicholas B, Agrawal, Sony, Magliaro, Brian C, Monsma, Frederick J, Smith, Michelle D, Risso, Stefania, Hesk, David, Hostetler, Eric, Mazzola, Robert

“…The measurement of receptor occupancy (RO) using positron emission tomography (PET) has been instrumental in guiding discovery and development of CNS directed…”
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2-Aminopyridines as Potent and Selective Na v 1.8 Inhibitors Exhibiting Efficacy in a Nonhuman Primate Pain Model by Breslin, Michael J, Schubert, Jeffrey W, Wang, Deping, Huang, Chienjung, Clements, Michelle K, Li, Yuxing, Zhou, Xiaoping, Vardigan, Joshua D, Kraus, Richard L, Santarelli, Vincent P, Uslaner, Jason M, Coleman, Paul J, Stachel, Shawn J

“…Herein we describe the discovery of a 2-aminopyridine scaffold as a potent and isoform selective inhibitor of the Na 1.8 sodium channel. Parallel library…”
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2‑Aminopyridines as Potent and Selective Nav1.8 Inhibitors Exhibiting Efficacy in a Nonhuman Primate Pain Model by Breslin, Michael J., Schubert, Jeffrey W., Wang, Deping, Huang, Chienjung, Clements, Michelle K., Li, Yuxing, Zhou, Xiaoping, Vardigan, Joshua D., Kraus, Richard L., Santarelli, Vincent P., Uslaner, Jason M., Coleman, Paul J., Stachel, Shawn J.

“…Herein we describe the discovery of a 2-aminopyridine scaffold as a potent and isoform selective inhibitor of the Nav1.8 sodium channel. Parallel library…”
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Genomic profiling of pediatric hematologic malignancies and diagnosis of cancer predisposition syndromes: tumor-only versus paired tumor-normal sequencing by Newman, Haley, Clark, Mary Egan, Wong, Derek, Wu, Jinhua, Brodeur, Garrett M, Hunger, Stephen P, Tasian, Sarah K, Olson, Timothy, Warren, Julia T, Teachey, David T, Bona, Kira, Schubert, Jeffrey, Golenberg, Netta, Patel, Maha, Denenberg, Elizabeth H, Fanning, Elizabeth A, Chen, Jiani, Luke, Tamara, Charles, Sarah, Gallo, Daniel, Cao, Kajia, Fu, Weixuan, Fan, Zhiqian, Surrey, Lea F, Wertheim, Gerald, Luo, Minjie, MacFarland, Suzanne P, Li, Marilyn M, Zhong, Yiming

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Clinically relevant variants identified in thoracic aortic aneurysm patients by research exome sequencing by Schubert, Jeffrey A., Landis, Benjamin J., Shikany, Amy R., Hinton, Robert B., Ware, Stephanie M.

“…Thoracic aortic aneurysm (TAA) is a genetically heterogeneous disease involving subclinical and progressive dilation of the thoracic aorta, which can lead to…”
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Discovery, Optimization, and Biological Characterization of 2,3,6-Trisubstituted Pyridine-Containing M 4 Positive Allosteric Modulators by Schubert, Jeffrey W, Harrison, Scott T, Mulhearn, James, Gomez, Robert, Tynebor, Robert, Jones, Kristen, Bunda, Jaime, Hanney, Barbara, Wai, Jenny Miu-Chen, Cox, Chris, McCauley, John A, Sanders, John M, Magliaro, Brian, O'Brien, Julie, Pajkovic, Natasa, Huszar Agrapides, Sarah L, Taylor, Anne, Gotter, Anthony, Smith, Sean M, Uslaner, Jason, Browne, Susan, Risso, Stefania, Egbertson, Melissa

“…Herein we describe the discovery and optimization of a new series of 2,3-disubstituted and 2,3,6-trisubstituted muscarinic acetylcholine receptor 4 (M )…”
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Limited-View X-Ray Tomography Combining Attenuation and Compton Scatter Data: Approach and Experimental Results by Desmal, Abdulla, Schubert, Jeffrey R., Denker, Jeffrey, Kisner, Sherman J., Rezaee, Hamideh, Couture, Aaron, Miller, Eric L., Tracey, Brian H.

“…X-ray inspection systems are critical in medical, non-destructive testing, and security applications, with systems typically measuring attenuation along…”
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Novel ATXN1/ATXN1L::NUTM2A fusions identified in aggressive infant sarcomas with gene expression and methylation patterns similar to CIC-rearranged sarcoma by Xu, Feng, Viaene, Angela N., Ruiz, Jenny, Schubert, Jeffrey, Wu, Jinhua, Chen, Jiani, Cao, Kajia, Fu, Weixuan, Bagatell, Rochelle, Fan, Zhiqian, Long, Ariel, Pagliaroli, Luca, Zhong, Yiming, Luo, Minjie, Kreiger, Portia A., Surrey, Lea F., Wertheim, Gerald B., Cole, Kristina A., Li, Marilyn M., Santi, Mariarita, Storm, Phillip B.

“…CIC -rearranged sarcomas are newly defined undifferentiated soft tissue tumors with CIC- associated fusions, and dismal prognosis. CIC fusions activate PEA3…”
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Exome Sequencing Identifies Candidate Genetic Modifiers of Syndromic and Familial Thoracic Aortic Aneurysm Severity by Landis, Benjamin J., Schubert, Jeffrey A., Lai, Dongbing, Jegga, Anil G., Shikany, Amy R., Foroud, Tatiana, Ware, Stephanie M., Hinton, Robert B.

“…Thoracic aortic aneurysm (TAA) is a genetic disease predisposing to aortic dissection. It is important to identify the genetic modifiers controlling penetrance…”
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Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT) by Harrison, Scott T, Poslusney, Michael S, Mulhearn, James J, Zhao, Zhijian, Kett, Nathan R, Schubert, Jeffrey W, Melamed, Jeffrey Y, Allison, Timothy J, Patel, Sangita B, Sanders, John M, Sharma, Sujata, Smith, Robert F, Hall, Dawn L, Robinson, Ronald G, Sachs, Nancy A, Hutson, Pete H, Wolkenberg, Scott E, Barrow, James C

“…3-Hydroxy-4-pyridinones and 5-hydroxy-4-pyrimidinones were identified as inhibitors of catechol-O-methyltransferase (COMT) in a high-throughput screen. These…”
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Discovery, Optimization, and Biological Characterization of 2,3,6‐Trisubstituted Pyridine‐Containing M4 Positive Allosteric Modulators by Schubert, Jeffrey W., Harrison, Scott T., Mulhearn, James, Gomez, Robert, Tynebor, Robert, Jones, Kristen, Bunda, Jaime, Hanney, Barbara, Wai, Jenny Miu‐Chen, Cox, Chris, McCauley, John A., Sanders, John M., Magliaro, Brian, O'Brien, Julie, Pajkovic, Natasa, Huszar Agrapides, Sarah L., Taylor, Anne, Gotter, Anthony, Smith, Sean M., Uslaner, Jason, Browne, Susan, Risso, Stefania, Egbertson, Melissa

“…Herein we describe the discovery and optimization of a new series of 2,3‐disubstituted and 2,3,6‐trisubstituted muscarinic acetylcholine receptor 4 (M4)…”
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Synthesis and optimization of N-heterocyclic pyridinones as catechol-O-methyltransferase (COMT) inhibitors by Zhao, Zhijian, Harrison, Scott T., Schubert, Jeffrey W., Sanders, John M., Polsky-Fisher, Stacey, Zhang, Nanyan Rena, McLoughlin, Debra, Gibson, Christopher R., Robinson, Ronald G., Sachs, Nancy A., Kandebo, Monika, Yao, Lihang, Smith, Sean M., Hutson, Pete H., Wolkenberg, Scott E., Barrow, James C.

“…[Display omitted] A series of N-heterocyclic pyridinone catechol-O-methyltransferase (COMT) inhibitors were synthesized. Physicochemical properties, including…”
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Evidence for β-Chlorocarbenium and β-Bromocarbenium Ions by Ohta, Brian K, Hough, Ruth E, Schubert, Jeffrey W

“…Isotopic perturbation of degenerate equilibrium is used to determine whether tetramethylethylenechloronium and tetramethylethylenebromonium ions are closed…”
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Genetic Causes of Cardiomyopathy in Children: First Results From the Pediatric Cardiomyopathy Genes Study by Ware, Stephanie M, Wilkinson, James D, Tariq, Muhammad, Schubert, Jeffrey A, Sridhar, Arthi, Colan, Steven D, Shi, Ling, Canter, Charles E, Hsu, Daphne T, Webber, Steven A, Dodd, Debra A, Everitt, Melanie D, Kantor, Paul F, Addonizio, Linda J, Jefferies, John L, Rossano, Joseph W, Pahl, Elfriede, Rusconi, Paolo, Chung, Wendy K, Lee, Teresa, Towbin, Jeffrey A, Lal, Ashwin K, Bhatnagar, Surbhi, Aronow, Bruce, Dexheimer, Phillip J, Martin, Lisa J, Miller, Erin M, Sleeper, Lynn A, Razoky, Hiedy, Czachor, Jason, Lipshultz, Steven E

“…Background Pediatric cardiomyopathy is a genetically heterogeneous disease with substantial morbidity and mortality. Current guidelines recommend genetic…”
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Characterization of Non-Nitrocatechol Pan and Isoform Specific Catechol-O-methyltransferase Inhibitors and Substrates by Robinson, Ronald G, Smith, Sean M, Wolkenberg, Scott E, Kandebo, Monika, Yao, Lihang, Gibson, Christopher R, Harrison, Scott T, Polsky-Fisher, Stacey, Barrow, James C, Manley, Peter J, Mulhearn, James J, Nanda, Kausik K, Schubert, Jeffrey W, Trotter, B. Wesley, Zhao, Zhijian, Sanders, John M, Smith, Robert F, McLoughlin, Debra, Sharma, Sujata, Hall, Dawn L, Walker, Tiffany L, Kershner, Jennifer L, Bhandari, Neetesh, Hutson, Pete H, Sachs, Nancy A

“…Reduced dopamine neurotransmission in the prefrontal cortex has been implicated as causal for the negative symptoms and cognitive deficit associated with…”
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Theoretical Investigation of Lone Pair Inversions, Ring Openings, and Hydride Shifts in O-Methylated Epoxides by Schubert, Jeffrey W, Dudley, Timothy J, Ohta, Brian K

“…Mechanisms associated with the isomerization of the O-methylethylene oxonium ion and its tetramethyl-substituted analogue have been explored using correlated…”
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